This three hospitals published the first science: stress?go to sleep!

Author:Scientific network Time:2022.07.02

Text | "China Science News" reporter Shen Chunlei

You quarreled with your friends, and the defeated side often put pressure on social failure. So, can the loser still sleep under pressure?

At least on the mouse, the result is yes. The stress activated the middle brain cells of the mouse, which not only promoted sleep, but also relieved anxiety caused by stress.

At first glance, it seems unreasonable. On July 1, the results of the above experiments were published in Science magazines in the form of thesis.

The first author of the paper, Yu Xiao, a researcher at the Empire Institute of Technology, told the Journal of China: "Our research found the brain mechanism of linking sleep and stress. Simply put, sleep can help relieve stress."

"Sleep can be used as a means of intervention, prevention or treatment of psychiatry caused by stress." Dong Hailong, author of the dissertation and communication professor at Xijing Hospital, said that in the future, the two parties will also carry out in -depth cooperation research to find mental diseases such as treatment anxiety and depression. Target. "This is also the first science paper in Xijing Hospital.

The middle brain -specific circulation is caused by inducing recovery sleep prevention of severe stress stress.

Sleep, drive away the pressure

In daily life, everyone has experienced some serious stress stimuli.

Some pressures may originate from the fear and frightening brought by the external environment, some pressure may originate from social conflicts, and some pressure may originate from the burden of work and family ... These pressures will more or less cause uncomfortable psychology such as anxiety Status, even adverse reactions of the body.

Zhao Guangchao, the first author of the paper and the attending physician of Xijing Hospital, pointed out that medical abnormalities caused these adverse factors to cause negative heart and body abnormal reactions as stress. "How to control the stress well and effectively relieve the state of the mind and body, which is especially important for people's health."

In previous studies, scientific researchers found that after stress stress stress, sleep will change, such as showing insomnia and dreams.

As an important way to regulate the health state as a body, can sleep play a positive role in regulating the abnormal emotions after stress stress stress? For a long time, this has been a question that researchers in the field of neuroscience and psychiatry have tried to answer.

To this end, the Dong Hailong team and the Professor Franks Wisden team of the Imperial Institute of Technology launched a collaborative research. The use of genetically modified mice as an experimental object, and found that neurons in the brain played an important role in regulating sleep.

The research team's mouse social frustration model mentioned at the beginning of this article confirms that stress can continue to activate a special GABA in the middle of the brain and abdomen to inhibit neurons. This nerve cell can increase sleep time and effectively relieve the anxiety caused by social pressure.

Zhao Guangchao told the Journal of China: "This kind of special nerve cells can also reduce the reaction of the whole body by suppressing the release of a cortex release factor (CRF) in the lower mound brain."

In other words, sleeping well, you can drive away the pressure and anxiety.

When I encounter pressure, I still get up early when I sleep more

"I'm fine, I want to go to soak tonight!"

After encountering stress, some young people often choose some decompression methods that they agree with, such as soaking, drinking, and staying up late. Dong Hailong did not agree with this. He told the China Science Journal: "At this time, the body needs to restore sleep, instead of buying drunk and staying up late. If it is not well controlled, it will cause anxiety and even depression."

He also said that the original intention of this study was not to reveal a disease, but to find important physiological phenomena and mechanisms.

So, after the pressure is generated, should I sleep more or get up early? This is also a long -time issue.

Zhao Guangchao found from clinically that the method of dealing with the problem is not unique, but the research results of this paper show that when social conflicts occur, sleeping more can cause the body to form endogenous protection.

The cooperation between Dong Hailong and Franks Wisden can be traced back to 2016. Previously two research results were published in Nature Neuroscience and Molecular Psychiatry in 2018 and 2021.

To calculate this is the third paper published by the two parties, and it also continues the previous research progress.

Yu Xiao introduced: "Nature Neuroscience The neurons used in the thesis study were the same as the study, which activated or suppressed the neuron to have a strong response to sleep or awakening. Can't simulate the real physiological environment. "

Zhao Guangchao was the author of the Molecular Psychiatry papers. He introduced the experiments at the time: "We found a special phenomenon, and the brain area was damaged, and mice would have mania. The couplet also made us realize that the brain area has an impact on the spirit and introduced it to the latest research. "

Looking forward to the next results come out

The review expert believes that this is a very interesting discovery, and the process from submission to the publication is also very smooth.

Yu Xiao introduced that the Science editorial department was transferred to a professional review expert within a week and gave a modification and guidance on the paper.

"We have not been reviewed by the reviewer. On the contrary, under the guidance of the reviewer, the thesis presentation is more complete and more rigorous." Zhao Guangchao said, "The reviewer also gave some inspirational tips." Why chose to choose Submit science? Dong Hailong introduced: "Because the previous two papers have been voted for professional journals, this time we directly chose the science of comprehensive journals. I did not expect that the feedback was so exciting."

However, the paper encountered the epidemic in the United Kingdom and Xi'an in the draft. Zhao Guangchao still remembered that the team members stayed spontaneously in the laboratory at that time. "Everyone is worried that once they leave, they will not enter the laboratory."

It is understood that the above -mentioned studies have initiated a key project from the National Natural Science Foundation of China, and at the same time, they have also received support from many scientific research funds between China and Britain.

Through these years of cooperation, Yu Xiao also felt the progress of domestic scientific research institutions. He said: "This study needs to use high -precision detection technology. We have received support from Li Yulong's team of Li Yulong, a researcher at Peking University IDG McGen McGen Institute."

"Science does not have national borders. Our research team is summoned by the direction and problems of science. Everyone jointly cooperates with the problem of human unknown and difficult to solve the problem of human beings." Dong Hailong said that the cooperation between the two parties is still continuing, maybe the next paper will be Send Nature.

Thesis link:

https://www.nature.com/articleS/S41593-018-0288-9

https://www.nature.com/articleS/S41380-020-0810-9

https://doi.org/10.1126/science.abn0853

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