Latest study: Hepatitis of unknown causes of children is more likely to be the sequelae of the new crown

A few days ago, researchers from the Schneider Children's Medical Center, Belinson Hospital, Lanbam Medical Center, and Tel Aviv University published a paper on the journal "Pediatric Gastrointestinal Diseases and Nutrition". The article analyzes the clinical manifestations and laboratory test results of 5 patients with hepatitis of children with unknown causes received by Schneider Children's Medical Center. It is believed that the so -called "unknown cause of children with hepatitis" is more likely to be caused by new coronal virus infections, and adenovirus is not the culprit. The paper has passed the peer review.

The article introduces that five patients have been infected with new coronal virus before the symptoms of hepatitis:

The first case is that a 3 -month -old baby experienced acute liver failure and received liver transplants after 21 days of positive new coronal virus testing. After admission, the new coronary virus and adenovirus test were negative;

The second case is a 5 -month -old baby who is hospitalized due to fever, jaundice and hepatochromic, worsens and liver transplantation.

The third case was a 8 -year -old boy who began to occur after 130 days of the new coronal virus detection.

Case 4 is also an 8 -year -old boy. After 90 days of positive new coronal virus testing, hepatitis symptoms such as high fever, jaundice, and diarrhea were started.

Case 5 is a 13 -year -old boy. This case is accompanied by symptoms such as weakness, diarrhea, jaundice, etc. in the new coronal virus detection. The hospital believes that there is no need to treat and "heal" after 39 days. Symptoms such as vomiting, abdominal pain, jaundice, hepatoba, and liver injury are positive.

Researchers have found that this kind of unknown cause of hepatitis in babies and children is different. Both babies have acute liver failure, while the other three children over 8 years of age are mainly manifested as acute hepatitis and cholecoscopic accumulation.

In response to the hypothesis that the adenovirus infection on the adenovirus infection caused by hepatitis in children, the researchers specifically analyzed the liver biopsy samples of the patients. As a result, no adenovirus antigen was found, and there was no histological characteristics of hepatitis of adenovirus. Therefore Infection is the culprit of hepatitis. "

Researchers pointed out that the new coronal virus can cause hepatitis through two ways. First, the new crown virus directly via the rich ACE2 receptor to invade the liver through the bile duct cells, that is, "direct virus damage". The basis is that the above five patients are asymptomatic or mild new crown cases. Liver damage; the other is the immune system disorders caused by the new coronary virus infection. The basis is that the second case is called secondary blood -stuffing lymphoma tissue cells (HLH). Suppose that after giving steroid drug treatment, multiple patients have improved.

Although the cases involved in this paper are limited, one of the author of the paper, the gastrointestinal disease expert of the children's gastrointestinal disease of the Schneider Children's Medical Center, said in an interview with the Israeli media that comprehensive inspections found that all 5 children had previously been before before. Infected with new coronal virus and did not vaccinate. After that, they received eight children with unknown cause hepatitis, and they could only identify the relationship between the infection with the new coronary virus. At present, the connection between this set of severe hepatitis cases and the new coronal virus makes them concluded that this situation is the result of the "long -term new crown". New coronal virus is more likely to be the main cause of hepatitis of children with unknown diseases.

Source: Science and Technology Daily

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