alert!This common medicine will increase the risk of fractures and diarrhea!Many people don't know about it

Experts in this article: Pan Kunming, a master's degree in pharmacy at Peking University, the supervisor pharmacist in Zhongshan Hospital affiliated to Fudan University

When you buy or take medicine, do you have the habit of reading the drug manual carefully? Pharmaceutical ingredients, methods, adverse reactions, and precautions in the manual, etc., are actually very important! With more research and evaluation, these contents have been constantly updated.

Recently, the State Drug Administration issued an announcement on the amendment of the inhibitors of proton pump inhibitors:

Screenshot of the official website of the State Drug Administration

According to the results of adverse drug reactions, in order to ensure the safety of public medication, the State Drug Administration decided to decide to inhibit agent drugs (including Ome Pipazole oral dip, Omeprazole injection, and anemio for injection Meterprazole sodium, osoma oral preparations, chimotoprazole injection, Lanzozole oral preparations and injections, labeboprazole oral preparations, sodium for injection The content of the injecting of Epitzole sodium) is revised.

Revisory requirements

Adverse reactions and precautions include the following content, and describe it in detail:

Hip joint, wrist joint or spine fracture

Difficultylobura related diarrhea

Hypomitrobia

Proton pump inhibitors are also the most commonly used "gastric medicine". By suppressing gastric acid secretion, due to fast effect, strong and long -lasting effect, good safety, and tolerance, it is widely used in treating acute and chronic digestive acid -related diseases, including gastric ulcer, duodenal ulcer, gastroesophageal reflux reflux Disease, gastrinoma, upper digestive tract bleeding, eradicating pylori infections, and stress stimuli gastric mucosal disease. It is one of the most widely used drugs at present.

The names of such drugs are characterized by the word "Lazole". There are currently 6 drugs in my country that are listed in this manual.

Screenshot of the official website of the State Drug Administration

In fact, the State Drug Administration issued a safety warning in 2015, and this time it put forward clear revision requirements.

Increase the risk of fracture, especially the elderly

Studies have shown that the risk of fracture caused by hip, wrist joints, or spine osteoporosis will increase the risk of hip, wrist joints, or spine. Patients with high doses (daily administration multiple times) and long -term (one year or longer) treatment have increased risk of fracture.

Lazole-like drugs may increase the overall risk of fractures by 10%-40%. Patients with osteoporosis risk should be treated in accordance with the current clinical guidelines and doctors' suggestions, and should consume sufficient amounts of vitamin D and calcium.

Difficult risk of diarrhea infectious diarrhea increases

When treated with barazole drugs, gastrointestinal infections may be slightly increased, such as Salmonella, Candacar, and Difficultylla infection; in hospitalized patients, they should be particularly worried about difficultylobia infection. If the diarrhea is not good, it may be related to the threzole drugs, and the drug needs to be discontinued in time.

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Rare hypotamidity

Patients who received ramazole drugs for more than 3 months, especially patients with or more patients with or asymptomatic low magnesium ledmia reports.

During severe magnesia, severe manifestations are fatigue, rigidity, hands and feet twitching, convulsions, dizziness, mental chaos, seizures, convulsions, dizziness, and arrhythmia. However, the above symptoms are often not obvious at the beginning and are easily overlooked.

Most patients' hyperthyroidism is improved after magnesium supplementation and discharge drugs.

For patients who need to be treated for a long time, or patients who use high -pellets, or other patients who can cause hypertrophy, diuretic drugs (such as diuretics), blood and magnesium levels should be monitored regularly during the medication.

What other adverse reactions need to be paid attention to?

Causes acute interstitial nephritis: It is usually due to a special hyper -sensitive reaction, and the medicine is immediately discontinued once it occurs.

Causes vitamin B12 deficiency: long -term (such as more than 3 years) daily use may lead to vitamin B12 deficiency.

Causes skin and systemic lupus erythematosus: Most patients are relatively mild, with only rash. Once you find that you should seek medical treatment in time, most patients will improve within 1-3 months after stopping the medicine.

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The overall effect and good safety of the Lazole -like drugs are good. It is necessary to pay attention to the method of taking:

In order to play the greatest efficacy, thremazole drugs should be taken 30-60 minutes before breakfast.

The enteric -soluble tablets (capsules) need to swallow the whole piece, not chewed or crushed, so as not to release prematurely in the stomach and affect the efficacy.

Is there so many adverse reactions, can I still take medicine normally?

First of all, do not need to worry too much. The newly added adverse reaction is related to long -term medication (more than one year), and the short -term medication does not occur; and the initial stage of occurrence is slightly mild, and most of the time -stop drugs can be relieved.

For long -term drug people, pay attention to regular monitoring corresponding indicators, once it is found to discontinue the medicine in time. For example, fracture risks, high -risk people can monitor bone density or calcium supplementation in advance according to the specific situation.

Reason

Adverse reactions often follow

Maintaining proper vigilance

Early prevention, intervene in time

Avoid more serious problems

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