National Love Day: "Tooth Health", do not "sub -health"

We often hear such a sentence in life: toothache is not a disease, and it is really terrible. September 20, 2022 is the 34th "National Love Day". importance.

With the strengthening of the awareness of the oral hygiene and the increase in the awareness of the oral disease, everyone gradually realized that toothache is not only a disease, but also a bacterial disease. Caries and periodontal diseases (including gingivitis and periodontitis) are used as the two major oral diseases that affect human life and physical health, which will not only affect the functions of speaking, chewing, but also cause or exacerbate certain systemic diseases like crowns. Heart disease, diabetes, etc., the "culprit" that affects the quality of life.

As the "human window" mouth, is it good for its health? How can we evaluate its health?

Can the gums also be sub -healthy? Intersection

Have you only heard that everyone will "sub -health", gums? Will it also "sub -health"?

The scientific research team and its cooperative enterprises of the Single Cell Center of Qingdao Biological Energy and Process Research Institute of Chinese Academy of Sciences first proposed the concept of "gum -scholarship" for the first time. The experimental staff chose 40 patients with periodontitis and divided them into high hematopoietic groups and low bleeding groups. They arranged these patients to receive strict oral therapy for three weeks at the same time. The occurrence of experimental gingivitis caused it to have a significant and persistent state of gum bleeding to the 28th day. Later, the researchers carried out a series of dynamic multi -group research on the molecular mechanism of gingivitis on the process of gingivitis, covering the gingival plaque genome, metabolic group, and human saliva cytokine reactions.

Studies on 275 plaque samples of the gums found that 1-3 days after the suspension of oral prevention measures and oral hygiene behaviors, the flora structure, metabolic group and salivary cytokine factor of plaque For example, 11 kinds of salivary cytokines are activated, and benign bacteria in gingival bacteria florals have decreased rapidly, but pathogenic bacteria have risen sharply. This stage is the stage of the strongest interaction between the oral and microorganisms, and the periodontal tissue is in an asymptomatic prerequisite. Researchers call it a "gums of health" state.

Picture source: Qingdao Energy Institute Single Cell Center

Is your gums "aging"?

Although the "gingival sub -health" stage is temporarily and asymptomatic, it shows the characteristics of microbiological groups that are highly similar to periodontitis. The gingival bacteria flora changes regularly with the growth of human physiological age, and within 28 days of stopping brushing, the degree of aging of gingival bacteria is equivalent to the aging of 1 year when the gums are healthy, that is, it is less than not to the time. "Aging" for a month is almost one year old!

In other words, if the "gingival sub -health" state is not developed by restoration of oral cleaning nursing methods such as brushing brushing, its gingival bacteria flora float will exacerbate aging at a height of 10 times. Therefore, the "gums of health" state may be closely related to the aging of the gums. The long -term and effective oral care can take care of a healthy and young gingival flora, thereby avoiding or repairing the state of "gingival sub -health". It has extraordinary significance for delaying the aging of "gums" and glowing "gums".

"Flock indicators", a new method of evaluating the severity of oral diseases

Gingivitis is one of the most common oral diseases in the world. If it is not treated in time, gingivitis will evolve into irreversible periodontitis.

think! think! At once! pain!

The single -cell center center of the Qingdao Energy Institute cooperated with its cooperative enterprises and other companies. Through the structure and functional changes of the dental floral flora in the process of rehabilitation, development and rehabilitation of 50 adults, 15 that was significantly related to gingivitis was significantly related to 15 A bacterial genus, and proposes the "Microbial Index of Gingivitis; Mig), which is used to diagnose the severity of the oral infection. Based on MIG, the accuracy rate of judging the health of the gums reaches 95%, the accuracy of distinguishing the disease stage reaches 75%, and can predict the susceptibility of gingivitis. Mig is friendly to patients and does not rely on the subjective judgment of doctors. It provides new ideas for gingivitis monitoring and prevention and control. It also has important application value for evaluating and developing a new generation of oral care products.

Dental caries are often called "worm teeth", and the "insects" here are bacteria in plaque. Oral cavity is one of the human bacteria, and various bacteria live in lively. The plaque is firmly attached to the tooth surface, and the bacteria intake in the saliva to decompose and produce acid. These acids will destroy the teeth and then form caries. Obviously, the ultimate goal of dental bacteria is to push each tooth.

Qingdao Energy Institute of Energy Institute of Energy Institute of Energy and Sun Yat -sen University of Stomatology and other colleges, etc., collected 50 to 6 -year -old children's gingival plaque and salivary flora. Based on the analysis of the flora structure, the researchers proposed the "Microbial Indicators of Caries (MIC) that distinguishes related microorganisms related to age and disease status. The clinical symptoms have not yet predicted the onset of infant caries (ECC) with an accuracy of 81%. At the same time, the researchers proposed the concept of "ORAL MICROBIOTA AGE; OMA), and found that the OMA of healthy children is roughly consistent with their physiological age, but among children who have risky ECC risks and even children, their OMA has significantly deviated from Children's physiological age, so OMA can be used to warn and monitor children's dental caries. Picture source: Qingdao Energy Institute Single Cell Center

Play big data, open a new model of human micro -ecological health monitoring

The single-cell center team also released the first "microbiological group big data search engine-MSE (http://mse.single-cll.cn)" at home and abroad. Compared with the existing model-based machine learning methods, it should Methods no longer depend on the disease -related specific identifier microorganisms, but use the overall similarity of the genome of the fungus group to the genome of the fungus to measure the overall similarities of the existing bacterial element genome to achieve detection. This method achieves rapid and accurate disease diagnosis through flora detection, making it a reality to use the entire microbial group as an intelligent search and big data mining of the analysis unit.

MSE is just like our common search engine. Just enter the data of microbes and click "Enter". Large -scale, global microbial group comparison and search can be easily realized. Based on big data matching abnormalities, it can be judged whether it is healthy and greatly reduces the probability of "leakage"; and based on the best matching of the global situation to identify the type of disease, it can effectively reduce the "misdiagnosis". MSE can use the symbiotic flora in various parts of the human body to achieve individualized precision, health, precise care and precision nutrition, so that the big data of the microbiology group will help us not only "know it", but also "know why". Compared with conventional means, this method also has significant advantages in the adaptability and anti -interference ability under the influence of cross -research, cross -testing crowd, cross -sequential platform, and sample pollution. With the explosive growth of microbial sequencing data, the convenience and ductility of this method in practical applications will become more prominent.

Picture source: Qingdao Energy Institute Single Cell Center

Rush out of "sub -health" and win your healthy mouth

Gingivitis is a reversible lesion, but if it is not treated in time, it will develop into an irreversible periodontitis, causing the loss of soft and hard tissue and affecting people's lives and health. Oral hygiene must be protected. Do not regret it until the gums are hurt to cry.

Produced: Popular Science China

Author: Cui Xiaohui (Institute of Qingdao Biological Energy and Process of Chinese Academy of Sciences)

Producer: China Science Popularization Expo

references:

1. Shi Huang*, Tao He, Feng Yue, Xiujun Xu, Lijiang Wang, Pengfei Zhu, Fei Teng, Zheng Sun, Xiaohui Liu, Gongchao Jing, Xiaoquan Su, Lijian Jin, Jiquan Liu, Jian Xu*. Longitudinal Multi-omics And Microbiome Meta-Analysis Identify An ASYMPTOMATIC GINGINGIVAL State that Links Gingivitis, Periodontitis, AGING. Mbio, 2021, 12 (2): E03281-20. E03281-20.

2. Gongchao Jing#, Lu Liu#, Zengbin Wang, Yufeng Zhang, Qian Li, Chunxiao Gao, Meng Zhang, Min Li, Zhenkun Zhang, Xiaohan Liu, Jian Xu*, Xiaoquan Su*. Microbiome Search Engine 2: a platform for TAXONOMIC and Functional Search of Global Microbiomes on the Whole-Microbiome Level. Msystems, 2021, 6 (1): E00943-20.

Host & MicroBe, 2015, 18 (3): 296-306.4. Shi Huang#, Rui Li#, xiaowei Zeng, Tao He, Helen Zhao, Alice Chang, Cunpei Bo, Jie Chen, Fang yang, Rob Knight, Jiquan Liu,Catherine Davis, Jian xu*. Predictive Modeling of Gingivitis Severity and Susceptibility Via Oral Microbiota. The isme Journal, 2014, 8 (9): 1768-1780.

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