New Studies ｜ New crown vaccine is released in the elderly with hypertension and diabetes elderly people!

On June 25, "VACCINES" published the "Evaluation of Immunogenical and Safety of Vero Cell" published by the Chinese Pharmaceutical Group's Chinese Bioscope in China. -Derived Inactivated Covid-19 Vaccine in Older Patients with Hypertension and Diabetes Mellitus). The results of the study show that after the two doses of the Chinese biological new crown vaccine, the new crown and antibody yang rotation rate of all the subjects is 100%. Health control group; uncompromising serious adverse reactions related to vaccination.

The study was completed by the Chinese Pharmaceutical Group China Biological and Beijing Biological Products Research Institute and Hunan Provincial Disease Control and Prevention Center, Guizhou Provincial Disease Control and Prevention Center, Fujian Provincial Disease Control and Prevention Center, Peking University and other institutions and units. The chief scientist of the "863 Plan" vaccine project of the Ministry of Science and Technology, Researcher Yang Xiaoming, Chairman of China Biology, Director of the Strategy Research Center of Public Health and Major Epidemic Prevention and Control of Public Health and Major Public Health of Public Health. Zhang Yuntao, Chen Haiping, Manager of the Medical Affairs Department of the Marketing Center, and Professor Lu Yan of the School of Public Health of Peking University as a common first author.

In this study, 1440 subjects ≥60 years old were divided into 4 research groups according to their health: hypertension group, diabetic group, combined disease group (at the same time with hypertension and diabetes) and health control groups. All subjects were vaccinated with two doses of the new crown vaccine produced by the Institute of Biological Products of China Biological Beijing. The two doses were 21 days. 28 days before the first and second doses were vaccinated to detect the new crown neutralized antibody titer, and distributed blood pressure meters to the hypertension group and the merger of the disease, and distributed the blood glucose meter in the diabetic group and the combined disease group. The volatility of blood pressure and blood sugar value after monitoring vaccine.

The immune original results show that the rotation rate of the new crown and antibody yang of all the subjects after the two doses is 100%, and the antibody yang rotation rate of the hypertension group, diabetes group, and combined disease group is not inferior to the health control group Essence The new crowned rear antibody GMT of the high blood pressure group, diabetic group, combined disease group, and health control group was 73.41 (95% CI 67.24 ~ 80.14), 69.93 (95% CI 63.59 ~ 76.89), 73.84 (95% CI 66.70 ~ 81.755555555555 ) And 74.86 (95% CI 69.49 ~ 80.64), there is no statistically significant difference between GMT in the group (P = 0.722), and the high -blood pressure group, diabetic group, and merging disease group exemption all non -inferiority is healthy than healthy health. Control group. After the subjects are layered according to their age (60-69 years and ≥70 years), their antibody yang rotation rate is similar to the after-free GMT results to the above results.

▲ The picture above shows that the subjects over the age of 60 and or above are not statistically significant according to the new crown and antibody GMT levels of the 4 research groups after the age and gender layers.

The safety results show that the incidence of adverse incidents after two doses of two -dose vaccine in high blood pressure group, diabetic group, combined disease group and health control group was 11.93%, 14.29%, 12.50%, and 9.38%. Significance (p = 0.185). The severity of the reports of the report is slightly mild, and there are no serious adverse events related to vaccination.

The above research results confirmed that the new crown vaccine has good immunogenicity and safety in people with hypertension and diabetes in the age of 60 and above. After the vaccine with hypertension and diabetes, the blood pressure and their blood pressure and their blood pressure No significant fluctuations in blood glucose value. In order to encourage the elderly with basic diseases (such as high blood pressure and diabetes) to complete the new crown vaccination in time to provide strong data support, it will help improve the coverage of new crown vaccination in the elderly in China, and establish an immune barrier for the fragile group of the elderly.

Source: Chinese creature

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