After 6 hours of death, the whole body "resurrected", the Chinese author explained in detail "reversing life and death"

On August 3, the paper was published in "Nature" magazine

On August 3, a research team at Yale University published a heavy study in the Nature magazine. They successfully resurrected the 6 -hour death of death through new technologies, and important organs resumed blood flow. The co -author of the paper, Zhang Shipei, said in an interview with Zi Niu journalist on the 5th that this study refreshed people's understanding of death. In the future, it is possible to get "dynamic organs" in the future. Source of human organs. The whole resurrection of the pig who will be dead for a while is still a very difficult thing, and it needs to be studied.

The brain of resurrection of death 4 years ago

Mammals need oxygen to maintain the vitality of cells and tissues. Once a few minutes of ischemia, intracellular acid poisoning and edema will occur, causing cell death, and tissue and organs will lose their function irreversible.

The team of Professor Nenad Seastan of Yale University was injected into a solution 4 hours after the pig died. As a result, he saw that dead brain cells could be resurrected. In 2019, the study of the resurrection of "4 hours of death" was reached on the cover of "Nature".

Since then, the research team has begun to explore whether this technology may be used to restore the entire body.

6 hours of death organs recover blood flow

Doctoral students from China are the common author of the latest papers. In 2016, Zhang Shipei graduated from the School of Pharmacy of Sun Yat -sen University, and then went to the Karolinska Medical College of Sweden for a master's degree in study, began to study the central nervous system, and then completed the master's degree design in Massachusetts Institute of Technology. Democratic study.

She is the co -authors of this chapter. Under the leadership of Professor Nenad Seastan, she took the lead with a number of experts to participate in and dominate the item. Revolution of laminarium.

Pork liver and kidney cells after recovery

She told Zi Niu Journalist that this technology is mainly composed of three parts, including 1, in vitro circulation irrigation system (mechanical simulation of other organ functions of the body includes dirty, lung and kidney, etc.); 2. A variety of drug combinations promote cell recovery); 3. The separation technology of the brain (connect the brain to the machine).

Zhang Shipei said that after the successful pig brain of resurrection and death, they upgraded the system, adjusted the design of the circulating irrigation machine, and optimized the puppet of the irrigation solution to better help the repair and suppression of multiple organs to better repair and suppress the inhibitory of various organs. immune response.

Organex technical schematic diagram

The new system was named Organex. In order to test its effect, the research team anesthesed pigs to induce dirty organs to stop. After waiting for pigs to die 1 ⼩, the piglets were filled with cycle. After the ORGANEX injection at the 6th time, many important organs including the brain, dirty, kidney, and liver tubes in the ⼩ 6 6 6 6 6 ⾎ ⾎ ⾎ 6 6 6 6 6 The cell damage caused by the time is also fixed.

Artificial cardiopulmonary device ECMO has been applied clinically and has long been well known. The Organex and ECMO involved in Zhang Shipei are very different. The research team deliberately used ECMO to compare the most. It was found that in the ECMO control group, after 6 ⼩ perfusion, the pipe tube method in the pig body that died 1 ⼩ was effectively recovered by effective recovery At the same time, the body of the pig will become stiff, and the various organs are swollen to varying degrees of bruises and produced spots. These are not in the Organex group. On the cell layer, ECMO has far from reaching Organex's repair capacity.

ORGANEX technology restores the organs of the pig's body to the ducting cycle, but it is difficult for the ECMO group to achieve similar effects.

They found that through the ORGANEX technology, the relevant pathway of the cell restoration of the layer of the layer was activated, and observed that the cycle and some cell functions were restored in the organs that were absent from the damage. The frontal leaf also includes dirty, kidney, and liver, such as dirty, liver, etc., which are often short -short in clinical transplantation, and see the phenomenon of moving the main limbs without the main limbs.

It may broaden the source of organs and organ

If you can develop this technology and should be used to make some organs that are not suitable for transplantation due to lack of ⽽, maybe it can become a treasure, increase the number of transplantation organs from ⽽ patient. At the same time, they also hope that related technologies can help other damage caused by lack of crickets, such as Zhongxuan.

She said that in this item, especially in the single -cell sequencing part, many Chinese scholars have made important contributions.

Zhang Shupei told reporters that Brainex and Organex re -refreshed people's understanding of death. Little is on the cell layer and division layer. In terms of organs, they are not sure if they can achieve real repair in the future, and the entire resurrection of pigs who died for a while is still a very difficult thing. In the future, they need to enter a step -by -step research. Yangtze Evening News/Zi Niu Journalist Song Shifeng

Edit: Qin Xiaoyi

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