In the early stage of diabetes

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"2021idf Global Diabetes Map (10th Edition)" shows that it is estimated that there are 537 million diabetic patients worldwide, and about 6.7 million adults died of diabetes or complications in 2021. Cerebal vascular disease (CSVD) is one of the common cerebrovascular complications of diabetic patients, and one of its signs is that the brain white signal (WMH) appears in imaging. Multiple studies have confirmed that abnormal changes in the micro -structures of the brain white matter are the cause of diabetic neuropathy.

A few days ago, Professor Wang Yongjun, a professor of Beijing Tiantan Hospital affiliated to the Capital Medical University, published a research results based on crowd -based forward -looking queue, suggesting that patients have undergone abnormal changes in the micro -structures of the brain white quality in the early stage of diabetes, and this change and high blood sugar level have caused the level of high blood sugar levels to cause the level The metabolic disorders are closely related. (Ebiomedicine. Online version of July 7)

Researchers evaluated the damage of all participants' brain white quality through imaging examinations. The results show that compared to normal blood glucose, the pre -diabetes and patients with diabetes are generally higher, cardiovascular risk is greater, and WMH is also larger.

The researchers at the same time compared the integrity of the white -quality area between different groups, and found that there was no statistical difference compared to the normal blood glucose group compared with the normal blood glucose group.

It is worth noting that the early sub -group of diabetes that combined with an empty blood glucose damage (IFG)/sugar -resistant (IGT) occurs abnormal on multiple indicators, suggesting that the white -quality structure of the brain is abnormal; There is no statistical difference between the Asian group and the normal group of blood sugar. Compared with the normal blood glucose group, the diabetic group is more widely distributed in the brain.

The results of the study suggest that the abnormal changes in the micro -structures of the brain white matter have appeared in the early stage of diabetes, especially in patients with IFG/IGT, and the integrity of the brain white matter is significantly reduced.

The results of this study are of great significance to prevent diabetic neuropathy. Protected the integrity of the micro -structured brain micro -structure before the patient has not experienced IFG/IGT. It may be a key turning point for avoiding the damage to the micro -structural damage of the brain, which can effectively prevent changes in the nervous system caused by diabetes.

The research included in the 6 villages and 4 communities in Lishui City, China, and 3,067 residents, and finally collected 2,218 valid data, with an average age (61.3 ± 6.6) years, and 54.1%of women. All the subjects can check the blood glucose (FPG) and glycated hemoglobin (HBA1C) by blood. Among them, those without a history of diabetes receive standardized oral glucose tolerance test (OGTT), have a history of diabetes and are taking hypoglycemic drugs or using insulin. OGTT check.

Study divided 2218 subjects into 3 groups according to blood glucose value, namely the normal group of blood glucose (509 cases), the pre -diabetes (1205 cases), and the diabetes group (504 cases). It is divided into two sub -groups.

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