The Wuhan University team found a new plan to promote cholesterol arranges

The Yangtze River Daily Da Wuhan Client August 5th (Reporter Hu Yihua Intern Li Yao) There are more and more cardiovascular diseases caused by high concentration of cholesterol. Is there a way to discharge cholesterol out of the body, thereby reducing the chance of cardiovascular disease?

On August 3, Professor Song Baoliang Laboratory of the Academy of Chinese Academy of Sciences and Dean of the School of Life Sciences of Wuhan University published a paper in Nature (Nature ") to reveal a new strategy to reduce blood lipids. This means that the previous drugs were suppressed or absorbed by cholesterol synthesis, and the research of Professor Song Baoliang's team found a new solution that effectively promoted cholesterol.

Professor Song Baoliang (left) and team members. Image source: Wuhan University Official WeChat

Cardiovascular diseases caused by high concentration of cholesterol are increasing, and lipid -lowering is a necessary means to prevent and treat cardiovascular disease. The existing lipid -lowering drugs, such as Jetin, Yizhuo Maibu, PCSK9 inhibitor, can reduce blood lipids to varying degrees, but there are certain side effects and limitations.

Professor Song Baoliang's laboratory in the paper published in "Nature" for example: Hisine and PCSK9 inhibitors can enable cholesterol in the blood to enter the liver, change cholesterol distribution, and increase the risk of liver burden. Limitated fats and so on.

Professor Song Baoliang's team. Image source: Wuhan University Official WeChat

Due to the structure of polynehide of cholesterol, it is difficult for human cells to degrade cholesterol molecules efficiently. Professor Song Baoliang's team researcher believes that if cholesterol can be discharged out of the human body, it will be an ideal lipid reduction strategy. Earlier, lipid -lowering in the form of cholesterol arranges, other research teams have tried, but they did not succeed.

ASGR1 is a sugar protein receptor found in the 1970s. It mainly expresses the liver cell membrane, combined with saliva protein in the blood, and swallowed it to degradation to the oscope.

After repeated research, Professor Song Baoliang's research team found that ASGR1 caused an increase in ABCG5 (gene) and ABCG8 (gene) expression. The latter discharged cholesterol into bile, and cholesterol further left the body through feces, which greatly reduced blood and lipid levels in the liver.

Researchers have also developed ASGR1's neutralized antibodies, which can effectively promote cholesterol. "This antibody can be understood as a prototype of a drug. We tested on mice and found that it could reduce the total serum cholesterol level of mice by 50%and reduce the level of serum triglyceride by 22%." Wang Juqiong, a postdoctoral post doctors of the School of Life Sciences of Wuhan University, said that this study laid an important foundation for the research and development of lipid -lowering drugs that promoted cholesterol.

In the field of cholesterol metabolism, Professor Song Baoliang, an academician of the Chinese Academy of Sciences and Dean of the School of Life Sciences of Wuhan University, has a series of important original discovery: clarify the molecular pathway of small intestinal cholesterol, reveal a cholesterol synthesis regulation pathway, discover intracellular cholesterol transportation The new ways and methods have made important contributions to the research of fat metabolism in my country.

It is understood that this research has laid an important foundation for the development of lipid -lowering drugs that promotes the exotic of cholesterol.

[Edit: Deng La Xiu]

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