"Everyone shouts" uric acid, not as bad as you think

Many people did not know uric acid before, but they only knew that high uric acid could lead to gout. Often, after a physical examination, I found that when I was high in uric acid, I was "like the enemy", and then hurried to understand what the uric acid elevated represents.

High uric acid is often accompanied by physical problems such as gout, kidney disease, cardiovascular and cerebrovascular disease, and mention uric acid, which can be described as "everyone shouts".

But is uric acid a "bad guy" in the human body?

Actually not.

When talking about uric acid, purine must be talked first, we have purines in our body

Purine is the material basis of uric acid. The food we eat daily, the meat fish and egg milk of the animal -based source, and the vegetable and fruits of the plant -based source. In short, as long as there is a deoxyrum ribosacuucleic acid (DNA) and ribosaccharotic acid (RNA), the creatures contain purines.

Uric acid is synthesized by purine

Purine is divided into endogenous purine and exoggly purine. The purine produced by nucleic acid oxidation and decomposition accounts for about 80%, which is an endogenous purine; from external intake of foods containing purine, accounting for about 20%. Purine is absorbed by the gastrointestinal tract into the liver, and uric acid is processed in the liver.

Uric acid is usually transported in the blood, and it is mainly excreted through the kidneys and intestines. Most uric acid is in the form of uric acid in an acidic environment (pH <5.65), and our blood pH is about 7.40. In such a weak alkaline environment, uric acid mainly exists in the form of sodium uric acid.

Uric acid is not an absolute "waste"

· Uric acid enzyme is a "key" of the metabolic process

Our human, orangutan, and gibbon and other spiritual long animals lack an uric acid enzyme in the body compared to other mammals. The presence of uric acid enzymes can continue to oxidize uric acid into illarin.

The illegal capsule is much greater than the solubility of uric acid. It is a highly water -soluble substance that can easily excrete the kidneys from the body. Therefore, uric acid in the body is no longer the ultimate product of purine metabolism. Human and some other spiritual long animals are generally 240 ~ 360 μmol/L. Most mammals have a blood uric acid concentration of 30 ~ 120 μmol/L, mostly about 60 μmol/L.

However, unfortunately, in the process of evolution of spiritual long animals such as humans, orangutans, and gibbons, the genes that expressed uric acid enzymes have mutated, causing uric acid enzyme genes to lose work, and uric acid has become a purine metabolism of humans and minority longale animals. The final product.

· It is uric acid to help humans "stand up"

Everyone will definitely ask, since uric acid enzymes have such a special function, why do human ancestors choose to throw away "uric acid enzymes" during the long evolution and leave uric acid what it looks "bad" now?

In fact, uric acid has been considered a downright metabolic waste before. With the advancement of science and the continuous exploration of human beings, the current uric acid has successfully washed away the unnecessary charges of "downstream metabolic waste"!

Uric acid enzyme gene loss is the choice of human evolution. At present, the most credible explanation is that in ancient times, human ancestors lived in the subtropical forest, mainly based on fruits, and the salt obtained through food was very low. During this period, our ancestors experienced a long period of "low blood pressure" - Especially during the evolution of gradually transitioning to upright walking -at that time, the hypertension was like the hypertension of our modern people, and it was also a disease.

At this time, if the change brought by a gene mutation can improve the "hypotension" state, then this will become a "evolutionary choice", and mutations will become a superior mutation and retain.

Mutations of uric acid enzyme genes keep uric acid at a higher level. This changes in uric acid levels can help human ancestors maintain high blood pressure levels, help them maintain their body upright blood pressure in a low -salt environment, and promote their upright walking ability evolution. It can be said that it is the help of rising uric acid levels that humans have gradually "stood up."

Extraction of uric acid levels is conducive to human storage fat

Studies have shown that the global climate has gradually become cold in the later period of the new world, and fruit foods that human ancestors can get gradually decreased. At this time, the loss of uric acid enzymes has increased the level of uric acid in the body, promoting the fruit sugar obtained from the fruit into the liver into fat and stored it, which helps them through the cold food scarce period of the earth. This is particularly important in the ancient times of food scarce.

· Combat oxidation stress, remove oxygen free radicals

As a natural antioxidant, uric acid is similar to vitamin C. Both are water -soluble. The human body itself cannot synthesize vitamin C and must be intake through food. However, uric acid is mainly produced by the human body's own metabolism. It is the most water -soluble antioxidant in the human body. It is a member of the human body's antioxidant defense system. /3 free radicals.

Speaking of freedom, humans need to constantly oxidize the reaction during their lives. Entering oxygen into the human body, more than 95%of the oxidation food is converted into energy, and it is restored to water; the remaining less than 5%oxygen is restored to free radicals and active oxygen. Free radicals and active oxygen are necessary for the human body, and at the same time show the toxic effect. Many chronic diseases of humans are largely secondary to the oxidation damage of free radicals and active oxygen. Alzheimer's disease and so on.

Under normal circumstances, the human body can maintain the balance of free radical generating and removing, but as the age increases, the ability to remove the ability will not be cleared in time and effectively remove the free radicals and active oxygen generated by the normal metabolism of the body. At the same time, the human body contacts Harmful environmental factors and bad lifestyles will accelerate the generation of free radicals and active oxygen, which will exacerbate oxidative damage. Clinical studies have also found that in some chronic neurodegenerative diseases, blood uric acid also exists as antioxidants and brain protective substances. For example, the level of uric acid in patients with multiple sclerosis is lower than normal people and lower uric acid levels during disease activity; Parkinson's patients with low uric acid levels are low. Increasing uric acid levels can reduce the prevalence of Parkinson's disease, and delay cognitive functional damage. The emergence and progress; Alzheimer's disease also has similar clinical characteristics.

· Uric acid is a manifestation of "smart"

The level of high uric acid is related to high IQ. The chemical structure of uric acid and caffeine is similar. Some studies believe that uric acid can stimulate the stress reaction of the cerebral cortex, and it is speculated that uric acid oxidase genes are related to the evolution of ancient intelligence evolution. Related data shows that the incidence of gout among super -intelligent people is 1.8%, which is higher than the incidence of 1.5%of the general population in the same period and region. Physicist Newton has also suffered gout pain.

Newton portrait

The lower the uric acid, the better

Excessive levels of uric acid can indeed cause many diseases. However, we also have to treat some ideas of visual uric acid as "flood beasts" scientifically. The lower the uric acid is not as good as possible. For gout patients, the lower limit of the treatment target is that hemoglobin should not be less than 180 μmol/L; for ordinary people, blood uric acid is less than 120 μmol/L as hyperuric acid, which is a pathological state. Too low uric acid will increase the incidence of tumors, Alzheimer, and Parkinson's disease.

In addition, high uric acid plays a role in protecting bone metabolism, which can enhance bone mass and reduce the incidence of vertebral fractures. Therefore, in the treatment of gout or hyperuricemia, we should maintain uric acid in a reasonable and stable range to give play to its positive side of human health.

What is the lack of uric acid in the human body?

We know that uric acid is a double -edged sword, which is not good for the human body. If the human body lacks uric acid, the human body's blood pressure will be difficult to maintain, the ability to stimulate the antioxidant stress, and the level of IQ is decreased. At the same time, the incidence of tumors and nervous system will increase.

Taking the occurrence of acute cerebral infarction as an example, the body is in a stress state, the oxidation should be aggravated, causing further damage to the brain tissue. Damage, and protecting brain cells by protecting blood vessel endothelial functions, playing a neurological role. Therefore, in clinical discovery, when the occurrence of cerebral infarction, the degree of brain injury of patients with hyperuric acid levels should be lighter than those with low uric acid levels. After that, the recovery of nerve function will also be better, and it will be better in the recovery of nerve function. Patients with cerebral infarction are better than patients with low uric acid levels in all aspects.

Some studies have found that people with low levels of blood uric acid are prone to degenerate diseases of the nervous system, such as Alzheimer's disease and Parkinson disease. For people who merge these diseases or risk factors, the level of blood uric acid should not be too low. At the same time, some studies suggest that the level of blood uric acid and cardiovascular diseases are associated with a U -shaped correlation. Excessive blood uric acid levels and too low are not conducive to cardiovascular disease treatment. The lower serum uric acid level and higher cardiovascular disease mortality rate related.

In

Seeing this, do you understand whether you know, uric acid is not a bad guy, and the bad uric acid alloid is bad.

Wenyuan: "Terminal Pain", slightly deleted

Book Author: Li Changgui, Lu Zhaohui

Part of the map comes from the Internet

Copyright belongs to the original author

Edit: Zhang Runxin

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Source: Original Reading

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