The drug gene is negative, why is the disease?Will it cause cholera?

The Health and Health Bureau of Wuchang District, Wuhan City, Hubei reported on the 11th that a student of Wuhan University was diagnosed with cholera. The professional appraisal of the disease and control department pointed out that the serotism condensation test of this case is O139 positive, diagnosed with cholera, and toxic gene negative.

Some netizens leave a message: What does the toxic power gene mean?

Literally, the illness and control department conducts genetic testing of strains that cause cholera. The result is "negative", which means that this strain does not have toxic power genes. Why can it still cause diarrhea in patients? What does the serum science condensation test mean O139 positive? A reporter from the Science and Technology Daily interviewed Guo Wei, deputy director of the Infectious Department of Tongji Hospital of Huazhong University of Science and Technology, answered questions.

What is the toxic power gene?

The naming of genes is basically related to its protein. The "toxic force" in the toxic gene reported by the health department refers to the cholera bowl of cholera. Toxic power gene is the gene to encoding cholera toxins.

"Choisylhhexin is the most important pathogenic factors in cholera, and it is currently the most toxin toxins that cause diarrhea toxins." Guo Wei told the science and technology daily reporter that if the infected strains have this toxic power gene Bacteria will secrete cholera bowl to attack the patient's intestinal mucosal cells, and the cells will continuously secrete liquid, and gastrointestinal tract is discharged from a large amount of liquid like "opening and putting water". Dehydration.

It is conceivable that the clinical symptoms of patients with poisonous genes will be very serious. "A large number of cells dehydrated and necrotic can also lead to some serious complications, including renal failure, hyperkalemia, arrhythmia, etc. It will be life -threatening if it is not treated in time." Guo Wei said.

Is negative "non -toxic"?

So, does the toxic force of cholera virus do not exist, is it non -toxic? it's not true.

"Vibriolasmius also secretes other harmful substances to the human body, such as internal toxins, hemolytin, hemorchin, etc." Guo Wei said, especially the effect of internal toxins in the disease Cases of sepsis and meningitis.

"However, most patients can recover without using antibiotics without using antibiotics." Guo Wei emphasized that although it is a bacterial infectious disease, the most important thing for treating cholera is the treatment. fatal. Antibiotic treatment can only shorten the treatment and reduce the number of diarrhea, which is auxiliary treatment method for liquid therapy. Therefore, antibiotics are not advocated.

The "secret words" of the toxic power gene

So, why do the disease control department pay special attention to the "toxic power gene" and emphasize its negativeness? It turned out that there were professional "secret words" hidden behind the toxic power gene.

"The biggest significance of the toxic power gene is not to answer the symptoms, but the problem of bacterial communication." Guo Wei told the reporter of the Science and Technology Daily that the negative of the toxic power gene means that it is difficult to cause great popularity.

The toxic power gene has a popular significance of epidemiological diseases, and negative means that the propagation power is very low and the possibility of popularity is small. If positive is detected, it means that it may lead to great popularity, and prevention and control measures need to be stricter.

Why is the toxic power gene and communication power?

A summary article published by the American Academy of Sciences in 2003 shows that the choleramus is based on its O antigen group. At present, at least 206 choleramia serum groups are known (can be imagined as a different Kye family).

Before O139 appeared, O1 was the only "family" that caused too much popularity. Moreover, the positive of popularity and toxic power genes has always appeared at the same time.

In 1992, more than 100,000 patients in Bangladesh had a cholera, which was separated from 124 strains but not O1.

"Hoo Lius bacteria have whip and hair, just like a small engine. In the dark field of view, they will run constantly. The exercise power is particularly strong, but as long as it is added to the serum of the serum group, the 'motor' is locked. "Guo Wei said that the anti -serum corresponding to different serum groups can be used to initially distinguish the" family "of cholera.

It was found that the Bangladesh triggered strains could still run after joining the corresponding condensation serum. A new strain that causes popularity and O1 is found. The aforementioned papers evaluate: Non -O1 serum groups will not cause the concept of large -scale diarrhea explosion.

Despite the emergence of new O139, it also follows the law that has a toxic power gene.

"Logically, it is also well understood. The positive bacteria of the toxic power gene can secrete the cholera bowl, which can cause severe diarrhea; more excrement excretion, the more likely it is to pollute the environment and water source, which can lead to more infection in the future." Guo Wei said, said, This is very similar to the "sowing" ability of plants. It has the ability to spread, leading to great popularity, and poor spreading ability leads to only individual infections. Therefore, none of the poisonous genes are one of the keys to determining whether cholera can be popular.

Source: Science and Technology Daily

- END -