"I don't want to eat it anymore!"

Text ｜ "China Science News" reporter Han Yangmei

I want to lose weight without hazards and exercise. This is the dream of weight loss.

Recently, scientific researchers have developed a highly safe and free injection of new drugs. Experiments have proven to be effective in weight loss.

On July 8th, the latest achievements of Zhao Fangqing, a researcher at the Beijing Institute of Life Sciences of the Chinese Academy of Sciences on July 8th.

They used a variety of dietary obesity animals such as mice, rats, and macaques to confirm that its independently developed "intestinal and brain axis" can have a significant weight loss effect.

Key weight loss molecule "small peptide D3"

Although the launching weight loss pills can make people lose weight in a short period of time, their multiple gastrointestinal side effects and injection of injection are often unbearable.

More and more studies have shown that small peptides can effectively affect the metabolism of the body and regulate the structure of the intestinal flora, and small peptide drugs have been widely used to prevent and treat various diseases due to high safety and small side effects.

Small peptide D3 is a key weight loss element captured by scientific researchers.

It acts on the intestine, microorganisms and brains, which can control the amount of diet, but also enhance the intestinal defense function.

Doctoral student and first author Li Zhanzhan told the Journal of China. D3 directly acts on the intestine, which can stimulate intestinal epithelial cells to produce more anorexia (urinelin, UGN), while increasing the insulin and leptin of animals Sensitivity, these two hormones play an important role in the process of inhibiting the absorption of animals.

D3 can regulate the intestinal flora, which can also improve enterococcal disorders caused by high -fat diet and increase the abundance of beneficial bacteria AKK.

"The mechanism of changes in the flora structure is complicated, and small energy changes can be reshaped its structure." Li Zhanzhan said that different bacteria dependence on energy intake is different. For example, some bacteria of thick walls can help the host absorb energy energy. So when they eat less, they also decrease. In order to maintain a "balance" state, other bacteria breed quickly, making the intestinal flora ecology gradually change.

D3 also acts on the brain. It stimulates the intestinal tract to produce anorexia, thereby enhancing the POMC neuron activity with food suppression effects in the hypothalamus, and transmits signals to the brain: I don't want to eat it anymore!

D3 is a "weight loss" mechanism that uses the intestine as the target and can activate the intestinal flora and the brain. Researchers are called the "intestinal brain axis".

You can lose weight as soon as 6 weeks

The researchers screened a small peptide that can improve metabolic function from the end product of the human body fluid defense of the intestinal liquid enzyme, and then obtained a small peptide D3 with high -cell affinity based on intelligent design.

A variety of dietary obesity animals such as mice, rats and macaques are experimental models, and these animals are given high -fat diet. Researchers take D3 every day, or take up their stomachs, record their weight, feed volume every day, and collect feces to monitor their flora changes.

It was found that in 6 weeks, the weight of the macaques dropped by about 7.71%, and the weight of mice and rats also decreased by 12.06%and 8.89%in 8 weeks and 10 weeks, respectively.

Studies have also found that D3 has the same weight loss effect on obesity mice, and can reduce high blood sugar caused by high -fat diet and improve insulin tolerance.

Researchers have further discovered that the bacteria with strong correlation with obesity have also changed, which also shows that D3 has the ability to resist enterococcal disorders caused by obesity, that is, reducing harmful bacteria and improving the abundance of beneficial bacteria.

Zhang Bing, a doctoral student and the first author of the paper, said that it found that fungus such as Oscillospira and Desulfovibrio in the animal intestine was significantly reduced.

Among them, the abundance of Desulfovibrio is positively related to obesity. They can produce hydrogen sulfide, destroy the intestinal epithelium mucosa, and induce chronic inflammation.

According to studies, after the sterile mouse was given Desulfovibrio, the body fat rate of mice increased, and the CD36 gene expression that promoted lipid absorption in the body increased.

"The quantitative results show that Akkermansia has increased by about 100 times, which is a star of star bacteria. Existing research shows that it can reverse metabolic disorders caused by high -fat diet, including increased fat, metabolic toxins, fat tissue inflammation and insulin resistance Wait. After the D3 processing, it can significantly increase the abundance of Aksmann, up to 300 times. "Zhang Bing said.

No side effects are found yet

For the first time, the study developed a small molecular peptide with high safety and oral weight loss, and systematically explained the dual action mechanism of the D3's action targeted parts and its separation of the owner and enterococcal. Candidates for the treatment of dietary obesity.

Communication author Zhao Fangqing said that the advantage of D3 is that it can be used orally, which greatly enhances the patient's compliance.

In addition, the molecular weight of D3 is small and the synthetic cost is lower.

"Research provides new ideas for the internal and external screening methods that expand oral small molecular drugs, and at the same time provide a new angle for developing anti -obesity drugs around the‘ intestinal brain axis ”."

Users are most concerned about the side effects of weight loss pills. Researchers said that in the current intervention of the three animal models, none of them observed gastrointestinal reactions such as vomiting common vomiting in other diet pills.

"We have done the conditional smell of the condition of mice. The results show that there is no obvious taste disgusting reaction after the D3 of mice is consumed in the short term." Li Zhanzhan said that the side effects are generally related to the use cycle.They plan next.The research team will continue to conduct research on medicine nature, pharmacological toxicology and pharmacokinetics, and at the same time cooperate with hospitals to conduct forward -looking clinical studies to further observe its results.

Related thesis information:

http://doi.org/10.1136/Gutjnl-2022-328035

"China Science News" (2022-07-13 Comprehensive)

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Edit | Zhao Lu

Capture | Guo Gang

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