Age -related B cells can cause rheumatoid arthritis

Science and Technology Daily (Reporter Wu Changfeng) Recently, a reporter from the Science and Technology Daily learned from the First Affiliated Hospital of the University of Science and Technology that Professor Chen Zhu's team of Rheumatology and Immunology Department of the hospital has made important progress in the study of rheumatoid arthritis pathogenesis. Their research revealed the age -related B cells (ABCS) to promote the onset of rheumatoid arthritis (RA) and molecular mechanisms by activating into a fiber -like synovial cell cell (FLS) to develop targeted specific B cell therapy in the future. The method of rheumatoid arthritis provides a basis. Related research results were published in the International Rheumatology Journal of Rheumatology Newspaper Year recently.

Activated into a fiber -like synovial cells is the core effect cell in the pathogenesis of rheumatoid arthritis. Its interaction with immune cells is a key link for the incidence of rheumatoid arthritis. A age-related B cells are a special sub-group B cells found in recent years. They are characterized by secreting the marrow molecular CD11C and transcription factors T-BET, and are considered to participate in the onset of multiple autoimmune diseases.

The study found that the age -related B -cells related to the peripheral blood and slid -like patients with rheumatoid arthritis increased significantly, which was directly proportional to the activity of the disease. The analysis of the transcription group shows that the geneticization and adhesion -related genes are significantly increased in age -related B cells. Researchers have cultivated the age-related B cells and activated into fiber-like synovial cells for in vitro co-in vitro, and found that the leukocyte-6 (IL-6) and the matrix metal proteases secreted by fiber-like synovial cells were significantly increased. Cell contact non -dependence. Further through the analysis of the transcription group and in vitro molecular experiments, the researchers found that the age-related B cells were induced to activate the activation of fiber-like synovial cell cells by secreting tumor necrosis factor α (TNFα) and its mediated ERK1/2 and Jak-STAT1 pathways. Essence

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