What should Agmeratine who can treat depression and improve sleep, what should I pay attention to when used?

Hua Zi's recent sleep was not very good, so he joked with his colleagues, saying that he had a bad mood recently. He might have suffered from depression and caused insomnia. But a colleague told Huazi seriously that he could try Agmeratine.

Hua Zi said that he was joking with depression, but friends who had had depression asked Huazi, what should I do if I have insomnia at the same time? And colleagues said that Agmeratine can just solve this problem. This is a new type of antidepressant drug that can improve sleep while treating depression.

1. Why can't I feel happy?

Depression is a common mental illness, and severe cases can cause patients to self -harm and commit suicide. The prevalence of depression is about 11%of the crowd, but only 3%of people can be treated. When depression, people will not feel happy. Food, beauty, and even the stimulus of money and beauty cannot make the depression people interested.

Many people think that depression is a mental level, but in fact, depression also has physiological changes, mainly the result of hormone secretion disorders in the brain.

There are two types of hormones: norepinephrine (NE) and dopamine (DA) in the human brain, which can make people feel excited and happy; there is also a hormone 5-hydroxyline (5-HT). The role of 5-HT is very complicated and can be combined with a variety of receptors to play a different role. When combined with the middle neurons 5-HT2C receptor, it will play a negative role in NE and DA to help us control emotions and prevent the brain from overloading due to excessive excitement.

However, the middle neuron is extremely active. When the 5HT2C receptor is combined with a large amount of 5-HT, it will block the information transmitted by "happy hormones" such as NE and DA, and our brain cannot feel the feeling of "happiness".

Second, the role of Agmeratine

Agmeratine can be combined with an intermediate neurons 5-HT2C receptor, thereby inhibiting the combination of receptors and 5-HT, which can relieve the negative regulation of NE and DA, so that the information of "happy hormone" can be passed normally. We The loss of happiness can be re -felt.

The structure of Agmeraine is similar to the structure of the human body, which can directly activate melatonin receptor (MT1 receptor, MT2 receptor). Melatonin is a hormone generated and released at night. It is responsible for maintaining the rhythm of the human body day and night, which can improve the sleep cycle and maintain the time and quality of sleep. Agmeratine can play the same role as melatonin, which can improve sleep.

3. What do you need to pay attention to when taking medicine

The traditional treatment of depression is usually a combination of antidepressant drugs and sedative hypnotic pills. It has a long time in suppressing the central nervous nervous system and has a drowsiness effect during the day. And Agmeratine regulates sleep through the melatonin system, which has a small impact on the mental state of the day, and it may be small that produce drug dependence.

However, Agmeratine is only effective for mild and moderate insomnia, and has poor effects on severe insomnia or long -term insomnia. Those with severe symptoms of insomnia are likely not only lack of melatonin, but also other diseases and spiritual factors. Using Agmeraine may have no effect.

Agmeratine has a significant effect on the liver function, so the liver function needs to be checked in the 3rd, 6th, weeks, 12th, and 24th weeks of medication. medicine. During the medication, we should also pay close attention to the symptoms of liver injury such as fatigue, deepening urine, and yellowing of the skin or eyes.

Agmeratine may cause adverse reactions such as anxiety, headache, dizziness, nausea, back pain, and digestive tract reactions, but the symptoms are usually mild.

Agmeratine is mainly metabolized through liver medicine enzyme CYP1A2. It is necessary to avoid combined use with CYP1A2 strong inhibitors (fluorogshaming and ciprobutsstars). Do not drink alcohol during the medication.

To sum up, Agmeratine has two effects: antidepressant and improvement of sleep. The adverse reactions are small, but the intensity of the medicinal effect is also weak. There is also an obvious disadvantage that the price of drugs is more expensive. People with depression should use drugs under the guidance of a doctor, and at the same time maintain a balanced diet, exercise regularly, establish a good interpersonal relationship, and build a strong psychological defense for themselves to stay away from depression. If you have doubts about medication, please consult a doctor or pharmacist. I am a pharmacist, and welcome to follow me and share more health knowledge.

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