"Ice Brick Challenge" has become popular around the world 8 years later, AI empowers to accurately lock 18 new targets

At present, there are more than 700,000 patients with gradients worldwide worldwide. Time is the world's first Suberg (semi-robot) Peter 2.0 (Peter Scott-Morgan) reported on June 26. Related reading: "The world's first semi -robot died, and the road of Siber did not lead to longevity/eternal life?"). Celestial Physics Tydam Hawking, as well as the people's hero of the new crown epidemic in Wuhan, Dean Zhang Dingyu of Jin Yintan Hospital (the prototype of Zhang Hanyu played by Zhang Hanyu in the movie "Chinese Doctor") was also tortured by gradual frost.

After suffering from this illness, people will lose their ability to move their autonomous muscles. They cannot walk, speak, eat, and eventually cannot breathe. This abnormal "brutal" neurodegenerative disease worsening is usually very fast. From the beginning of the symptoms, the average life expectancy of patients is only 2 to 5 years. But unfortunately, the existing approved therapeutic drugs cannot prevent or reverse the loss.

INSILICO Medicine is an artificial intelligence -driven end -to -end drug research and development company in the clinical stage. The company's research team conducted a large number of data set searches with its proprietary AI driver target recognition engine Pandaomics ™, and finally determined the genes related to the muscle atrophy side sclerosis (ALS, later referred to as gradual freezing). These genes of these genes Can be the target of new therapy. The study is the largest and most comprehensive gradual freezing research project in history. The research results were published on June 28 on Frontiers in Aging Neuroscience.

PANDAOMICS ™ is an exclusive AI -drive target recognition engine of Insilico. The research team uses this engine to analyze the DNA micro -array and RNA sequencing data set from the central nervous system (CNS) of the public dataset, as well as the induction of the ANSWER ALS project. Multifunctional stem cells derived from the transcription group and protein group data.

According to analysis, the research team screened 28 new potential therapeutic targets from the CNS and DIMN samples, of which 17 were high -settings targets. But can the target of AI screen pass through the test test? Subsequently, the research team used the fruit fly model that simulated the most common genetic reasons of felmeal disease. By regulating the level of expression in fruit flies and observing the changes in fruit flies by adjusting the 28 "candidate targets" to verify its correlation. The results showed that 18 target passed the verification, indicating that it had significant functional correlation with gradient disease.

Figure: A few targets (marked as green) include neuronal cell death, oxidation stress, neuritis and protein stabilized dysfunctional dysfunction

It is worth noting that there are 8 genes that have never been reported before these targets, including KCNB2, KCNS3, ADRA2B, NR3C1, P2RY14, PPP3CB, PTPRC, and RARA. The neurotic degeneration of the flies eye allows it to restore the normal phenotype.

Dr. Alex Zhavoronkov, the founder and CEO of Insilico Medicine, said: "The results of this cooperation study fully show that combining human professional knowledge with artificial intelligence tools will collide out of wonderful sparks -in the face of the previously unprecedented diseases, they can be able to exhibit diseases. Accurately lock new therapeutic targets. "" This is just the beginning. "

Professor of Tsinghua University Dr. Lu Bai also participated in the study. In an interview, he said: "From the founding of AI -based drivers based on massive data sets, it was found to be carried out through multiple model systems (fruit flies, mice, and human IPS cells). Biology verification, and the rapid clinical test conducted by the test (IIT) initiated by researchers, which represents a new trend, which may significantly reduce costs and time. More importantly Drugs for neurodegenerative diseases. "

We look forward to the development of more new ways to be applied to the development of gestallations of drugs in the future, helping us better understand this rare and fatal neurotome disease; it also looks forward to artificial intelligence and big data that can be more comprehensive and accurate. Powerful medical research adds to the development of all human health.

The study was led by Dr. Frank Pun, the head of the Insilico Greater Bay Area team, from researchers from Meo Clinic, Zurich University, Tsinghua University, 4B Technologies, Johns Hopkins Medical College, Harvard Medical College and Barc. This study made contributions.

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