Crack 60 years of problems!For the first time, Anshe University published research results on Science by a communication unit

Sound -including music and noise -can reduce human pain, but the potential neural mechanism is still unknown.

On July 7, 2022, Zhang Zhi, China University of Science and Technology, Tao Wenjuan, Anhui Medical University, and the National Health Research Institute (NIH) LiUANYUAN joint communication published a research paper entitled "Sound Induces Analgesia Throughsia Throughsia Limic Circuits" online. The study found that the analgesic effect of sound depends on the low (5 decibels) signal -to -noise ratio (SNR) of the relative to environmental noise in mice. Multi -pole records of virus tracking, micro -end mirror calcium imaging, and free mobile mice show that the low signal -to -noise ratio inhibits the Valley from the hearing cortex (ACXGLU) to the rear nucleus (PO) and the abdominal nucleus (VP) Pinine can input. ACXGLU → PO and ACXGLU → VP circuit's optical genetic or chemical genetic inhibitory inhibitors simulate the analgesic effects induced by the low SNR sounds in the front paws and the low SNR sounds in the front paws, respectively. The artificial activation of these two circuits eliminates the analgesic effect of sound induction. In short, the study revealed the sound of the leather hill brain circuit behind the pain treatment through the role of pain treatment in pain treatment.

This is the first time that Anhui Medical University has published research results with communication units in Science.

As early as 1960, reports from dental surgery showed that music and noise could have analgesic effect. Music as a means of intervention can alleviate pain in postoperative and during surgery, and even clinically refractory pain. Because different types of music and even natural sounds can reduce pain to the same extent, people assume that the inherent features or background factors of music — that is, not just the music itself -it is assumed that these analgesic effects are driven. However, its working principle is still unknown.

Functional magnetic resonance imaging (FMRI) research shows that during the process of human exposure to music, activities in multiple brain areas that regulate pain treatment have changed. So far, the nerve substrate that supports cross-mode audio-somatosensory interaction is still unclear. The hypothache transmits multi -modal sensory information (including hearing and somatosensory), and connects to the painful areas of pain, and process the emotional motivation of sensory identification and pain through different Asian regions.

Compared to the low -intensity sound of environmental noise caused an analgesic among mice (the picture is derived from science)

It is worth noting that the activity of the somatosensory hypothalamus will be affected by the significant hearing stimulus of music and harmless hearing. Therefore, hill brain may act as a bridge for hearing body feel. However, the accurate cell type specific tissue and functions of the hill brain circuit that regulate the sound -induced analgesic are still largely unknown.

The study found that the analgesic effect of sound depends on the low (5 decibels) signal -to -noise ratio (SNR) of the relative to environmental noise in mice. Multi -pole records of virus tracking, micro -end mirror calcium imaging, and free mobile mice show that the low signal -to -noise ratio inhibits the Valley from the hearing cortex (ACXGLU) to the rear nucleus (PO) and the abdominal nucleus (VP) Pinine can input.

ACXGLU → PO and ACXGLU → VP circuit's optical genetic or chemical genetic inhibitory inhibitors simulate the analgesic effects induced by the low SNR sounds in the front paws and the low SNR sounds in the front paws, respectively. The artificial activation of these two circuits eliminates the analgesic effect of sound induction. In short, the study revealed the sound of the leather hill brain circuit behind the pain treatment through the role of pain treatment in pain treatment.

Review, editor: Da Ke

Copyright statement: This article is integrated from "Inature". The copyright belongs to the original author. The article is picked to academic communication. If it involves infringement issues, please contact us, we will modify or delete it in time.

- END -