The first research on the genome of Huanghua Artemisia Prefecture for the Genome

Content source: China Traditional Chinese Medicine News Correspondent: Huo Wenwei

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Recently, the cover article of the top international botanical journal "Molecular Plants" published a research paper entitled "Relative to ADS Gene Expansion and Artemisinin Contents" entitled "Emart Artemisia Prefecture -chromatography Genomic Genome". The application of the selection of new varieties of Artemisia has achieved outstanding results.

Artemisinin is a first -line antimalarial drug recommended by the World Health Organization. Since its launch in 1972, it has saved the lives of millions of people in the world, especially developing countries, and Artemisia annua is the base plant of artemisinin. The study was jointly cooperated by the Chinese Academy of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, the Artemisin Seminar Research Center of the Chinese Academy of Traditional Chinese Medicine, and the Chengdu University of Traditional Chinese Medicine. Researchers used Pacbio Hifi, Bionano Optical Map, HI-C A variety of sequencing technologies effectively fit the scale differences between overlapping groups and chromosomes, and successfully obtained the foundation of maternal germ bodies of Artemisia Artemisia Prefecture, laying a foundation for the analysis of the mechanism of biological synthesis and control of artemisinin.

The genome obtained by the study is the first high -quality genome of chromosomal levels of mitochia chromosomal. Through the high -quality genome of Huanghua Artemisia annua, researchers have found that the number of key -limited enzymes auroenherase encoded gene ADS is highly related to the content of artemisinin content. Effective.

The relevant person in charge of Chengdu University of Traditional Chinese Medicine stated that this study is of great significance to ensure the supply of the incidence of malaria in 2030 by the presence of WHO's incidence and mortality by at least 90%of the mortality rate and mortality by the WHO in 2030. Essence Liao Baosheng and Xu Jiang of the Institute of Traditional Chinese Medicine of the Chinese Academy of Traditional Chinese Medicine are the first author and the first communication authors of the paper, Guo Shuai, Chengdu University of Traditional Chinese Medicine, as the first author of the dissertation, and the chief researcher of the Chinese Academy of Traditional Chinese Medicine, Chen Shilin, the author of the paper. The journal also published an evaluation article entitled "50th Anniversary of the Research of Artemisinin: From the Found of Artemisinin to the Establishment of Chromosome Genome".

Edit: Wang Di

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