Breast milk hypogonic glycogen: Domestic infant powder is expected to reach

Source: China Food News

In recent years, breast milk hypotonal (HMOS) has not only become a hot topic in the field of nutrition and health research at home and abroad, but also has been widely used as an innovative functional raw material in foreign infant powder products. At the 15th National Nutrition Science Conference, the Breast milk hypotonal glyc glucose regulations and scientific application sub -forums were held during the 15th National Nutrition Science Conference. People in the industry shared the research progress of HMOS in global breast milk and the scientific research progress of HMOS in infantile powder.

HMOS protects the newborn intestinal barrier

Zhang Yumei, a professor at the School of Public Health at Peking University, said that HMOS is generally carbohydrates connected by 3-10 monosaccharides through the glycoside chain. It is a complex hybrid hybrid glycogen in human breast milk. The infant's intestine does not contain a hydrolyzed HMOS enzyme system, so HMOS does not directly exert nutritional function and cannot provide energy. There are many types of HMOS. At present, there are more than 200 HMOS that has been confirmed in human milk. N-four sugar (LNT), 3′-salivary lactose (3′-SL) and 6′-salivary lactose (6′-SL) are the main research objects. Among them, neutral hypolon sugar accounts for 80%-85%, such as 2′-FL, LNT, etc.; Acid hypocrustes accounted for 15%-20%, including 3′-SL, 6′-SL, etc. Zhang Yumei said that the proportion of secretion types in different regions and different human beings is different.

Guo Huiyuan, a professor at the Department of Nutrition and Health of China Agricultural University, said that HMOS can promote probiotic growth, inhibit harmful bacteria adhesion, protect intestinal barriers, regulate intestinal cell proliferation and differentiation, regulate the body's immunity, and promote cognitive functional development. Guo Huiyuan explained that the functions of HMOS in different structures are different. The ability to use hybridobacteria has a strain specificity for HMOS. The genes of the strain determine their metabolic capabilities to HMOS. , Choose each other.

Wang Xin, a researcher at the Zhejiang Academy of Agricultural Sciences, said that childbirth and feeding methods seriously affect the early formation of neonatal flora. After the birth of infants, some studies have found that the newborn intestinal flora feeding in the first 3 days was higher The utilization of lactose and 2′-fl. Newborn early fungus planting has a priority effect. The establishment of early flora in the early stage is a random process. Due to the HMOS content and the selectivity of the composition, the early fungus structure affects the development of the intestinal mucosa and the development of the immune system. Essence

More and more regulatory agencies are approved to include HMOS into the formula

At present, HMOS products are mainly added in the world. Dr. Pan Yu, Director of Scientific Affairs of Disman (China) Co., Ltd., said that breast milk is the best food for infants and the gold standard for infant powder. Add optional ingredients within the allowable scope of regulations. The gap between breastfeeding. On the basis of scientific research at this stage, HMOS is one of the biggest differences between breast milk and infant powder. Pan Yu explained that HMOS is the third largest solid component with high content of human breast milk, second only to lactose and fat, and has important physiological functions. HMOS is different from the traditional preparations added to the baby powder in the structure. Based on clinical and clinical data, HMOS can provide babies with various health benefits. The intestinal microbial group is close to the baby's feeding baby, which is related to the baby's intestinal development and the health of the body, affecting system immunity and reducing certain infections. The United States and Europe are the earliest commercialization of HMOS. The 2′-FL has obtained the US-Europe market regulatory license in 2014. Subsequently, more and more regulatory agencies around the world have approved it into the formula.

Zhang Yumei also said that HMOS is largely different from the structure unit and species in terms of hybrid galactose (GOS) and hybrid fructose (FOS) in infant powder. Since 2005, the research team has collected more than 50 breast milk samples from Lishui, Hebei, and started to conduct research on the north -south breastfeeding queue in 2018. The team's breast milk component research in 17 years has spread throughout the country, including international multi -center research. Studies have found that not only the low polysaccharides and content in breast milk vary from person to person, but also the composition and content of Chinese breast milk hypotonal, and the content is special. It should formulate the application suggestions of HMOS in Chinese baby food in accordance with the actual situation of breast milk in China.

Professor Wang Shuo, deputy dean of the Public Health and Health Research Institute of Nankai University, said that the research team measured the contents of 6 HMOS such as 2′-FL, 3′-SL, including 2′-FL, 3′-SL. The mature milk of Chinese mothers has different content among regions. The changes of the contents of the six HMOS content in Guangzhou in Guangzhou can be discovered that the general presence of 2′-FL in breast milk is high. Based on its content, breast milk can be divided into low 2′-FL content group and high 2 high 2. ′ -FL content group, the proportion of the low content in which the low content group is 21%(can also be considered a non-secretion type), and the high content group accounts for about 79%of the breasts. FL may have high tolerance. At present, the scope and limited edition of the 2′-FL in the formula of infant recipes have been approved in the United States, the European Union, and Australia and other countries and regions. Zhang Jianbo, a researcher at the National Food Safety Risk Evaluation Center, said that HMOS is a new variety of food nutritional enhanced agents for genetically modified microbial sources. The National Food Safety Risk Evaluation Center has twice issued soliciting opinions on 2′-FL in 2016 and 2021, and and and and and also, and comments From April to May this year, the comments were disclosed again. The scope of the solicitation of this comments includes in addition to the modulation of milk powder, it also includes infant formula foods and special medical use formula foods. Its recommended amount is 0.7-2.4 grams/liter.

(Responsible editor: Yang Xiaojing)

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