1.2 million needle anti -cancer?Henan's first cancer patient who received CAR-T cell therapy is now the same

He was unfortunate, and he was gently obtained by acute B lymphocyte leukemia.

He was hospitalized more than 30 times, more than 60 bone marrow puncture, hematopoietic stem cell transplantation, 3 times in the position ... So far, he dare not recall this difficult anti -cancer experience.

He was lucky again.

When his life entered the "countdown", he had the opportunity to receive CAR-T cell therapy. The cancer cells disappeared, and he "picked" a life ...

Six years ago, what was the first cancer patient who received CAR-T cell therapy for Henan? What is it now? Top News · Henan Business Daily reporter exclusively interviewed to take you into his story.

Nightmare

The second child daughter for more than two months

At the age of 24, he was diagnosed with cancer

One day in October 2013, 24 -year -old Zhao Shuaijie returned to the dormitory from the car repair factory. He wrapped his clothes while walking, and there was a trace of work in the seam of his nails.

The dormitory is on the second floor, and colleagues walked up effortlessly, but he had to "climb the stairs" hard.

After returning to the dormitory, I was panting. I couldn't breathe up for a long time, and my body was weak.

When sitting on a stool to rest, he remembered that his colleague asked him "how yellow his face was so yellow", and his state was too bad, so he went to the hospital for examination alone.

"Have you ever had leukemia before? Suspected of leukemia, let you go to a large hospital and check it out?"

Hearing this, Zhao Shuaijie was stunned, his mind was blank, and he could only calm down as much as possible. Of course, there was a little luck to comfort himself in his heart: the doctor said, just doubt.

After coming out of the hospital, he first called the boss and settled about 7,000 yuan.

Later, he called his father's phone, and his father said in silence for a while: "Come back first ..."

Zhao Shuaijie was calm at the time, until he heard his wife's cry, he couldn't hold it.

"My son is more than one year old. The daughter has just finished the full moon wine. I want to work in Wenzhou to make money. Who knows that I have encountered it after more than a month." He told the top news · Henan Business Daily reporter that the night was taken by car. Back to his hometown of Shangqiu, did not go home, went to the hospital for an examination.

The days of waiting for the results of the inspection are difficult. In those two days, Zhao Shuaijie did nothing, but prayed that he could wait for a good news, but the final waiting was the diagnosis.

"How can it? No one at home has cancer at home. I usually have a good body in my body, rarely a cold, and I am still the strongest ..." Zhao Shuaijie's brain turns, so I think about everything, so I think everything. I ca n’t figure it out, why do I get this disease? In addition, the economic conditions are not good. He said, “There is a heart that I want to die at that time!”

Unlucky

Nothing to kill cancer cells twice

If you get sick, borrow Qian Zhi.

Zhao Shuaijie recalled that relatives and friends have borrowed them. A family of 20,000 or 30,000. When there is no money, they will be discharged first, and they will be hospitalized when they have money.

In June 2014, he successfully matched his brother who graduated from the university and performed the first hematopoietic stem cell transplant. Unfortunately, two years later, the cancer was recurring, and the second hematopoietic stem cell transplantation was made, and it ended in failure.

"I was scared at first, and I was numb. I thought about it. It would be a day, but I just suffered my wife." Zhao Shuaijie said that during the whole hospital, his wife took care of herself while taking two children. What impressed me the most was that the wife held one in her arms and held one in her hand. "The nurse said, my wife hid behind the door every day and cried."

After the second relapse, Zhao Shuaijie knew that his life was about to enter the countdown. He also smiled and said, "You see, this chemotherapy is useless to me. A few pounds, you can eat. Even the two transplants have not been able to kill cancer cells. "

"To be honest, I was waiting to die at that time." Zhao Shuaijie was so gray, and I didn't know that the final opportunity was waiting for him.

Turnover

The last chance

It is understood that as early as 2012, Henan Cancer Hospital integrated the resources of the Department of Hematology, Immunotherapy, Central Laboratory, Inspection Division and other departments, and established a platform including CAR-T cell preparation, biological activity testing and clinical safety assessment. Carry out the foundation and clinical application of CAR-T cell therapy. In 2016, related departments such as Henan Cancer Hospital and other related departments were carrying out the exploration and application of CAR-T cells to treat the innovative technologies of hematological tumors. After learning about Zhao Shuaijie's situation, after communicating with his family members, on August 5, 2016, under the organization of Song Yongping and Gao Jianli, deputy dean of Henan Cancer Hospital, the Department of Hematology and Biological Immunotherapy worked closely to implement CAR for him. -T cell therapy.

"I didn't know anything at that time. I just remember that after that treatment, the high fever exceeded 40 ° C, and it burned for more than 100 hours. The family members said that there was a blood clot in my eyes, and I was put on my body. Nutritional solution is maintained. "Zhao Shuaijie told the top news · Henan Business Daily reporter, and later learned that it was a clinical study, not charging. If you do it now, you have to spend 1.2 million yuan. "No one wants to be a 'little white rat", but there is no other way at that time. I always have to try it. I understand the mood of the family members at that time. "

Fortunately, the result is good.

According to Gao Quanli, after half a month of treatment, he could not detect leukemia cells in his body. It's the 6th year. "There is a sentence in medicine. If tumor cells cannot be detected for 5 consecutive years, it can be said that it is completely cured."

newborn

Be sure to make your wife and children better in the future

On June 22, Zhao Shuaijie came to the hospital to review again. Without medical staff guidance, he curled up skilled and standardized, waiting for bone marrow puncture.

"My family urged me to review it a month in advance. It took about 5,000 yuan to come once. I really didn't want to come in my heart, but I also wanted to let my family feel at ease." In addition, he also told Top News · Henan Business Daily reporter that what he didn't want to come from did not want to come Another reason is that the hospital has a psychological shadow. "Hospitalized more than 30 times, bone marrow puncture more than 60 times, hematopoietic stem cell transplantation, 3 times in the position ... This experience can be affected by no one. Now when you come to the hospital The taste of water wants to vomit. "

I also think of the patient in the bed next door.

"He is one year older than me. When I entered the position for the last time, he entered the ICU, and soon the generations left ..."

Zhao Shuaijie said that he is lucky than many people, and he will make good money in the future to make up for his family.

"24 years old, it is a good time. But I am sick. I missed the golden period of accompanying the child, and it took a lot of money to owe foreign debt. I have already had a car with me, and I still buy it in the county seat. I still buy it in the county seat. The room ... "He said with emotion, and he would be envious before, but now he wants to open it. I feel that as long as there is a good body, the family is safe and healthy.

Today, Zhao Shuaijie has worked for two years. He has been working in aluminum alloy and can earn more than 5,000 yuan a month. His wife can earn money for a little work without delaying the child.

He said that first setting a small goal for himself, after returning foreign debt, buy a house in the county seat.

"As his wife often says, it will definitely get better in the future." He firmly believes that all the haze that appeared in life will eventually be meaningless to walk, and then regain new life.

hope

More patients are new through CAR-T cell therapy

In recent years, CAR-T cell therapy has been widely valued. It has made breakthroughs in the treatment of blood system tumors, especially lymphoma.

According to the introduction, since 2016, Henan Cancer Hospital has already had hundreds of patients with hematological tumor patients related to the CAR-T related clinical trials in the hematology department and achieved good results.

However, Wei Xudong, director and chief physician of Henan Cancer Hospital, said, "It is important to emphasize that CAR-T therapy for treatment is mainly concentrated in acute lymphocytic leukemia, lymphoma, and multi-myeloma. CAR-T therapy of tumor is under clinical research. "

Gao Quanli also told the top news · Henan Business Daily reporter that when many people heard the "anti -cancer needle", they thought that like vaccine, they could stand up and go ... Actually, the whole treatment process was not, the entire treatment process It is also complicated and risky.

He introduced that the following steps are roughly performed: T cells from the patient's body-using genetic engineering technology to transform it into CAR-T cells-a large amount of AT-T cells-return it back to the patient's body for treatment.

The principle is probably that T cells are a type of immune cells in the human body and one of the natural defense lines for human body to resist pathogens. Natural T cells are "ordinary arms", and Car-T is equivalent to "special forces".

When encountering specific tumor cells, the CAR-T cells in the patient's body will be activated, a large number of proliferation, and a large-scale killing of tumor cells such as white blood cells that attack and kill lesions to achieve the treatment effect.

Gao Quanli said that from the beginning of treatment to the discharge standard, it takes about 3 weeks. "But in the treatment process, there are also severe adverse reactions to cause death." He reminded that this treatment not only has high requirements for doctors, testing requirements, and even medical levels. Moreover, patients are patients. Its physical condition is also important.

Finally, I hope that more and more patients will get new students through CAR-T cell therapy, and the technology of treating cancer is becoming more and more developed.————————————————————————

Source: Henan Business Daily

- END -