Industry, academic research teamed up to explore the biological mechanism behind aging

Deliven to establish an integrated R & D platform for aging intervention technology to explore the biological mechanism behind aging, to slow down the process of human aging through the corresponding intervention strategy, and it is expected to improve various health issues related to aging in the future. On August 17th, the China Science and Technology Copy Relief Molecular Network Anti -aging Laboratory was established. This was jointly established by the Saifu (China) and the Shenzhen Advanced Technology Research Institute of the Chinese Academy of Sciences.

The launching ceremony of the Chinese Science and Technology Retole Molecular Network Anti -aging Laboratory.

It is understood that through a strong union, the two parties will give full play to their respective resource advantages and develop and apply around the technical development and application of aging intervention NAD+(nicotinamide gonadotenune), screening of anti -aging substances, exploration of multi -target aging intervention, etc. The frontier technology research, technical platform establishment and talent training level have been extensive and in -depth cooperation, establishing long -term technology development platforms and good scientific research results transformation platforms. The cooperation between the two parties aims to achieve the integration and utilization of aging intervention research resources, and provide a broader application background for the clinical progress of aging intervention, in order to become a key promoter for the development of life science research and contribute to healthy aging.

NAD+is a necessary coenzyme in the metabolic reactions of many human body. At present, the academic community believes that NAD+participating in thousands of physiological reactions in the human body is closely related to many aging -related diseases. However, it is difficult to directly supplement NAD+to be absorbed by the human body, and the transformation efficiency is low. Researchers have turned to "curve to save the country" to study the precursor material and other forms of NAD+. Among them, NMN (nicotinamide monocyte nucleotide) of NAD+was confirmed by Harvard professor David Simch Lai, which can improve the NAD+level in the body. Therefore Questions about the effect of NMN.

NAD+Qualified protein probe detection technology, the first person in the invention of the invention of the Chinese Academy of Sciences, the research research research center of the Shenzhen Advanced Academy of the Chinese Academy of Sciences. For its different degrees of response, some people will respond to heterogeneity or not responding. This exists objectively, but it cannot completely deny its effect. " Happening.

The chief scientist and blog director of the China Science and Technology Copy Relief Laboratory Laboratory were delivered in Qiu Liyang.

This result was also confirmed in many clinical studies of NMN. In 2021, a clinical trial result published in the United States in "Science" showed that the impact of NMN on special groups was significant. Test papers also show that some healthy volunteers have heterogeneity after taking NMN oral NMN, and there are people with obvious clinical metabolic effects and weak responses.

In order to further explore the reasons, in the key research and development plan of the Ministry of Science and Technology, in the NMN clinical trials of Saili Fu participated in and carried out by Guangzhou Sports University, scientific researchers conducted in -depth research on supplementing NMNs from non -response people. Some people do not respond after taking NMN. And this non -response phenomenon is closely related to the high expression of a CD38 protein.

CD38 is a protein that is closely related to the immune process. The CD38 on the cell surface will degrade NAD, NMN, and NR and other nucleosides to form NAD+supplementary barriers. After the NMN enters the cells into NAD+, the CD38 will be degraded by the interior of the cell. Some CD38 protein expression in the human body is particularly high, which makes it impossible to improve the level of NAD+in the body even if taking high -dose NMN. Or invalid. The key to resolving is to inhibit the high expression of CD38.

According to Qiu Liyang, according to calculation analysis, it is different from that of NADH, NRH, NMNH and other hydrogen molecules such as NMN pathways that are less affected by CD38, which is a potential and more efficient NAD+supplement method. However, Hydrogenation such as NADH, NRH, NMNH, etc. has more easily deteriorated characteristics, it is difficult to control and difficulty in long -term stability. Therefore, in the transformation application, researchers have always been a difficult point that researchers need to overcome.

At present, Saili Fu (China) has overcome the difficulty of stabilizing NADH for a long time. It has made Lihuangyuan (Saili Fu NADH) that can still ensure stability under storage conditions for up to 3 years, and obtained a number of items and obtained a number of items. Patent. Based on this, the joint laboratory will more deepen how to make more advanced, efficient and safe use of NAD+hydrogenation precursors such as NRH and NMNH.

Determine whether the CD38 level in the body is highly expressed, and understand whether the NMN you supplemented has really achieved the due effect. The test of NAD+levels has become an important means. The China Science and Technology Said Resistance Joint Laboratory plans to use "NAD+Detection" as a technical breakthrough, conduct "super clinical trials", and apply the world's first NAD+probe high -throughput detection technology to deeper aging research. This NAD+probe detection technology can quickly and conveniently detect the content of NAD+in the human "aging indicator", and a large number of samples can be detected at one time.

Prior to this, aging could not be measured, so it was difficult to effectively interfere and manage it, and NAD+detection made aging quantification possible. "NAD+Testing Super Clinical Test" will give more people the opportunity to understand the level of NAD+in their body, better evaluate the degree of aging, and make personal exclusive anti -aging portraits more and more accurate. At the same time, it can also be found that NMN does not respond to the crowd through NAD+detection, discover customized NAD+supplementary solutions. Through more effective NAD+supplementary solutions, combined with the corresponding lifestyle, it can better avoid or reduce the occurrence of certain diseases. It is reported that Saili Fu (China) is a high -tech enterprise dedicated to AI multi -target anti -aging research and industrialization. It has a strong scientific research team and R & D application platform, which can continuously transform cutting -edge core technologies into healthy products. NMN anti -aging discoverers Wei Simclai, a professor of cell genetics at the University of Harvard University, used the generation of raw materials for Saili to conduct scientific experiments, and published NMN reversing blood vessel aging in 2018 at the top academic journal "Cell" in 2018; Repeatedly participated in the large -scale NMN human clinical trials carried out by Guangzhou Sports University. The project belongs to the key special project in the key research and development plan of the Ministry of Science and Technology of China; Provides NMN raw materials. Saili Fu has established a systemized aging intervention research process from an aging mechanism, aging evaluation system, to the screening of anti -aging core substances, and precise nutritional intervention solutions.

After more than 10 years of development of the Shenzhen Academy of Sciences, the Shenzhen Advanced Academy of Sciences has applied for a total of 8,748 patents, 3587 authorized patents, published 10026 papers, 30%of high education returnees, and in the fields of biomedical engineering, synthetic biology, biomedicine and other fields, Many scientific research results with originality and significance have been established. It has established a collaborative innovation ecosystem integrating scientific research, education, industry, and capital. It is a model of China's new research institutions.

In the future, the China Science and Technology Saitatta Anti -aging Laboratory will quantify aging through big data and comprehensively evaluate the aging of individuals to help humans realize more accurate intervention on aging, improve the status quo of population aging from the social level, improve the quality of life of everyone Essence

Scientists of the China Science and Technology Saitor Revitalization Laboratory Laboratory stated that the "sub -cell space -time distribution representation and regulation drug screening research" project is undergoing "aging -related metabolites" projects. This is an important step for anti -aging research.

(The photo is provided by the China Science and Technology Saitatta Resistance Anti -aging Laboratory)

Source: Science and Technology Daily

- END -