Chen Mao and Xiong Tianyuan: This international consensus tells you what to do on the two -leaf petal TAVI |

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In this issue of "Heart News" brings you 6 clinical research and 6 industry information for everyone in the field of cardiovascular. In this issue, Professor Chen Mao and Dr. Xiong Tianyuan, Professor Chen Mao and Dr. Xiong Tianyuan of Sichuan University.

"International Heart Research" main content

China's heart health recipe can effectively reduce blood pressure

On July 11, Professor Wuyangfeng in the Institute of Clinical Research of Peking University published a study in Circulation to evaluate the impact of Chinese heart healthy diet (CHH) on blood pressure. A total of 265 participants were included in the study and randomly distributed to the CHH food group and conventional food group (135 VS. 130). The CHH diet includes 4 versions of Lu cuisine, Huaiyang cuisine, Cantonese cuisine, and Sichuan cuisine.

After a month of observation, the results showed that the systolic blood pressure of the CHH diet and conventional dietary groups decreased by 15.0 mmHg and 5.0 mmHg, respectively, and the net difference between the between the two groups was -10.0 mmHg; the diastolic blood pressure decreased by 6.7 mmHg and 2.8 mmHg, respectively, and the net differences in the change of change were different. For -3.8 mmHg. Researchers believe that if you can adhere to China's healthy diet, it will reduce cardiovascular disease by 20%, reduce heart failure by 28%, and 13%of death.

Adding salt frequency is positively related to the risk of death

Recently, a study of European Heart Journal shows that the higher the frequency of salt added to food, the higher the risk of premature death, the shorter the life expectancy. The samples included in the study came from more than 500,000 people from UK BioBank, and the frequency information of salt added to food by questionnaires was collected through questionnaires.

在校正包括饮食、生活方式、社会经济水平、既往合并疾病等多个因素在内的分析显示，中位随访9年期间，与从不或很少往食物中加盐的人相比，有时、 Often, people who always add salt to food to eat early death risks increased by 2%, 7%, and 28%, respectively. Cardiovascular death (mainly increased risk of early stroke early deaths) and cancer death risk also show a similar increase, and fruits and vegetables The intake can significantly affect this risk correlation.

Cerebral hemorrhage combined with atrial fibrillation is also safe for anticoagulant therapy

Recently, a META analysis published by Stroke magazine shows that among patients with non -traumatic cerebral hemorrhage survival of atrial fibrillation, oral anticoagulant drug treatment can reduce thrombosis and all cause of death. Risk of recurrence. The META analysis is included in 2 random control research, 8 observation research, 8 queue research, and 2 META analysis based on observation research on individual data. The results showed that patients with oral anticoagulant drugs were treated with the risk of thrombosis by 49%, all due to death risk decreased by 48%, and the risk of cerebral hemorrhage recurrence did not increase significantly.

H2FPEF scoring diagnosis HFPEF is more advantageous

On July 13, a study published by Jama Cardiology showed that the diagnosis of HFPEF for outpatient patients who had difficulty respiratory reasons, the diagnostic performance of the H2FPEF score was better than the HFA-PEFF score and PCWP/CO> 2 mm Hg/(L. Min To.

The study incorporated 736 outpatient patients with unknown reasons, of which 563 were diagnosed with HFPEF, and the remaining 173 were used as control groups. The results show that H2FPEF and HFA-PEFF scoring system can distinguish between HFPEF patients and control groups, and the specificity of the two scores is stable, but the HFA-PEFF has a poor sensitivity. The pseudoma rate of H2FPEF score is 25%. 20%of patients are re -classified with PCWP/CO> 2 mm HG/(L · Min) diagnosis. This part of the patient has the characteristics of HFPEF typical clinical, ultrasonic heart dynamic diagram and blood flow dynamic characteristics, including 66%of patients with recreation patients. Rest on PCWP.

The CS staging method can improve the clinical application of the installment system

Earlier this year, the update of the American Cardiovascular Alarm and Intervention Society (SCAI) released the relevant consensus related consensus (CS), and was divided into five phases A, B, C, D, E. Recently, a study published by JACC Magazine tested the important parameters of the definition staging and further explored the effectiveness of these parameters as a predictive factor for the hospitalization mortality prediction factors.

It was found that the overall mortality rate of the queue was 35%. Among the patients with myocardial infarction, out -of -hospital cardiac arrest, and the increase in the number of drugs and equipment, the mortality rate was higher. Septic pressure, lactic acid levels, alanine amin amino metastase levels and the whole body pH value are significantly related to mortality and are used to define each stage. With these standards, the baseline and the highest stage are significantly related to mortality. Therefore, the heart -based shock working group believes that the staging method may improve the clinical application of the installment system and provide new reference for the treatment trajectory of patients with inpatient heartogenic shock.

Early myocardial blood transportation can reduce mortality rate

Recently, a study published by JACC magazine evaluates the interaction between myocardial ischemia between early blood transportation and mortality. Studies were included in more than 40,000 people, with a median follow -up of 11.4 years. Use the tendency scoring to adjust the non -blood transport reconstruction randomization, and use the multi -variable COX model to adjust the tendency score and clinical variable prediction ACM. The results showed that the frequency of myocardial ischemia was significantly different due to the low -left ventricular ejection score (LVEF) and different degrees of angina pectoris.

It was found among nearly 40,000 LVEF ≥ 45%of patients that early reconstruction of early blood transportation was related to the increase in death risk of ischemia -free patients, which was related to the decrease in the risk of death of patients with severe ischemia; Blood reconstruction has nothing to do with the benefit of the mortality rate of patients with no or mild ischemia, and is related to the decrease in the mortality of patients with moderate and severe ischemia. Therefore, early myocardial blood transportation was significantly reduced to the mortality rate of some patients, including patients with LVEF normal and severe induced myocardial ischemia, as well as patients with low LVEF and moderate or severe myocardial ischemia.

The main content of "industry mind dynamics"

The esophageal ultrasonic diagram opened a new window for cardiovascular imaging examinations of cardiac vascular imaging because of its special detection position and high -quality images. Recently, the FDA approved the world's first handheld meridian ultrasonic heart dynamic diagram (Tee) system, including Zura handheld blood flow dynamic ultrasound system and CLARITEE one -time demolition probe. Essence

Recently, Science magazine has published a new research result. Professor Kevin Kit Parker, Harvard University, through a new technology -Focused Rotary Jet SPINNNG (FRJS) to create a heart model with a real spiral structure. This technology can be reconstructed in strict accordance with the angle of the heart center muscle fibrous spiral arrangement, and the complex heart structure of a single or even four ventricles can be rebuilt. Through this technology, it will not only confirm the role of the heart spiral structure, but also show endless possibilities in more application scenarios.

Recently, relevant companies have announced that their dynamic digital radiation photography (DDR) technology will be used on the MKDR XPress mobile X -ray system to visualize the anatomical structure in motion. The mobile system will also be compatible with the latest technology of wireless tablet X -ray detector -Aerodr's glass -free high -definition detector. Aerodr -free glass tablet detector has a high detection quantum efficiency (DQE) and the smallest 100 µM pixels in the world, which can provide the resolution and image clarity required by clinicians, which helps better evaluate the dissection of patients' anatomy structure. In order to establish a national myocardial disease prevention and control network, the State Cardiovascular Center Cardiopathic Special Alliance has been formally established recently. At the launch meeting, Deputy Dean of Yang Weixian, Fuwai Hospital of the Chinese Academy of Medical Sciences on behalf of the National Cardiovascular Disease Center, read the "Decision on Establishing the State Cardiovascular Cardiosciser Center Specialist Alliance", and announced the first batch of member units of college alliances, guidance experts, guidance experts The list of committees, the list of executive expert committees, and the list of members of the expert working group.

Recently, the FDA awarded the first title of "Breakthrough Device" for the first phase -resolution ventricular treatment of heart failure equipment. Accucinch is a curved implant that fix it to the left ventricular indoor wall through the femoral arterial pathway to achieve the purpose of narrowing the left ventricle, reducing the stress of the ventricular wall, and supporting and strengthening the ventricular wall. Accucinch is the only instrument that can achieve the function of reducing the left ventricular dimension, reducing the volume of the left ventricle, directly supporting the left ventricular wall, and reducing the two -pointed reflux reflux.

On July 13, the world's first patients in the world were generated in the world to reduce LDL-C LDL-C. The gene editing therapy accepted by the patient is based on a single -alkaline -based editor -based modified by the CRISPR system. By changing a letter of the PCSK9 gene in the patient's cells, the effect of the PCSK9 loss is achieved. In further clinical trials, the safety and effectiveness of the "VERVE-101" monocyline-based editing therapy will be tested among 40 hyperchoral hypercholesmia patients. It is expected to report preliminary clinical data of the test test next year.

"Every week's heart comment" content summary

Review new views and talk about new trends. This is a weekly comments. Recently, a number of internationally renowned valve centers led by the Hearte Innochiatric Valinthic Wets of the West China Hospital of Sichuan University to complete the TAVI path chart of the binary aortic valve, and published it at Nature Reviews Cardiology. This path map provides consensus suggestions for the application of TAVI in the application of TAVI in the international expert group. In this issue, the author of this path diagram, Professor Chen Mao, and Dr. Xiong Tianyuan, the first author, jointly interpreted the consensus

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