Change and functional differences in oxopopharynal microorganisms are related to the severity of new crown pneumonia

From August 26th to 28th, 2022, under the auspices of Professor Li Lanjuan, an academician of the Chinese Academy of Engineering, the Micro Ecological Special Committee of the Chinese Prevention Medicine Association held the National Micro Ecological Conference Academician Forum and the China Infection Sympathetic Conference in Jinan, Shandong. Professor Ma Shengli, the deputy secretary of the Party Committee of Heilongjiang Provincial Hospital, Deputy Dean of the Party Committee of Heilongjiang Provincial Hospital, Deputy Dean of the Party Committee of Heilongjiang Provincial Hospital, and Director Ma Shengli entitled "Patients with New Crown Pneumonia Special reports of the macro -based group and metabolic group studies of microorganisms ". This study is based on the principle of micro -ecological science as the breakthrough, and the permanent nasopharyngeal flora and metabolic products are detected and analyzed by the permanent flora and metabolites, which reveals the mystery of the nasal and pharyngeal accent resident flora and the new coronary virus infection. Experts and scholars at the meeting.

The content of this report stems from the beginning of the new crown epidemic at the end of 2019. Professor Ma Shengli and her team undertaken a "major emergency project of the new crown epidemic" of the Heilongjiang Provincial Government. Related Research on the Planting of New Crown Virus ". Relying on the "Heilongjiang Provincial Hospital affiliated to Harbin Institute of Technology" and "Heilongjiang Provincial Oral Micro Ecological Technology Innovation Platform", the research on new crowns was quickly carried out. The research plan was approved by the Provincial Medical Ethics Commission and the Provincial Biological Safety Committee, and passed the registration of national medical research registration and information system registration.

In response to many problems such as the inherent connection of the new coronal virus infection and the micro -ecological and its nucleic acid testing, the team focuses on the "micro ecological research of the new crown virus infection", "the construction of the hospital's nucleic acid testing and risk prevention and control closed -loop system under the new normal" and " The "three major sections" of the "three major sections" such as portable fast new coronal virus nucleic acid detector "research and development" and other foundations, and innovated in -depth exploration, successfully developed the first portable fast new crown virus nucleic acid detector at home and abroad. The epidemic prevention and control saves human resources and costs. The invention has obtained a national invention patent, and the relevant results are published in the "Nature" subsidy.

In late July this year, the results of the "Related Research on the Relationship between the Changes in the Mosaic and Neo -Crown Virus infection of the Popular Foundation of the Oral Nasalt and Nasalt" passed the acceptance of the topic organized by the Heilongjiang Provincial Department of Science and Technology, and obtained the "excellent" good in the acceptance and acceptance. score. The results of its important research include: the characteristics of the oral and pharynx group of the new crown pneumonia is the consumption of pathogens such as Weirong bacteria, giant ball -type bacteria, and pseudolybacterium, and the genus of Pseudoma, Rose bacteria, and rin. Among the 10 representative species of pneumonia patients, 8 species have an increase in the number of oral microbial groups in new crown pneumonia patients, which confirmed that the oral cavity may be the source of pathogens infected with the lungs.

At the same time, the scientific research team discovered that Wei Rong bacteria belong to the most prominent biomarker in the new crown pneumonia case group, especially Xiao Weirong bacteria are highly enriched in the oral pharyngeal patients of new crown pneumonia. There are too many expressions, which indicates that the oral cavity is a natural storage library of the pathogen, which can induce merging infection in the lungs of new crown pneumonia; and the severity of the new coronary pneumonia is positively related to the systemic inflammation symbol and age; Craber, no, no, no The proportion of dysentery and Sravius ​​is increased, which is related to the severity of the disease and the elevation of the increase of the inflammatory signs of the whole body. It is reminded that the changes of these oral and pharynx microorganisms may affect the severity of the new crown pneumonia by affecting the inflammatory reactions; The patient's oxopophageal microbiology group also shows significant enrichment in amino acid metabolism, heterogeneous biodegradation and metabolism.

The microorganisms in the throat of the new coronary pneumonia and the influenza patients have less membrane transshipment potential and poor cell motion in cells in ions, lipids, alcohols, peptides, proteins, and carbohydrates; Medicine genes are significantly rich in critical patients. The changes and functional differences of the Ma Shengli research team found that the change and functional differences of the oral pharyngeal group are related to the severity of the new crown pneumonia; the results of the analysis of metabolic groups show that in the positive and negative ion mode Separation; found 35 new crowned metabolites, and is mainly divided into fatty acids, amino acids, nucleic acids, organic acids, phenols and derivatives, amine, benzene, and its derivatives, hormones and mounts, alcohol lipids, etc. ; Pathfields found that the metabolic pathway of the significant changes in new crown pneumonia is tyrosine -related metabolic pathways.

Through the research results of the above -mentioned "Study and Metabolic Group Study of the Macrocellian Group of Patients with New Crown Pneumonia", the research team obtained a flora and metabolites that are specially related to the new coronary virus or influenza virus infection. Based on this, Professor Ma Shengli proposed the importance of oral micro ecological balance to prevent and control of the infection of the new coronary virus: first, these results are of great significance to the clinical diagnosis and treatment of new crown pneumonia; Microbial group monitoring sub -health status has important advantages and characteristics; the screening and appraisal of certain oral alienal flora in the state of clinical diseases can early warning the lung microchaser disorders or potential pathogens to invade the lungs, thereby guiding clinical medication. At the same time, related research results can be used for health guidance, maintaining good daily habits, eating habits, oral and physical health habits, etc., which helps to achieve self -maintenance and establishment of oral micro -ecological balance, reduce new crown virus and other virus infections and sensibility. , Block the "disease from the mouth", reduce the chance of lung infection, and avoid sub -health.

In addition, Professor Ma Shengli also reported the results of the research team's research on nucleic acid detection. The project team optimized the entire process of the P2 laboratory through a chain -type P2 laboratory to improve the efficiency of the hospital nucleic acid detection and ensure the timely rescue of patients with critical condition; Professor Ma led " The Fire Eye "Mobile Laboratory came out of the Rocket Village in Kui County and the Forestry Bureau of Xinglong Town, Bayan County to resist and gain experience. In the research and development process of portable fast detectors, Professor Ma many times organized team members to complete the detection and quantitative detection of fast -moving acidic acid based on micro -flow control technology; research and judgment and difference in the experimental results from the perspective of micro -ecological professional; Portable system improvement, finding risk points, and repeated emphasis on biological safety design have made useful explorations. At present, the scientific research team publishes 1 SCI article in the study of the above -mentioned projects in the study of the new crown infection and the micro -ecological correlation of mouth, nose and pharyngeal cavity (influencing factor 18.187), which provides preventive measures and constructive opinions for the new crown prevention and control; based on the above research , Develop the first portable fast new coronary virus nucleic acid detector at home and abroad, apply for 5 national invention patents, and three utility model patents have been authorized. At the same time, subject research has been successfully shortlisted for the finals of the "Future Star" achievement transformation project finals; and in the new normal The improvement of nucleic acid detection capacity and risk prevention and control closed -loop system in the hospital also achieved the results of the construction of the risk prevention and control closed -loop system. These research results were reported and reproduced by many authoritative media in China, and they have achieved good social benefits. Not long ago, Professor Ma Shengli was also awarded by the Ministry of Science and Technology of the Ministry of Science and Technology.

- END -