Emergency patients with complicated condition and too large number?Experts say that this is the advantage of scientific research!Intersection

Scientific research face

Medical Daily (Wang Lu Wang Lu) clinical research design is an important part of clinical research. Only rigorous, scientific and reasonable clinical research and design may have reference significance for clinical issues. But for most clinical medical care, scientific research is like a "big mountain" that is difficult to overcome. Whenever you stand at the foot of the mountain, you don't know where the first step should be.

In 2022, Mai Rui joined for dozens of hospitals with the top tense, emergency, and breathing experts. Combined with actual cases, from the topic of selecting, designing, implementing, analyzing, writing, submission, etc. Through practical and powerful interaction content, scientific research ideas and implementation methods, write standards and submission skills, and pass on clinical medical staff to help them face the "big mountains" of scientific research, clear mountain -shaped paths, find the best mountaineering route, go through the mountains and ridges together Essence

On July 28, the second phase of the "Scientific Research Facial · Emergency" was coming, including multiple media, including the medical newspaper live broadcast center and medical TV, and the viewing volume exceeded 260,000!

Taking the acute seizure of the disease as the starting point

Many doctors in emergency department often face a common problem, that is, the work and research content of the emergency department often cover all directions of women and children internal and external. As we all know, the clinical characteristics of emergency medical department are fast work rhythm, no distinction between day and night, the most concentrated critical condition, the heavier rescue management tasks, and the most contact type. And in the face of such a huge clinical task, scientific research is indeed worthy of considering emergency doctors. Professor Zhang Dongshan, deputy leader of the Clinical Association of the Chinese Medical Association and the deputy leader of the clinical science group of the Clinical Society of the Emergency Medicine Branch and the director of the Emergency Department of Xiangya Second Hospital of Central South University, emphasized that in order to consolidate the research direction with emergency characteristics, we must focus on the progress of the disease. In terms of acute aggravation period, attention to the balanced stability of the body's organs, highlight the outstanding characteristics of emergency department.

The daily work of the first -line doctors of the emergency department is too busy, the subject and funds are insufficient ... The busy emergency people who are busy all day often hinders the footsteps of scientific research because of such reasons. In this regard, Professor Zhang Dongshan expressed his view. He believes that scientific research and clinical practice are essentially uniform. Scientific research is to better improve clinical clinical, improve the accuracy of clinical diagnosis, improve the effectiveness of clinical treatment, and strive to make patients from follow from Benefits in the study. Therefore, it is not necessary to be scientific research in the laboratory. The practical problems encountered in clinical practice may also become good scientific research materials.

In order to combine scientific research and clinical effectiveness, the first is to establish a biological sample library to accumulate sufficient case samples.

The second is to be good at using medical public databases such as NHANES, MIMIC, SEER, so as to tap to find their own research directions and content.

The third is to ensure comprehensive and continuous internal powers and proactive outflows. Professor Zhang Dongshan emphasized that scientific research should not fight alone, and understand that integrating resources is the correct way to develop scientific research. In addition to strengthening the cultivation of scientific research awareness of young doctors in the Department of Science and Technology (including scientific research inspiration and guidance, declaration of various funds, etc.), and improvement of basic knowledge reserves such as living faith; Cooperation, be good at using Xinxin analysis technology to avoid going into misunderstandings and rapidly enhance the pace of scientific research.

Based on the unique advantage of cross -discipline

"If you have never done a wrong job, it can be regarded as a scientist's serious and responsible, then it can also simply prove that the scientist lacks the courage and the first spirit." This sentence that Soviet physicist Migdar said, Beijing Professor Li Chunsheng, director of the Key Laboratory of Centers and Lung Resuscitation, deeply agreed. He also believes that the first spirit is one of the essential qualities necessary for scientific research.

Looking back at the history of medical history, many of them have been respected for a long time and are eventually identified as pseudo -propositions, but this also proves that science often needs long -term test and serious thinking. It is also because of this. Only the process of being courageous to verify.

Not all scientific research can obtain the expected results. It is often a process of trial and error. After research and implementation, the problem of proving the problem design, the problem of method and technology, or the feasibility of the feasibility. But this does not mean that everything can be tried. In response to this issue, he made a few reminders to the juniors of the emergency department: avoiding the content of pseudo -science; The topic of the topic, such as the idea that cannot be implemented in practice, etc.; You cannot use your own amateur to touch the professional content of others. Emergency is a typical cross -disciplinary discipline, so there are also unique research fields, such as how to distinguish between how to distinguish between and the formulation of the principles of diagnosis and treatment; the application of high -tech in emergency diagnosis and treatment.

Discussion session

Whether in the experimental design and clinical research session, researchers may be further diverged by some specific problems. To this end, in the discussion session of this live broadcast, authoritative experts gave standard answers to the basic but common questions in scientific research.

Q1

How to set and select the main end and secondary end

Professor Li Chunsheng: The main endpoint mainly refers to the main purpose that the RCT research institute wants to achieve, that is, researchers should clarify what the main problem he wants to study before research. The secondary end is the secondary issue inspected by the institute. Try to ensure that the research is valuable even if its final expected result is not obtained. Q2

What are the clinical research

Professor Zhang Dongshan: Clinical studies are the main research content of the diagnosis, treatment, prognosis, cause and prevention of diseases, with patients as the main research objects, and medical institutions as the main research base. Activity.

Patients with a certain disease with a certain disease are used as a case, and individuals who do not have the disease but have comparability as a control risk of exposing the various factors in the comparison case group and the control group. Research is called control research.

And queue research refers to the occurrence of a certain population to be exposed to a different sub -group according to whether a certain crowd is exposed to a suspicious factors or exposure. The difference in incidence is different, so as to determine a observation study between these factors and the degree of correlation between the end and the degree of association. Before that, we already know the involvement of these exposed factors, and discuss it, which is retrospective research; if a exposure factor exists, but its harmfulness and specific impact are not known, then the need to establish is the queue. Prospective research.

Q3

Where does the sample come from?

Professor Zhang Mao, deputy chairman of the Emergency Medicine Branch of the Chinese Medical Association: The scientific research sample volume often depends on the indicators required for the main endpoint of the research, and calculated based on the expected difference and inspection efficiency it required. If the new method is obvious compared to the traditional method, it is possible to complete the experiment through less samples; otherwise, a large sample amount is required, causing feasibility to decrease.

Q4

Thinking from research to transformation

Professor Lu Ben, deputy dean of Xiangya Medical College of Central South University: Heparin is a mammalian endogenous polysaccharide molecule and a commonly used anticoagulant drugs in clinical practice. It is because of its anticoagulation effect that heparin has the risk of bleeding clinically, especially for patients with severe illnesses. The team further separated the anticoagulation and anti -inflammatory effects of heparin, and invented a new method of treating purulent disease with non -anticoagulant heparin. Earlier, after the team initially discussed whether the HMGB1-Caspase-11 route was a target of potential drugs for purulent disease, the special HMGB1-Caspase-11 pathway inhibitor was established to find a selective inhibitory Caspase-11 route activation activation activation activation The pioneer, found and explained that heparin can prevent organ damage, DIC and death by inhibiting the activation of Caspase-11 in the activation of Caspase-11.

Q5

How to use the letter to help clinical research

Professor Ma Qingchang, member and deputy secretary -general of the Emergency Medicine Branch of the Chinese Medical Association: Although the patient's condition is relatively complicated, the patient's condition is relatively large, but due to the large amount of patients, it is easy to obtain massive patient data and parameters, so it has the characteristics of big data. In addition, all -encompassing data can be studied as a crowd. Based on these characteristics, as long as the appropriate entry point can be found clinically, you can use the majors related to the letter, and even artificial intelligence to obtain good scientific research results.

Capture: Wang Lu

Edit: Wang Lu

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