New crown vaccine vs neutralize antibodies, how to choose the new crown?Expert: should be vaccinated priority

On July 9, the Boao Super Hospital and Ruijin Hainan Hospital ushered in the first vaccinator of the new crown and antibody drug Evusheld. As the "only neutral antibody drug that can be used for new crowns before the exposure of the new crown", the price of tens of thousands of yuan and the difference between the vaccine have aroused widespread public discussion.

On July 10, Chang Rongshan, an expert in virus, accepted a telephone interview with the reporter of the Daily Economic News. He said that those who can take vaccines should be given priority to vaccination. EVUSHELD is mainly suitable for people with low immunity or people with risks exposed risks in the short term.

In addition, Chang Rongshan also called on the prerequisites where the aforementioned hospital is located in Hainan Boao Le City International Medical Tourism Pioneer Zone may consider using the MRNA vaccine as the next franchise.

On the afternoon of the 10th, Jin Dongyan, a professor at the School of Biomedicine of the University of Hong Kong and a virus expert, also told reporters in the telephone interview that it is very important to actively promote the launch of the MRNA vaccine.

The possibility of the infection of the new crown and antibody 染 is 0, and the three -pin new crown vaccine should be given priority

The title of "New Crown Virus Prevention" makes it easy for people to link EVUSHELD to the new crown vaccine and confuse the differences between the two. In fact, the two have essential differences.

The new crown vaccine is a deck of virus or virus. After injection, the body will have immune memories, and at the same time, antibodies can produce active immunity. Neutral antibody itself is an antibody and can directly enter the human body, which is passive immunity.

Jin Dongyan made a metaphor of an image: For non -immune -destructives, after inoculation of new crown vaccines, antibodies can naturally form in the body, which is equivalent to how the church body fights with the new crown virus; It's gone.

Therefore, from the perspective of antibodies, the new crown vaccine can help the human body form a sufficient number of antibodies, but it takes a longer time, usually more than two weeks; Blood concentration can resist the invasion of the new coronal virus within a certain period of time, but with the passage of time, the number of antibodies will decline, and the body is in a state of no protection.

From the perspective of the number of antibodies, after the human immune system learns how to "fight", the antibodies produced by it are much higher than the dose of neutralized antibody drugs, which is "the difference between thousands of troops and soldiers and soldiers."

On July 9, the reporter of "Daily Economic News" called the Boao Super Hospital as a consultant to publicly call. The staff who answered the answer said that many of the current appointment for the medication were abroad.

In this regard, Chang Rongshan said that this is also because for people who plan to go to high -infected risks in the short term, the effect of the new crown neutralized antibody drugs is "immediate". Unlike the inoculation of the new crown vaccine, it is necessary to wait for dozens of dozens God can produce neutralized antibodies higher than the protection threshold.

However, Chang Rongshan reminded that the effect of the new crown and antibody drugs is closely related to the dose. The vaccinator needs to ensure that its new crown exposure period is shorter than the period of drug failure.

In addition, after vaccination with a new crown vaccine or infusion of the new crown neutralized and antibodies, the recipients must abide by the local government's prevention and control guidance, comply with the prevention measures such as wearing masks in public places and maintaining social distances.

"Suppose you have a vaccine or EVUSHELD, do not wear a mask, encounter a person with a large amount of detoxification, and stay with him for a long time, and it will definitely be infected." Chang Rongshan said.

Jin Dongyan said that the new crown antibody drugs cannot replace the vaccine. For non -immune -defectives, they should take priority to vaccinate three -pin new crown vaccine; for people with immune function or low immunity, active immunization (injection of the new crown vaccine) is the best way to be the best way. , Rather than simply passive immunity (injection new crown neutralized antibodies).

So, which groups of people really need new crowns and antibody drugs?

Jin Dongyan believes that people who cannot inoculate the new crown vaccine, immune defects, and short -term exposed people who are capable and willing to buy at their own expense.

Chang Rongshan believes that EVUSHELD has a large application prospect in terms of the prevention of the new crown, such as the new crowns, or the high -risk infection with the new crowd (medical care, customs, airports, cold chains, etc.) The possibility of medical insurance. "

Photo source: Screenshot of the website website of Boao Leo City International Medical Tourism Pioneer Zone

The effectiveness of the Omikon strain still needs more data, and there is still room for improvement in the injection dose

On June 17, Xie Xiaoliang, the Biopic of Peking University Biomedical Fist Innovation (BIOPIC)/Cao Yunlong's research group published a paper online on Nature Magazine, and found that the Omikon mutaged plant BA.2.12.1, BA.4, BA.5 Xinya The type shows a stronger immune escape ability, and has a significant neutralization of the plasma after the recovery of Omikon BA.1 infected.

So, can EvushLed be able to withstand the challenge of BA.4/5?

The news on the official website of Astraco also shows that Evusheld has maintained effective neutralization of Omikon BA.2 strains, which dominate. According to the pre -clinical test data of the University of Oxford, EVUSHELD still maintains neutrality for the emerging Omikon BA.4/5 variant.

But for this conclusion, Chang Rongshan and Jin Dongyan have reserved attitudes.

Chang Rongshan said that fake virus experiments can not represent the clinical effects, and more convincing data also need to see the gold standards of antibody detection, that is, the PRNT50/80 of the new crown virus (geometric average and antibody titer), or or IC50 (semi -inhibitory concentration). EVUSHELD's effectiveness of the new BA.4/5 of the Omikon strain needs to be further tested. From the perspective of the injection dose, in the previous new crown and antibody therapy, the EVUSHELD dosage in the two hospitals in Hainan was the lowest.

Specifically, in July 2021, the new crown and antibody drug Casirivimab/IMDEVIMAB combination was obtained by the FDA urgent use authorization. It can be used for postponed prevention treatment of high-risk progress to serious COVID-19. The dose is 600mg++ 600mg; Lilly's similar neutralized antibody drug Bamlanivimab/Etesevimab was also urgently authorized in September 2021, with a dose of 700mg+1400mg.

From the perspective of pharmacokinetics, after the existing monoclonal antibody drugs are injected into the human body, its blood concentration will decrease according to the index curve, and the time required for half of the original value is called the half -life of neutralized antibody drugs.

Therefore, "In addition to drug affinity (that is, the ability of drugs and receptors, the higher the effect, the better the effect). The dose of neutralized antibody drugs is the core. The greater the dose, the better Crafts. "Chang Rongshan said.

In fact, on June 29, local time, the official website of the FDA has issued an announcement on the revision of the EVUSHELD dose. The article states that non -clinical data and pharmacokinetic models indicate that the dose of Evusheld was changed to 300mg of Shatvir Mid Midurate and 300mg West West After the Gaviku, the activity of the drug concentration to these sub -transformers can be maintained for 6 months.

Chang Rongshan said that in the absence of Omikon's mutant strains, the activity maintenance time of 150mg+150mg dose is likely to be less than six months. In the future, the EVUSHELD provided by Boao Super Hospital and Ruijin Hainan Hospital is in There is still a lot of room for injection dose.

Under the rapid iteration of the new crown strains, the regenerative elements mentioned above and the similar new crown and antibody drugs of Lili Lili have been suspended due to invalid Omikon. The new crown vaccine in the world also needs to be upgraded.

According to the study of Xie Xiaoliang/Cao Yunlong's research group, the plasma of the three -pin vaccine population has a significant decline in BA.2 and the neutral ability of BA.2.12.1 and BA.4/5. The neutral ability of plasma for BA.2.12.1 and BA.4/5 has also decreased significantly.

Considering that the currently listed MRNA vaccine is still effective in fighting Omircong's mutation strains. Chang Rongshan calls for the introduction of the MRNA vaccine as the next franchise to meet the needs of domestic customers; Jin Dongyan also believes that the MRNA vaccine should be promoted as soon as possible.

Daily Economic News

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