29 -year -old guy realized CNS Grand Slam!He comes from this "boast" research group

Author:Scientific network Time:2022.09.28

Text | "China Newspaper" reporter Li Chenyang

Young scientific researchers Xu Peiyu, because they were less than 29 years old, realized "CNS (Cell, Nature, Science, SCIENCE) Grand Slam", and was interviewed and reported by my hometown media some time ago. Xu Huaqiang, the mentor of his doctor and researcher of the Shanghai Institute of Pharmaceuticals of the Chinese Academy of Sciences, reposted the report for the first time, and also sent a emotion: "Be a mentor, there are a few such students in my life, enough!"

Just roll over Xu Huaqiang's circle of friends, just like a "student exaggeration." Among his students, some people became the youngest "Shanghai Science and Technology Youth Leading Plan" winner. Some people just won the special award of the 2022 Chinese Academy of Sciences. Some people joked that Mr. Xu's circle of friends was too "Versailles."

When a reporter from the China Science News contacted Xu Huaqiang, he was still enthusiastic "Amway" his own students: "You go to interview these young people, they are particularly good!"

"He is the person who let me open a trick to scientific research"

From February 2021 to August 2022, in just one and a half years, Xu Peiyu published a Cell paper, 3 Nature papers and a science paper. When he reached CNS Grand Slam, he had not passed his 29th birthday.

Xu Peiyu

On July 1, 2022, Xu Peiyu came to the Massachusetts Institute of Technology and became a postdoctoral in the research group of Zhang Feng, a famous Chinese scientist. In this world -renowned scientific research team, he embarked on a new journey of scientific research.

"The gene editing research I do now is very different from the structural biology research I have done in Shanghai's drugs. I want to try some new things. But what does not change is that I always pay attention to topics related to diseases and hope that I can I can Make a little contribution to the development of drugs and development treatment. "Xu Peiyu said.

In an interview with the China Science Journal, the guy of the appearance of Swen laughed and said that he did not think about the three top issues of "gathering" at first. "After all, when contributing to academic journals, there are often situations such as rejection and changes." He said, "This situation is really a bit coincidentally."

After graduating from Jilin University undergraduate, Xu Peiyu was admitted to the Shanghai Institute of Drugs, the Chinese Academy of Sciences in 2015, and directly studied for a doctorate degree.

His instructor Xu Huaqiang has successively carried out research work at Duke University, Texas University, Massachusetts Institute of Technology, Glaxor Institute (later consolidated as GlaxoSmithk), Wenande Institute and other universities and institutions. Essence Xu Huaqiang's early research direction was nuclear heating. Around 2000, the world's first G protein coupling (GPCR) structure was successfully analyzed. He keenly noticed that the huge potential contained in it decisively stepped into this field that was not mature at the time.

In 2010, Xu Huaqiang returned to China and joined the Shanghai Academy of Sciences Shanghai Drug Research Institute to create a drug target structure and function center, mainly to carry out GPCR structural biology research and drug research and development. Over the years, he has led a team to analyze the three -dimensional structure of nearly 1/3 of the human body and a series of important GPCRs, and also participated in the research and development of GPCR drugs such as ADVAIR (Schuro) and AVANDIA (Rogler).

Xu Huaqiang

When Xu Peiyu joined Xu Huaqiang's research team, the team was in a period of "charging". In the first four or five years, his scientific research did not do well. He spent the most hard -working topic. He was the first to publish an article by foreign colleagues, and he had to adjust his direction as a last resort. At the same time, some technologies in the field have also troubled him.

With the guidance and encouragement of Xu Huaqiang, Xu Peiyu and his partners solved these key technical problems in two or three years. Almost at this time, Xu Huaqiang's research team established a cooperative relationship with the Zhangyan research group of Zhejiang University, and has a qualitative leap in freezing electron microscope technology.

After many years of accumulation, it encountered Tianshi, geographical, and people, including Xu Peiyu, and the entire research team ushered in the blowout period of results.

Although he had left the Shanghai Pharmaceutical Institute, Xu Peiyu mentioned that Teacher Xu Huaqiang was full of feelings. "He is particularly nice and always communicates with us with an equal attitude."

"Puzhuo Copywriter" that has never been late

Duan Jia, 26, just graduated from a PhD in July this year. Now he has stayed in Xu Huaqiang's research group to become an assistant researcher.

Duan Jia

She recalled that when she chose a graduate major, she asked about the situation to a school sister. I heard that Mr. Xu was good to the students and the atmosphere of the laboratory was good, so he no longer hesitated and walked into this laboratory.

As soon as she arrived here, she saw Teacher Xu's "release" style. "He never criticized anyone, nor staring at the students' commuting time and experimental progress. In which student holiday is still doing experiments, he will persuade the other party not to be busy and go out to play."

When Duan Jia was young, his parents had strict control, so that this well -behaved girl also had a small rebellious. Instead, in this extremely free research group, she can coordinate the work and leisure time, and the efficiency and enthusiasm can be greatly improved.

Duan Jia won the first place of the year with his outstanding performance. Xu Huaqiang was very pleased, and gave her a "very difficult topic" when he turned his hand: "Since you are so good, you must challenge it!"

Duan Jia knew that the reason why Teacher Xu gave this heavy responsibility to her, in addition to believed in her ability, was also because her existing achievements had reached the doctoral graduation criteria. Even if this problem cannot be done, it will not affect future graduation. These subtle care, "Students are in their hearts." So far, Duan Jia has published two Nature papers in this "difficult subject". In addition, she also won a series of honors such as the Wu Rui scholarship, the National Scholarship, the "Dean Special Award" of the Chinese Academy of Sciences, the outstanding doctoral graduates of Shanghai, the "Star of the Future of Innovation in the Future" of Shanghai, and the Shanghai "Modeling Model".

Unsurprisingly, Xu Huaqiang "showed off" in the circle of friends again, saying that she was "clever, ordered to become gold." Duan Jia took a screenshot of these friends circles and sent it to his parents.

Recently, Xu Huaqiang's "exaggerated list" has been frequently appeared in Xu Huaqiang. He has just been elected "Shanghai Science and Technology Youth 35 Leading Plan" and is the youngest selected person, ranking the strategic direction of "facing the lives and health of the people". His main research object is GPCR, which is closely related to the nervous system. He has published two papers in Cell magazine. One of them is also selected as a cover story. A series of research results he have achieved is Parkinson disease and other neuropathic diseases have provided an important basis.

In this regard, Xu Huaqiang's "Puwen Culture" is never late: "29 years old, what a good year, since ancient times, heroes!"

"Our group is super heartpower!"

Xu Huaqiang team

Throughout the Shanghai Pharmaceutical Institute, Xu Huaqiang's research team is a striking landscape. It is often Mr. Xu to take a walk, and Hu La followed a large group of people. Everyone said and laughed. The topic is not limited to scientific research. Xu Huaqiang also often asked everyone in the WeChat group what I wanted to eat, and then bought it back while riding a bicycle to exercise.

"Our group seems to have a kind of centripetal force, and many people want to come!" Duan Jia said proudly.

In Duan Jia's opinion, the most charming place in this group is really not a big harvest in the top issue, but the atmosphere that makes people feel warm and healed.

Structural biology is a very competitive area. Most students in the group have encountered the "sedimentation" paper by others. When Duan Jia encountered this situation for the first time, "the heart was relatively fragile", crying in Teacher Xu's office for a long time. Xu Huaqiang's first response was to apologize to her, saying that she was guilty and did not care enough about her work. Next, he encouraged Duan Jia to come out of depression and invest in new topics as soon as possible.

"Anyone who is familiar with me knows that I am a bit full of emotions and used to cry easily. But now I don't cry very much. In this warm environment, I grew up."

From 2018 to 2019, Zhuang Youwen exchanged at the Wenande Institute in the United States for a year. Xu Huaqiang was also in the United States at the time. On one occasion, the rare bad weather swept the local area. First, it was a crazy masterpiece at the seventh or eight, and then the snowstorm was made. At around 6 pm, Zhuang Youwen received a call from Teacher Xu in the laboratory.

Zhuang Youwen

Xu Huaqiang asked him: "How do you plan to go back?" Zhuang Youwen looked out the window and knew that his bicycle had been riding, so he answered: "I will wait for the snow and snow to return."

"That's not OK, it's too dangerous, you wait for me." Putting down the phone, Xu Huaqiang rissed the snowstorm and drove to the laboratory where Zhuang Youwen was in for more than an hour, sent him home, and then drove back alone. Zhuang Youwen was worried along the way, and sent a lot of news until he confirmed that Mr. Xu returned safely before he breathed a sigh of relief.

"I think Mr. Xu is our nobleman." Zhuang Youwen said.

Xu Huaqiang often said: "I think to cultivate a student is to give them sufficient trust and respect, so that they can develop as much as possible here, and at the same time work hard to solve the really important scientific issues."

In the descriptions of these teachers and students, compared with growth and knowledge, publishing papers seems to be just a "by -product".

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