Falling asleep at any time during the day and laughing will faint. The 23 -year -old girl checks the gene with "sleep disease"

Since junior high school, Jiang Jiang (a pseudonym) sleeps as soon as he class, and will faint when he laughs. The nightmares are constantly at night. It is not good for a year of school. Until the age of 23, she came to work in Shenzhen and checked at the neurology department of the General Hospital of Shenzhen University. According to reports, this is a rare disease with only 2-6 of 10,000 people. The peak age is 8-20 years old. It is the stage of children and adolescents that often cause long-term damage and trouble.

Go to bed in the daytime full of hallucinations at night, dare not laugh

At the age of 8, Jiang Jiang found that his eyes had umbelicitis, and he took a lot of medicines to treat diseases one after another. Later, he took hormones and immunosuppressants for a long time. Too concerned.

In the second day of the second year, Jiang Jiang had no consciously falling asleep in class, but because his grades were always among the best, the teacher did not have many tactics. In high school, there are more and more lessons during the daytime, and their homework gradually cannot keep up. The teacher thought many ways to let Jiang Jiang stand in class, let Jiang Jiang sit in the first row, and let the same table remind you from time to time. Jiang's sleepiness, she was sitting in the classroom, and she didn't even realize that she had fallen asleep.

During the day, torment at night, ginger and ginger are prone to hallucinations before going to bed. Various pictures are constantly appearing like a "walking lamp" in front of him. It is often awakened by nightmares in the middle of the night. She dared to fall asleep when she turned on the lamp in the bedroom. She had to drag the lamp into the bed. She woke up in the middle of the night and quickly turned on the light.

In addition, Jiang Jiang did not dare to laugh. When I was in junior high school, I went to watch a movie with my friends. I smiled too happily and fainted on the spot. Afterwards, I suddenly fainted several times. Jiang Jiang found that laughter was related to emotional excitement, and naturally he didn't dare to laugh.

Because of the pressure, Jiang Jiang discussed with his parents. After a year of high school, the local medical resources were limited. The doctor of the clinic said that only the eyes were inflamed. Take a needle on the eyeball. After a year, it still has not improved.

I have been taking medicine for many years, and I spent a lot of money at home. Jiang Jiang's only hope is to make money after growing up, and then go to the big city to cure the disease. Relying on this belief, Jiang Jiang was difficult to get into an ordinary university, and after graduation, he came to work in Shenzhen as expected. Once, she accidentally saw reports on sleeping medicine, so she hung up the clinic number of the Neurology Department of Shenzhen University General Hospital with a mentality of trying, and wanted the doctor to "check" her sleep.

The average sleep incubation period is 5.3 minutes, the shortest 0.8 minutes

After asking the symptoms and history, Huang Ruoran, deputy chief physician of the Department of Neurology, said that she is likely to have a seizure of sleeping and to identify with epilepsy. In order to find evidence, you need to conduct a multi -guided sleep monitoring + multiple sleeping incubation test.

Multi -guide sleep monitoring is a gold standard for evaluating disease -related diseases. It is a examination technology for continuous collection, recording and analyzing multiple sleep physiological parameters and pathological events in the sleep monitoring room.

姜姜遵医嘱，花一天时间做完检查，结果提示：五次小睡试验中，她有四次在8分钟以内睡着，平均睡眠潜伏期（从关灯到睡着的时间）只有2.8分钟，最短Once, she took only 0.8 minutes and fell asleep in 48 seconds.

Dr. Huang told her that this "second sleep" was a typical manifestation of seizure of sleep. Suddenly after laughing or emotional excitement is also one of the typical forms of seizures. The average time of normal people from lying on the bed to sleep is 10-30 minutes. If the sleeping time is too short, frequent sleep within eight minutes, eliminating the lack of sleep, you need to ask professionals to identify.

The doctor asked Jiang Jiang to check the blood routine, liver, kidney skills, and did not have obvious abnormalities. Let her do her lumbar spine puncture and extract the test center of the Beijing Seizure Disease Research Center for the cerebral spine. Results: Hulkoulin (HCRT 1) has declined significantly, and HLA-DQB1 has genetic mutations.

This related gene HLA-DQB1 is the key to sleep awakening regulation. Similar to sleep-awakening "switch", gene mutations are equivalent to switching a bit "failure". The switching "failure" means that not only does not wake up during the day, but also not sleep well at night, such as frequent awakening, dreams, and pre -bed hallucinations. The truth is big, and Jiang Jiang was diagnosed with "seizure sleep".

Huang Ruoran said that the disease may affect life. At present, the main treatment plan is that if there is a sudden attack, it can be controlled by medication; during the daytime, he can also find a way to reduce part, but the use of drugs is limited. The general method includes paying attention to improving night sleep, giving an appropriate environment, and avoiding excessive emotional excitement. In other words, if you find a way to "sleep well" at night, you can reduce the "second sleep" during the day.

In addition to the above symptomatic treatment, in recent years, with the improvement of the disease of the disease, it has also been found that adult patients have different characteristics and children with children. Patients in north and south have their own characteristics and may have different immune backgrounds related to influenza. These all suggest that the progress of scientific and technological progress in the future, the progress of immunotherapy may bring treatment to the treatment of seizures.

About 2-6 people of each 10,000 people occur.

According to research, the prevalence of seizure of sleep disease is about 2-6/100,000, and about 2-6 patients with sexual sleep disease per 10,000 people are 8-20 years old. The stage of children and adolescents. For this part of the patient, it is not because of being lazy, but because of being lazy, but because of the trouble of seizure. Typical symptoms of patients with seizures include excessive drowsiness during the day, sudden falls induced by emotional excitement, hallucinations before falling asleep, and sleeping paralysis. Other symptoms include abnormal weight gain, night sleep disorders, emotional disorders, and precocious puberty.

In 2021, Stanford University announced the latest results of the registration of sleeping in the United States. Although the first age of the disease was mostly adolescents, the average medical age was 26.4 years old, with an average diagnosis age of 30.1 years. 59%of patients have misdiagnosed once, and 29%of patients have experienced more than five diagnosis. Patients with illness on children are more obvious. The average period of first medical treatment to diagnosis has reached 4.5 years. This shows that sexual sleep diseases are still easy to be misdiagnosed and needed more attention and understanding.

The clinical standards of seizure of sleep diagnosis are mainly symptoms, multi -guided sleep monitoring, and multiple tests of lack of sleeping. This diagnosis is of great significance to occupations engaged in public relations safety (such as bus drivers and pilots). To classify this diagnosis, the cerebrospinal fluid is required to test the hypothalamic hydroma.

Shenzhen Evening News reporter Zhou Qian Correspondent Huang Ruolan Wang Suqi/Wen Ma Duo Ming/Picture

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