Notice of the General Office of the National Health and Health Commission on issuing unknown reasons for children's serious acute hepatitis diagnosis and treatment (trial)

Since March 2022, many countries and regions around the world have reported the serious acute hepatitis in children, and severe cases have been relatively high, which has attracted widespread attention. The cause of the disease is unknown, and there are no relevant case reports in my country. In order to prepare for medical treatment in advance, the State Health and Health Commission has organized the "Guidelines for the Diagnosis and Treatment of Children's Severe Acute Hepatitis (Trial)".

The guide pointed out that on March 31, 2022, five children reported that five children in the United Kingdom had severe hepatitis within 3 weeks, and children were 3 to 5 years old. On April 5, 2022, the United Kingdom reported to WHO that the unknown cause of acute hepatitis in healthy children under 10 years of age increased. Children had vomiting, jaundice, and high -rise aminase. As of May 20, 2022, the European monitoring system data shows that the disease can be seen in children at all ages, which are more common under 5 years of age; 14.1%of inpatient children need to live in severe care ward. On May 27, 2022, WHO announced that 33 countries reported 650 suspected cases, at least 38 cases of liver transplantation, and 9 deaths.

There is no obvious epidemiological association between various cases, and it does not support it as a contagious disease.

Causes and pathogenesis: The cause and pathogenesis of severe acute hepatitis in children are still studying.

At present, WHO believes that although the hypothesis of adenovirus infection as the cause of the cause has a certain rationality, adenovirus usually causes a mild and self -limiting digestive or respiratory infection of children with low age, which cannot fully explain the more serious clinical manifestations of the disease. Therefore, the correlation between the disease and the adenovirus needs to be further clarified. Most children have not been vaccinated with new coronal virus vaccines and do not support hypothesis related to the side effects of the new coronal virus vaccine.

Other pathogenic factors are still exploring. For example, during the popularity of new coronary pneumonia, the level of adenovirus is low, which increases children's susceptibility; new adenovirus occurs; adenovirus combined with new coronal virus infection; new coronal virus infection complications lead to super antigen media media Immune cells activated, which causes children's multi -system inflammatory syndrome. The exploration of other pathogens is also underway, and non -infectious factors also need to be eliminated.

Clinical manifestations include acute onset, which are mostly manifested as fatigue and poor, nausea, vomiting, diarrhea, abdominal pain and other digestive tract symptoms. Liver enlargement, fever and respiratory symptoms, individual may have spleen enlargement. A small number of cases can progress in a short period of time to acute liver failure, and jaundice has performed aggravation and hepatic encephalopathy.

The guide also guides the definition of cases, laboratory testing, treatment, etc. in detail.

The guide said that the prevention and control of hepatitis of children's hepatitis includes strengthening hand hygiene and paying attention to wearing masks and dietary hygiene. In clinical work, medical personnel need to take standard prevention measures. Once a suspected case is found, it should be reported in time as required.

Source/ CCTV News Health China

Edit/Tao Tao

© Jiangsu News

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