Chinese and foreign researchers: China discovered "Langya", a new human animal suffering from virus, and 35 cases of infection were known

Recently, the global authoritative medical magazine "New England Medicine" (NEJM) published a communication article in cooperation between Chinese and Singapore scientists. The article claims that a new animal origin can be found in Shandong and Henan, China and Henan, China Henipavirus. The author named it Langya Henipavirus (Layv).

Professor Liu Wei, Professor Fang Liqun, Duke-Singapore National University Medical College Wang Linfa and other scholars pointed out in this study that a newly discovered, maybe a newly discovered, may come from animal Heng The Nipa virus is related to some heating cases. The symptoms of these infected people include fever, fatigue, cough, anorexia, myalgia, nausea, etc. This discovery is worth further studies to better understand the relevant human diseases.

"This virus belongs to the same genus as the Nipoper virus. So far, these cases are not fatal or very serious. Therefore, it can be said that (we) should be vigilant about this new virus, not panic. But we need to be careful Because there are more similar viruses in nature. If there is a different virus jumping on humans, the situation may be different. "One of the above researchers, Professor Wang Linfa, the National University of Singapore, Professor Wang Linfa .thepaper.cn) said.

Layv natural host or 鼩鼱

Hennepa virus is one of the important emerging causes of people and animals in the Asia -Pacific region. There are currently two viruses in this virus that can be infected with humans: Hendra Virus (HEV) and NiPah Virus (NIV). The natural hosts of these two viruses are fruit bats. Both viruses can cause severe diseases of animals and humans, and are listed as a biological safety level 4 virus with a mortality rate between 40%and 75%.

However, scientists have also found other related Hennepa viruses in bats, rodents and mammals (a mouse mammalian). In the above studies, scientists have found a new kind of new ones in a patient's throat sample in the whistle of the fever patients with a history of animal contact in the eastern part of Eastern China. Henna virus and named Layv (Layv).

Layv's genome is composed of 18402 nucleotides. Its genomic tissue is the same as other Hennepa viruses. On the system development tree, it is found that the strain is a new strain. Nipoper virus is the most related.

Further investigation found that 35 patients with acute LAYV infected were found in Shandong and Henan, China, of which 26 were infected only LAYV (other pathogens were not detected). The clinical symptoms of these 26 patients include fever (100%), fatigue (54%), cough (50%), anorexia (50%), myalgia (46%), nausea (38%), headache (35%) , Vomiting (35%), accompanied by platelet reduction (35%), white blood cell decrease (54%), damage to liver function (35%), and renal damage (8%).

In the study of livestock serum learning, it was found that goat (3/168 [2%]) and dogs (4/79 [5%]) serum antibodies were positive. Among the 25 kinds of wild mammals studied, LAYV's RNA (71/262 [27%]) is mainly detected in the body.

Researchers pointed out that although this study does not meet Koch's assumptions (a law that is used to build a causal relationship between disease and microorganisms), the following discovery tips from patients with acute LAYV infection, Layv is the cause of these patients' fever diseases. : Among the 35 patients with acute LAYV infection, 26 (74%) were detected only LAYV; in the acute and recovery period of patients of patients, 86%of the recovery period IGG titer was 4 times the acute stage serum. ; Virusmia is associated with acute LAYV infection; the virus load in patients with pneumonia is higher than that of non -pneumonia patients (average [± SD] log10 Copies/ml, 7.64 ± 0.98 vs. 4.52 ± 1.13).

No one can be passed on whether Layv can be passed on

Although the previous report showed interpersonal transmission of Hennipo virus, researchers pointed out that no cases and LayV monomer types have obviously gathered in space or time. There is no close contact history and a common exposure history between different patients, reminding that the infection of the crowd may be distributed. Nothing about 9 patients and 15 close contact with family members did not find the close contact of LayV, but the researchers also acknowledged that because the sample volume was too small, it was impossible to determine the situation of Layv's interpersonal communication. The possible cross -reaction between the Nipa virus to improve the detection method of serum science.

Finally, the researchers pointed out that Layv, as a newly discovered Hennipo virus that may come from animals, is related to human fever diseases. This discovery deserves further research to better understand related human diseases.

For the Henny Po virus, the World Health Organization pointed out that once there are suspected cases, they should be quarantined as soon as possible, and infection control measures should be taken as soon as possible to immediately notify the public health authorities.

After human infection belongs to the Hentera virus, which belongs to the Hennipo virus, the milder can manifest as a mild influenza -like disease.Human infection Hendella's mortality rate is 50%to 75%.Fortunately, it is not infectious.When human infection belongs to the Nipoper virus that belongs to the Hennepir virus, milder can be manifested as asymptomatic infection. In severe cases, acute respiratory syndrome and mortality encephalitis may occur.In 1998, the Nipoper virus was popular in the Pig group in Malaysia and caused 265 people infected, of which 105 were dead.This story was later adapted into the movie "Infectious Disease" and was widely known.There is no vaccine and treatment of Hennipo virus.The only treatment method is supportive care to control complications.According to the World Health Organization, the death rate of Hennepa virus is between 40%and 75%, which is much higher than the new coronal virus.

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