"Taishan Award" winner Wang Yongjun: rewrite the guidelines for global cerebrovascular disease and make a Chinese voice

On August 13, the 3rd "Taishan Award" awards will be held in Shanghai. The annual "Clinical Research Award" was awarded Wang Yongjun, dean of Beijing Tiantan Hospital affiliated to the Capital Medical University. Twenty years ago, he walked into the dream described by the old dean with blood; 20 years later, he established a milestone of the precision medicine of cerebrovascular disease in the world, taking the Temple of Heaven Hospital to the center of the world stage.

(Detailed agenda attached to the "Taishan Award" at the end of the article)

Written article | Yang Chen

Source | "Medical Community" public account

On October 28, 2021, the "New England Medical Magazine" (NEJM) published the CHANCE-2 research results of Professor Wang Baojun, the dean of Beijing Tiantan Hospital of the Capital Medical University, and the deputy director of the National Neurological Disease Clinical Medicine Research Center. For patients with light ischemic stroke and short -term brain ischemia (TIA) and carrying genes such as CYP2C19, such as Garrilo and aspirin to prevent recurrence of stroke than clopidogrelin, the former is better than the latter than the latter. During 90 days, the recurrence rate of strokes decreased by 23%.

The Chance-2 Studies are the first three-phase clinical trials of the global cerebrovascular precision medicine, which has a milestone significance. It took only 9 days from the submission to the NEJM editorial department to publish it: 5 days from the submission to the delivery of the foreign trial, and the three experts who tried it for only 4 days, and the journals were seen in 3 months. On the day of the journal, the results of the CHANCE-2 research reported at the World Stroke Conference (WSC) and shined. It became the most heavier study at the meeting. The only studies published in the top of Nejm).

Therefore, on the occasion of the 3rd "Medical Circle Value Medical Taishan Award", Professor Wang Yongjun, head of the study of CHANCE-2 research, won the "2022 Clinical Research Award". In this regard, the "medical community" also conducted in -depth dialogue with Professor Wang and talked about the story behind this.

Everyone picks firewood and overcome all difficulties,

Establish a milestone in the global cerebrovascular precision medicine

"The" Taishan Award "means that it is more important than Taishan. It must be very happy to give me such a heavy award." Professor Wang said, "I understand that value medical treatment is to achieve the best clinical effect at the lowest cost. That is to say, the ending we are pursuing is not to see how much money the patient spent, but to see if this money is valuable, can it give the patient the best ending and the best medical quality. CHANCE-2 Studies can be said to be said to be said to be it. Designed according to the concept of value medical care. "

The previous CHANCE research was published in 2013, breaking the internationally unable to use double anti -platelets internationally, and changed the world guide, but which patients benefited more? Therefore, the CHANCE-2 studied clinical trials to the world's first pharmaceutical genome in the field of cerebrovascular disease. This is also a real precision medicine test, and it is also a test that transforms patients from the past primary evidence -based medicine to precision medicine, so that we can give the correct individualized treatment in the correct way in the right time in the right time in the right time. As a result, China and the International Guide will be updated.

Therefore, in the field of cerebrovascular disease, this is a milestone research, which means that in the treatment of cerebrovascular disease, the application of precision medicine has data support and support of evidence -based medicine.

Of course, the research process is complicated. "It took three or four years to prepare the process, because many technologies could not break through. The biggest technology that could not break through is fast genetic testing." Professor Wang told us, "Because the patient is lying in the emergency department, my gene must be one hour for an hour Get the result! This has been spent for nearly two years. "For the CHANCE-2 research, the National Nervous System Disease Clinical Medicine Research Center has developed rapid gene detection technology, which is almost 100%accurate. Next to the bed. "Now the United States, Germany, and Australia are seeking our help and helping them to do new clinical trials." Professor Wang said, "Tiantan Hospital has a new emergency department this year, and there are fast genetic testing next to the bed. In this way, the patient is here. You can predict whether the administration is used in advance, will there be adverse reactions, so that patients choose a medical method that is more valuable 'for him. "

Breaking through the barriers of technology, solving shortage of funds, supply of drugs, and doing quality control in more than 200 hospitals across the country are the other major problems facing Professor Wang's team.

"Here I would like to thank Shenzhen Xinlitai Pharmaceutical Co., Ltd. and Chongqing Jingyin Biotechnology Co., Ltd. for free for all the drugs and inspection equipment required for the test, which is free." Professor Wang said, " In addition, 202 hospitals across the country are the most worthy of thanks. We can't give so much funding. Most of the opportunities have no signature. Most hospitals can only be behind -the -scenes heroes. "

During the experiment, the patients were used in less than one year. Since then, there are special project management teams to follow up, and the quality control quality of three levels of quality control. Professor Wang introduced: "The first -level quality control is our data team to do a good job of data logic; the secondary quality control is to rely on the project manager to take the entire project management team to 202 hospitals, one family to trace the source; the third -level quality control is external Third -party monitoring. "With the high enthusiasm and the unremitting efforts of various parties, at the time of the study, more than 6,000 subjects had a release rate of less than 1%. "There are countless touching stories during the experiment, which inside the Chinese neuroscience clinicians' dedication and selfless dedication to clinical research." Professor Wang recalled, "Thanks to these very dedicated doctors."

On August 3, 2022, the CHANCE-3 research will start, hoping that these three studies can establish three milestones for the global cerebrovascular disease field, so that China can be in the world's leading position in this field.

Because "the brain is good" into the neurology department,

Due to a pass from the Ocean phone, I came to Tiantan Hospital

After dozens of years of medicine from the neurology department, Professor Wang said with a smile: "In the beginning, the neurology department was not selected by me, and I did n’t study medicine. I went to college at the age of 15. The first volunteer was chemistry. Because it was not enough, it was not enough. The first volunteer admission score entered the Second Volunteer Medical College. "After graduation, he was only 20 years old. Professor Wang did not know where his volunteer was. When he rotated in the hospital, when he arrived at the Department of Neurology, the director of the Department of Neurology, "Your kid's brain is so good, why not do the neurology department" leaving Professor Wang in the neurology department. The director must not think that his own sentence changed the life of the young man, and even leveraged the pattern of China, and even the global cerebrovascular disease.

"I just" get married first and then fall in love ". After entering the neurology department, I found that I would not have a lot of things, and the anatomy of the nerve was not proficient." Professor Wang said, "I used it for a year to make an anatomy and hand -painted all the anatomical maps. Once again. "Under the encouragement of the director, Professor Wang's anatomy was printed into a book. This is the first book from Professor Wang. It is still in use. "After that, I slowly have fun, and I like it (neurology)."

The director also encouraged Professor Wang to engage in scientific research, such as initially encouraged Professor Wang to use electron microscope to find the cause of the patient's cause. "So I was the first person to use electronic microscopes in that hospital. My first paper was an electronic microscope -related papers." Professor Wang recalled, "It is important to see that young people encounter a teacher who guides you in the industry. I now read the habits of reading the literature every day. He cultivated me. He has strict requirements on people and throw my medical records. "

Forty years of joining the neurology department, Professor Wang was the dean of Tiantan Hospital. Talking about the main reason to join Temple Hospital, Professor Wang did not hesitate to say that it was because of the personal charm of Professor Dai Jianping, then the dean of Tiantan Hospital. In 1999, because of the Beijing Science and Technology Star Program at the time, Professor Wang had the opportunity to go abroad as a postdoctoral, and stayed at the University of Arkansas Medical College for nearly two years. In a late -night cross -Oceanic phone, Professor Wang sat on the floor and talked to Dean Dai for an hour. He bought a ticket to return to China the next day and decided to return to China to take a look. "Two years abroad, I have imagined what Chinese neurosaidum is like, and no one at that time made me realize it." Professor Wang said, "But Dean Dai described me a dream. He said that this department said this department. You can do it again according to any imagination of your imagination. "

"I came back to the interview. At that time, I was from a bunch of candidates around the world. In the end, I interviewed 3 people." Professor Wang said that he is not the best choice. "Then I know, I'm worth coming back."

With the concept of win -win cooperation and international vision learned abroad, as well as the strategic thinking learned by MBA, and the support of several deans, in the context of China's good economic environment, Professor Wang finally used the altar for the Temple of Heaven. The neurology department of the hospital made a strategic positioning, carried out a broad reform reform, and established a scientific research team of more than 100 people to lead the department's rapid development. It is also benefited from this that the CHANCE-2 research can be completed smoothly.

Industrialization, sub -track,

Let Teman Temple Hospital walk to the center of the world stage

In recent years, the field of cerebrovascular disease diagnosis and therapy has improved rapidly, but it is still very far from the level of international pioneers. Professor Wang said that China is now in the golden period of clinical research. It has both the government's high attention and rich patient resources, and the enthusiasm of Chinese doctors' research is unmatched by other countries. But there are also weaknesses, that is, scientific research capabilities and methods need to be improved. "So the next step, cultivating doctors scientists, which is Physician Scientist, is a way that must be taken in the future." Professor Wang said. Clinicians should understand scientific research because he can find clinical needs most accurately, and then establish a clinical research center to allow professional research teams to support clinicians. "I opened the Department of Clinical Trials at the Capital Medical College, which is also the first pharmaceutical medicine major in the country. At present, China has jumped to the world's leading first formation in the field of cerebrovascular disease. I believe that as long as we have a group of people with enthusiasm, blood, ability, and international thinking, the position of China's innovation in the world will become better and better in the future. "

Regarding the future of Tiantan Hospital, Professor Wang said: "The government has planned us to plan us, that is, letting Temple Hospital walk to the center of the world stage as soon as possible. As the dean, I have the responsibility to accelerate this dream into a real process." The world The revenue of first -class hospitals comes from scientific and technological innovation. For example, more than 70%of Harvard Medical College of Medical College comes from scientific and technological income. Only less than 30%come from patients. In contrast, almost 100%of hospital income comes from patients. "This year, we need to do transforming medical industrial parks, return to the hospital with industrialized income to reduce the burden on patients. It also needs to be managed by the track, including personnel reform and performance reform. All supportable support is given, and the next step depends on the dean. "Professor Wang told us," In 2030, the hospital's scientific and technological output can account for 30%of the total income. "

In addition, the Temple Hospital will deploy three branches in the region where the neurological system is the weakest in the country, including Anhui, including the 70%outflow rate of neurological patients, which helps to achieve medical treatment.

Professor Wang also has a dream, that is, by 2030, China's cerebrovascular disease evidence can account for 30%of global evidence. Let China's voice spread to the world. In addition to strengthening scientific research capabilities, there are more windows that can mainly publish Chinese evidence. The SVN founded by Professor Wang 4 years ago is the first SCI journal representing China in the world. The second largest magazine in the vascular field. "This definitely requires the efforts of several generations. Our magazine is just 4 years old, and there is still a long way to go in the future." Professor Wang said with a smile.

Source: Medical Community

Responsible editor: Zheng Huaju

School pair: Zang Hengjia

August 13, 2022

The 3rd "Taishan Award" awards event

Will be held in Shanghai

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