The international top issue sounds again, and the short life of men is more likely to add scientific evidence!

From ancient times to the present. Men's life is generally shorter than women. According to data from the World Health Organization, the average life expectancy of women is 5 to 7 years older than men. Why is men's life shorter? There are divergent opinions of scientists, and some think that the length of men's telomeres is generally shorter than women, and some think that it is caused by the differences between the hormones secreted by men and women. Living habits.

It sounds very reasonable, but this is not all answers. Recently, the top journal "Science" published a study, which found that the reason for the short life of men was mainly caused by special Y chromosome loss.

The loss of Y chromosome

Scientists conducted in -depth research on Y chromosomes in the last century and found that Y chromosome was a genetic "garbage dump". The only function was sperm that determined the next generation of gender. If the sperm carrys Y chromosomes, then the boy is born. If the sperm carrys the X chromosome, then the girl is born.

As men grow older, some cells such as blood cells will gradually lose Y chromosomes. This change is called MLOY (Loss of Y). Among them, the probability of smoking men will have a higher probability of MLOY. In general, the average proportion of MLOY among 60 -year -old men is 20%, while among 70 -year -old men, this proportion has risen rapidly to 40%, and 90 -year -old men have risen to 57%.

The harm after losing Y chromosome

Although Y chromosome is a genetic "garbage dump", the loss of Y chromosomes in fact can greatly pose a great threat to men's health. Previous research shows that men who have lost Y chromosomes are more likely to die when they are young, and the risk of dementia in the elderly increases to three times the risk of dementia.

In order to explore the harm brought by more MLOY, the researchers used gene editing technicians to delete the Y chromosomes of mice and simulate the phenomenon of MLOY. It was found that it was not too abnormal when they were young. Severe heart fibrosis. Compared with normal mice, mice who have lost Y chromosomes have a shorter survival period, generally manifested as heart damage, abnormal inflammation level, and fibrosis of the whole body.

Researchers also verified in humans. They found that men who could detect the loss of Y chromosome, which died of heart failure and other cardiovascular diseases by 30%in the 11 years of subsequent investigation.

All of the above evidence shows that Y chromosomes are not as "waste" as we think. So far, scientists have found six genes that affect health in Y chromosomes. These genes are related to the normal operation of the immune system. The dyeing experience directly affects our health.

Do you lose your life when you lose Y dyeing?

The loss of Y chromosomes will not only affect health, but the researchers also find that it can change the expected life. Researchers analyzed the expected life record of nearly 1,5700 cardiovascular diseases, and found that the loss of Y chromosome can explain more than 75% of the life span of men over 60 years old and women. Four years of life span of five years. "

The person in charge of the study said that the discovery of the study may also bring new revelation to aging and related diseases, telling us that the loss of Y chromosome may be a major "culprit" for male aging.

—— Timepie- ——

- END -