New signal molecules of stimulating heads are expected to provide new therapies for male hormone hair loss

Researchers at the University of California Owen, USA, determined the precise mechanism of hair nipple cells to promote new hair. It is found that signal molecules named Scube3 can effectively stimulate heads. It is expected to provide new therapies for people's common hair loss -androgen hair loss. The research recently published in the online version of "Development Cell" magazine.

Circular nipple cells are a group of dermal -dermatocytes located at the base of the hair follicles, which plays a dominant role in the growth and development of hair follicles, cyclical regulation, and maintenance of hair growth. Although scientists have previously known that hair nipple cells play a key role in controlling hair growth, they know very little about activists.

The latest research and communication author Maxim Plikus said: "During the different stages of the life cycle of the hair follicles, the same hair nipple cells can send different signals: make the hair follicles in a dormant state or trigger the new hair. The natural SCUBE3 signal molecule is used to tell 'to tell' adjacent hair stem cells to start split, which indicates that it is a messenger of new hair. "

Researchers said: "We have developed a mouse model with excessive activation of hair nipple cells and excessive hair. By studying this model, it can be determined that Scube3 is an unknown signal molecule that can promote hair growth."

Further test also confirmed that Scube3 can activate the hair growth in human hair follicles. The researchers injected the trace SCUBE3 into the mice that transplanted the human scalp hair follicles and found that it could induce dormant human hair follicles and the surrounding mouse hair follicles to grow new hair.

Researchers said: "The data provided by these experiments show that Scube3 or its derivatives may be a very promising drug for the treatment ofrogen hair loss. ","

At present, the US Food and Drug Administration has approved nonselinamine and Minoidur to treat male hormone hair loss. Feibcamine is only approved for men. But these two drugs are not generally effective, and patients need to take medicine every day to maintain the effect. (Science and Technology Daily)

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