"Eat while it is hot" caused by the esophageal squamous carcinoma molecular mechanism to be revealed

Recently, the British Cancer Magazine and the British Cancer Research Center jointly published the research results of Li Zhiyuan's team of Li Zhiyuan, a researcher at the Guangzhou Institute of Biomedicine and Health of the Chinese Academy of Sciences. They not only revealed the important role of the instantaneous receptor potential ionic channel vanilla samiyamin 2 (TRPV2) channel in the development of esophageal squamous carcinoma, but also put forward a new direction for the prevention and treatment of esophageal squamous carcinoma.

The first discovery of the study was found that the active TRPV2 repeated heating or excitement can activate HSP70/27 and PI3K/AKT/MTOR signaling channels. In vitro experiments Rather and diffusion.

The onset and progress of the known esophageal squamous species carcinoma are related to multi -gene abnormalities, and the external environmental factors, especially high -temperature diets, are considered one of the main risk factors that cause esophageal squamous carcinoma. In fact, high -heat stimulation has been listed as one of the causes of esophageal squamous carcinoma by the International Cancer Research Agency.

To this end, based on the research of the instantaneous receptor potential ion channel (TRP) for many years, the Li Zhiyuan team first detected the expression and function of thermistor TRPV in human esophageal squamous epithelial cells. Compared with non -tumor tissue, ESCC cells and The TRPV2 expression in clinical ESCC samples has been significantly up, and calcium imaging experiments have confirmed that its functional activities have been increased accordingly.

Further studies have found that after activating the temperature (54 ° C) of the TRPV2 channel (54 ° C), ESCC cells have been brief and frequent thermal stimulus, which can significantly enhance the behavior of vicious cells such as the proliferation, invasion, and vascular production of ESCC cells in vitro experiments. Experiments can significantly promote tumor metastasis of nude mice subcutaneous tumor and tail vein injection, indicating that over -expressed TRPV2 can turn non -tumor cells to tumor.

It is worth noting that the research found that the activation temperature of the TRPV2 channel is 54 ° C, which is lower than the diet temperature of many people, and is far lower than the high -temperature dietary risk temperature (65 ° C) recommended by the International Cancer Research Agency. Therefore, the study put forward a new direction for the prevention and treatment of esophageal squamous carcinoma.

Related thesis information: https://doi.org/10.1038/s41416-022-01896-2

(Originally on the 1st edition of the 1st edition of the China Science News 2022-08-10)

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