Shandong Provincial Third Hospital: Best the "blood" with hematopoietic stem cell transplantation as the ultimate weapon

What is blood?

The source of human life!

Once blood problems occur, life may endanger life at any time.

In the Department of Hematology of the Third Hospital of Shandong Province, there are patients with 7 -year -old recycled obstacle anemia, 22 -year -old patients with high -risk acute leukemia, and 56 -year -old multi -occurrence osteoma patients ...

The critical condition, the test of life and death, the desire of life ... is their common point.

And this is also the test of Yu Yan, the director of Yike, as the first team.

Each patient is a new question, and every treatment is a new battle.

Yu Yan led the "soldiers" of the department to live up to expectations, using hematopoietic stem cell transplantation as the ultimate weapon, and brought hope for these severe hematological patients.

7 -year -old recycled disorder anemia girl can run and jump

At the age of 7, when the vitality was infinite, he ran, played, and played with his companions.

However, Yingying, this 7 -year -old child is difficult to have such happiness.

At the age of 3, bleeding due to unknown reasons, blood routines reminded anemia and platelet reduction, and was diagnosed as "renewable disorder anemia."

It sounds anemia, but this disease is not the same as ordinary anemia. It means that there is a problem with Yingying's bone marrow, and it is no longer possible to produce enough blood used by the human body. If it is extremely severe regenerative disorders, patients may have severe infection and bleeding at any time, and death risk may occur at any time.

At the beginning of the disease, Yingying's condition was basically stable through oral immunosuppressives ,rogen and traditional Chinese medicine preparations. However, in 2021, Yingying's physical indicators suddenly decreased, and the blood image became lower and lower, and blood transfusion was needed every month to maintain life.

Parents move to multiple hospitals, and the final answers are: hematopoietic stem cell transplantation can completely cure this disease.

If you want to transplant, you must find the appropriate bone marrow supply. The higher the height of the HLA (human white blood cell antigen) of the supply body and the receptor, the lower the rejection reaction. The minimum degree of anastomosis should not be less than 50%, which is semi -combined. For patients with disorder disorders, if semi-phased transplantation is performed, there will be a 20-30%chance to die due to complications.

The matching results of Yingying's relatives show that Yingying's parents and Yingying are half -phase. And this means that the difficulty of transplantation is mentioned the highest.

In the end, the parents of Yingying chose to provide the blood department of the three hospitals for transplantation. Director Yu Yan's many years of transplantation surgery has added a security lock to this surgery.

On May 31, Yingying's hematopoietic stem cells were adopted and then entered into her daughter's body. Although Yingying had fever and bleeding during the treatment process, she was soon controlled by experienced medical staff.

On the 13th day after "changing blood", Yingying white blood cells began to rise! On the 15th day of testing, Dad's cells were completely implanted in her daughter's body. Since then, she has not blood transfusion and platelets.

In WeChat, Yingying often reports to Yu Yan about her situation, and what she cares about most is "Auntie, can I eat fried chicken? Can I eat watermelon? ..."

For this 7 -year -old child, the biggest confusion is no longer life and death, but the trivial matter of life.

Half -phase transplantation, 22 -year -old girl successfully separated from high -risk leukemia shadows

Compared with Yingying, the 22 -year -old Zhang Meng (pseudonym )'s condition came suddenly and violently.

A few months ago, Zhang Meng chose to buy drugs for treatment due to frequent oral ulcers and toothache. Not only did he not improve, but he also became more and more serious. Go to the hospital for examination, high -risk myeloblast leukemia, this diagnosis is like a thunderbolt, bombing in Zhang Meng's ears, and also causing her and her family to be desperate.

At this point, Yu Yan gave them hope: stem cell transplantation surgery.

In the same way as Yingying, Zhang Meng can only choose his father's donor to perform semi -phase combination surgery.

Before transplantation, chemotherapy must be performed, that is, to remove malignant cells in the bone marrow through chemicals. This process will inevitably hurt the healthy cells in the bone marrow and cause certain damage to the body's organs.

Therefore, after chemotherapy, the bone marrow suppression period, the patient's immunity is extremely low, and the probability of merging infection has greatly increased. It is not uncommon for clinical cases that are life -threaded due to chemotherapy infectious shock.

In the process of chemotherapy in three courses, the problem followed. First of all, oral ulcers and fever; then lung fungal infections occurred. Fortunately, Yu Yan and her team accurately gave symptomatic treatment with rich experience in diagnosis and treatment. Let Zhang Meng get the opportunity to do transplantation, and there is no serious infection and acute rejection in the transplantation. 13 days after transplantation, Zhang Meng's hematopoietic function began to recover to achieve fully implantation. This means that her hematopoietic stem cell transplantation is successfully completed.

On the day of the transplant ward, Zhang Meng deliberately changed a small red dress and wore twist braid wigs. She said: "I want to meet the new life in the best state."

Many people think of leukemia. "Actually, this idea is wrong." Yu Yan introduced that leukemia can also be treated and even cured. The key is to make the correct judgment to determine the follow -up treatment. Transplantation surgery is not the last choice of leukemia patients, but to choose the right timing of transplantation, perform surgery at the most suitable time, which will greatly improve the patient's survival time and quality of survival.

Among Yu Yan's patients, "after transplantation, multiple patients have survived for fifteen or six years, and even set up families, with children."

It was not infected throughout the process, and patients with autologous cell transplantation were smoothly out of the anemia and pain in the waist and legs. This problem seemed to happen to the elderly. Sexual bone marrow tumor.

Cheng Dong (pseudonym), 56, did not expect that he had suffered from this disease because he was weak and bone pain.

According to Yu Yan, osteoma is a malignant tumor that originated from the pulp cells in the bone marrow. It occurs mostly in the elderly. The incidence is high, but the hiddenness is strong. The clinical manifestations are mainly symptoms such as anemia, bone pain, renal insufficiency, infection, and bleeding.

For the treatment of multiple osteoma, autologous hematopoietic stem cell transplantation is the best choice.

What is autologous hematopoietic stem cell transplantation?

This refers to the use of the patient's own hematopoietic stem cells for preservation, and then passes through pre -treatment, strong chemotherapy, and then loses the saved stem cells back to the patient.

Yu Yan introduced the metaphor of the image: if human blood was compared to the field, the crops such as rice, wheat and other crops on the ground were constantly set out to provide energy to the human body. Multi -myeloma is equivalent to a lot of weeds on this land. These weeds will gradually affect normal crops, and even make the land full of grass. The doctor is to remove all the grass on the ground and then sprinkle the seeds again. The seeds come from the normal crops on the ground.

However, in order to prevent weeds from mixed in it, the doctor should first conduct a chemotherapy of one or two courses to allow the bone marrow to fully relieve, that is, there is no tumor cells. At this time, the seeds can be collected and saved. This collection process usually requires multiple times to meet the needs of transplantation.

Due to multiple osteoma is the misfortune of Cheng Dong.

When encountering Yu Yan's team, it was Cheng Dong's luck.

On June 15, Cheng Dong entered the transplant layer flowing warehouse.

And entering the transplantation layer streaming warehouse, this battle is just the beginning.

Before transplantation, patients need to pass the pre -processing. Within a week, patients are taken oral antibiotics, reducing the harmful bacteria of the intestine, and conducting systemic chemotherapy, thereby inhibiting the body's immune function, reducing the number of blood cells, so as to facilitate the implantation of hematopoietic stem cells.

From the beginning of blood cells, to the return of hematopoietic stem cells, the process of completely recovering the blood cell count is called the bone marrow suppression period. And this process is the most vulnerable time in the human body.

Just threw a naked baby into the snow and snow.

Once infected, patients will experience high complications such as high fever, chest tightness, shortness of breath, and skin mucosal bleeding. In severe cases, infectious shock, heart failure, gastrointestinal tract or cerebral hemorrhage may occur, leading to death.

After implantation of hematopoietic stem cells, the treatment of complications is the real test of doctors.

During this time, Cheng Dong could only rely on Yu Yan and her team.

And Yu Yan, live up to the entrustment.

One month later, Cheng Dong went out of the position smoothly and was not infected throughout the process.

how did you do that?

"There must be detailed and mature solutions before surgery." Faced with this problem, Yu Yan admitted that "after surgery, it is more relying on rich experience." Taking fever as an example, a fever is infected with fever. If it is a rejection, it is necessary to add hormones, but if it is infected, I need to reduce the amount of hormone as appropriate, mainly to be infected. Experienced doctors can quickly find the cause and perform targeted treatment. Patients recover quickly and reduce costs.

At present, all doctors have participated in the standardized training of national hematopoietic stem cell transplantation in the blood department Yu Yan team. Most doctors have 10 years of transplantation experience or more than 5 years of transplantation surgery experience.

Perhaps this is the confidence of the blood department, and it is also the guarantee of "blood" for the patient.

Expert introduction:

Yu

Director of Hematology, Deputy Chief Physician, Doctor of Medicine

Qilu health and healthy talents. Good at standardized diagnosis and treatment of various types of good and malignant hematopoietic stem cell transplantation technology. He is the executive member of the Hematology Branch of the Shandong Province Research Hospital Association, a member of the Hematology Branch of the Shandong Medical Association, a member of the Shandong Medical Association Stem Cell and Cell Specialty Committee, a member of the hemophilia branch of the Shandong Provincial Rare Disease Prevention and Treatment Association Member of the Joint Committee of Multi -Disciplinary Committee of the Association, member of the Youth Committee of the Shandong Medical Association Blood Physician Branch. From 2015 to 2016, he served as a visiting scholar at the University of California's Moores Cancer Center.

Disposal time: all day on Monday, Tuesday morning

Source: Third Hospital of Shandong Province