Professor Wang Xiaoyi, the First People's Hospital of Huzhou City, has made new progress in the team

Professor Wang Xiaoyi of the Department of Nephrology of the First People's Hospital of Huzhou City has been deeply cultivated in the field of diabetic nephropathy in recent years. Teams such as professors have studied in -depth research in the field of diabetic nephropathy in recent years. They have achieved fruitful results in the direction of susceptible genes, non -invasive diagnosis, and prognosis judgments of diabetic nephropathy. Related results were published in well -known international academic journals.

Diabetic nephropathy (DN) is confirmed that the previously relied on kidney puncture biopsy, and renal puncture biopsy has always been an indispensable "gold standard" in a differential diagnosis with non -diabetic nephropathy (NDRD). Professor Wang Xiaoyi and other teams, through the pathological data of 220 cases of type 2 diabetes combined with a large amount of protein urine patients, combined with the main clinical and laboratory data, found that diabetic nephropathy and non -diabetic nephropathy clinical characteristics, diabetic duration, diabetes properties Retinal disease, systolic blood pressure, urine red blood cell count, 24 -hour protein urine quantitative, serum albumin, hemoglobin nitrogen, serum creatinine, EGFR, hemoglobin, and low density lipoprotein are significantly different (P <0.05), of which The two items of retinopathy and duration of diabetes are of great significance to differential diagnosis. Further use the ROC curve analysis and find that the combination of retinal lesions, diabetes duration, serum albumin and contraction pressure: DN diagnosis has the highest specificity and sensitivity. Related results were published in the internationally renowned academic journal "Diabetes Research and Clinical Practice". (IF 8.18).

Recently, the team of Professor Wang Xiaoyi and Professor Chen Jianghua, Jiang Hong and other teams through non -targeted LC/MS conducted a cross -section research on 1043 plasma metabolites, and determined the severity of proteinuria and the differences between metabolic products. Essence The results were repeated in the independent horizontal queue of 83 individuals. Diabetes and diabetic nephropathy with different protein urine shows different metabolic product models. Two interesting tetrapeptides (ASN-MET-CYS-Ser and Asn-Cys-PRO-PRO) cycle levels increase with the progress of diabetic nephrotic urine. These findings emphasize the serum metabolic group to provide us with a new biochemical perspective to determine biomarkers for the progress of some clinical -related diabetic nephropathy. Related results were published in the internationally renowned academic journal "Frontiers in Medicine" (IF 5.058).

At present, the research of Professor Wang Xiaoyi's team in diabetic nephropathy is still advancing. Professor Wang Xiaoyi said that the achievements of these achievements are inseparable from the team of Professor Chen Jianghua in the First Affiliated Hospital of Zhejiang University School of Medicine and other medical institutions in the province. Cooperate with the collaboration between the collaborations.

(Supply: Professor Wang Xiaoyi, Department of Nephrology, Hospital of the First People's Hospital of Huzhou City)

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