31 -year -old guy diagnosed Alzheimer's disease. Will this disease be inherited?

September 21 this year is the 29th "World Alzheimer's Day". According to data on the press conference of the National Health and Health Commission held on September 20, there are about 15 million dementia patients in the age of 60 and above in my country, of which 10 million are Alzheimer's patients -this commonly known as "Alzheimer's disease" The disease is the fifth cause of death in my country.

"Just like you stand by the sea alone, the waves are gone, and everyone is gone." Peng Mei News interviewed several patients and family members. In their description, there was helplessness of time and space. The moment the family was crying, there was no power to be uncertain in the future.

"Although it cannot be cured, the early diagnosis and active intervention can control the development of the disease." The theme of "Alzheimer's Day" this year is "Knowing and Preventing Early Wisdom". Doctors said that they have never stopped exploring the pace. Essence

At the age of 29, there were symptoms such as decreased memory. Two years later, he was diagnosed. Hangzhou 31 -year -old guy Kobayashi (pseudonym) was a family of family Alzheimer's disease. He asked the doctor: Will Alzheimer's disease happen? Will this disease family inherit?

"Kobayashi is a very few family patients with Altzheimer's disease and belongs to early hairstyles. From a genetic perspective, whether early or late hairstyles are closely related to genetic factors, there are high hereditary." Professor Wu Zhiying, Director of Medical Genetics Section of the Second Hospital, told Peng Mei News.

At the age of 29, Kobayashi was visited due to insomnia, memory loss, etc., and the condition did not improve significantly after the symptoms. He moved to neurology and psychiatry, and he could not get satisfactory treatment. The memory was further decreased and his temper was increasingly irritable. This year, Kobayashi found Wu Zhiying's consultation, saying that in recent years, memory has declined more and more seriously. In the noisy environment, it has been manifested by irritability. There are also abnormalities. "The results of the head nuclear magnetic resonance reminded that Kobayashi has mild brain atrophy and hippocampus atrophy.

"It is a rare family Alzheimer's disease." Wu Zhiying judged. After the genetic testing, the Psen1 gene of Kobayashi has a mutation. The mutant gene is one of the pathogenic genes of family Alzheimer's disease.

"Isn't Alzheimer's disease all happen to the elderly?" Kobayashi couldn't figure it out.

Wu Zhiying explained that Alzheimer's disease was mostly distributed. Only a few were family. Family Alzheimer's disease was mostly early before the age of 65. In addition to memory disorders, such patients are prone to non -typical symptoms, such as Language, vision or emotion-behavior change, etc.

The current research has been clear that the early aging protein 1 (PSEN1) gene and the other two starch -sample forefront protein (APP) genes and early aging protein 2 (PSEN2) genes are all pathogenic genes. These three gene mutations are rare among the crowd, accounting for less than 1%of all Alzheimer's patients.

Wu Zhiying told Peng Mei News that the common late hairstyle Alzheimer's disease is also closely related to genetic genes. So far, more than 50 genes are related to late Alzheimer's disease, and there are many mechanisms, such as immune inflammation and cholesterol metabolism. Among them, the most related genes related to the late Alzheimer's disease are lipoprotein E (APOE) and other genes. The risk of people with APOEEε4/ε4 is nearly 15 times compared to normal groups.

"From a genetic perspective, it is highly hereditary. It is not to say that someone in the family is sick, and the children and juniors will become ill. It is also closely related to environmental factors. It is also necessary to comprehensively analyze the probability of individual incidence in the future -this is also the difficulty of the medical field." Wu Zhiying Yingying. " express.

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