World Famous Journal | Because of strokes, women have less than 10 million years of healthy life than men!Intersection

Dangerous!

Repeated abortion!

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Conclusion

Infertility, abortion, or death, often make the family that expects the baby's birth, and the pain caused by the woman's mind is even more painful.

The latest research published by British Medical Magazine on June 22 shows that infertility and miscarriage, especially recurrence of abortion (at least three times) and recurrence of death (at least twice), increasing women in the future of non -fatal and fatal and fatal fatalism in the future Risk of sex stroke.

It is recommended that women with recurrence or deaths should strengthen the monitoring of stroke risk factors (such as rising blood pressure, elevated blood sugar, and blood lipids), and carry out a healthy lifestyle planning (such as quitting smoking, maintaining healthy weight, exercise), and In order to reduce the risk of strokes in future life.

Research Background

Globally, stroke is one of the main causes of women's death and disability. In 2019, about 3 million women died of strokes. Women lost more than 10 million years of healthy life due to disability caused by strokes, 44%higher than men.

The current stroke prevention guidelines have identified some risk factors, such as obesity, hypertension, and diabetes, but these factors are not enough to explain the differences in the risk of men and women. A specific risk factors for women may need to identify women with higher risk of stroke.

So far, many studies have produced more and more evidence that there is a correlation between pregnancy complications (such as gestational diabetes and puzzle) and long -term risks of stroke, and infertility, abortion and death may pass endocrine disorders ( Such as low estrogen or insulin resistance), systemic inflammation, endothelial dysfunction, psychological disorders, unhealthy behaviors (such as smoking), and obesity increase the risk of stroke.

Study preparation

The study included in the queue research of seven countries participating in the life of reproductive health and chronic disease incidents (Interlace) alliances, including China, Australia, Japan, the Netherlands, Sweden, the United Kingdom, and the United States. Female aged 32 to 73.

Among the participants, 275 863 people have non -fatal and fatal stroke data, 54 716 people only have non -fatal stroke data, and 288 272 people only have fatal stroke data.

Analysis conclusion

■ Infertility is related to increased risk of non -fatal stroke (the risk ratio is 1.14, 95%of the trusted interval 1.08 ~ 1.20).

Analysis of non -fatal stroke Asian types show that infertility is related to increased risk of ischemic stroke (see Figure 1).

figure 1

■ Recurrent miscarriage (at least three cases) and non -fatal (risk ratio 1.35, 95%trusted interval 1.27 ~ 1.44) and fatal stroke (risk ratio of 1.82, 95%trusted interval 1.58 ~ 2.10) are relatively high. (figure 2).

figure 2

■ The risk of non -fatal strokes in the death of dead production is 31%higher (1.31, 1.10 to 1.57).

■ The risk of fatal strokes of recurrence of deaths is 26%(1.26, 1.15 to 1.39).

Explore

1

Infertility and Edge

★ Polycystic ovary syndrome and premature ovarian failure are two major ovarian diseases related to female infertility.

The risk of polycystic ovarian syndrome is related to the risk of insulin resistance, glucose intolerance, and increased state of increased thrombosis, which will lead to vascular dysfunction and long -term risk of stroke.

Premature ovarian failure is accompanied by the decrease in estrogen levels, and it will increase the risk of stroke through the loss of potential neuropromemics and anti -inflammatory characteristics through estrogen.

At the same time, in the cases of infertility caused by the two, the prevalence of thyroid self -immunity is higher, which will further increase the risk of ischemic stroke through thyroid atrial fibrillation and high -coagulation state.

★ In addition, infertile women are more likely to smoke, obesity, anxiety and depression, which will increase the risk of future stroke through smoking, insulin resistance, inflammation increase, and platelet agglomeration.

2

Abortion, death and stroke

★ The potential mechanism of stroke risks related to recurrence or death is endothelial dysfunction.

It may lead to loss of pregnancy through placenta -related defects, and continue to exist after complex pregnancy, and promote the development of stroke by reducing blood vessel diastolic and promoting the state of inflammation.

★ Anticin antibody may induce placental vascular thrombosis and cause miscarriage, causing stroke by inducing the state before the thrombosis.

The binding of anti -phospholipid antibody and endothelial cells causes normal endothelial anticoagulation dysfunction and promotes thrombosis, which will develop with the development of ischemic stroke.

★ Women with recurrent abortion are also more likely to have unhealthy behaviors (such as smoking), obesity and depression, which may lead to future stroke risks.

Capture: Wang Lu

Edit: Wang Lu

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