Hu Hailan won the Achievement Award for Outstanding Female Scientists in the World!Zhejiang Daily reporter interview

Zhejiang News Client reporter He Dongjian

Hu Hailan is "fire".

In the early morning of June 24th, UNESCO invited her to the Paris Ceremony in France, and awarded her "L'Oreal -UNESCO World Outstanding Female Scientist Achievement Award", known as the "Women's Nobel Prize in Science". This award Only 5 women around the world are awarded each year, and 6 Chinese scientists who have won this award are academicians of the Chinese Academy of Sciences.

She has a lot of aura -a professor at Zhejiang University School of Medicine, Executive Director of Zhejiang University Neuroscience Center, and Dean of the School of Brain Science and Brain Medicine at Zhejiang University. Three months ago, she had just won the title of March Eight Red Banner Model in 2021.

Today, the lively and halo flooded in front of the female scientist. She also admitted that she wanted to "do scientific research for a few years again", but she did not expect to be thrown into the spotlight at once.

"Although the mystery of the brain nerve has always been the" unsolved mystery ', I believe that one day, based on the understanding and cognition of the neural mechanism behind mental illness, humans can create solutions to get rid of pain for patients with mental illness. " Hu Hailan said at the awards ceremony.

Zhejiang News Client reporters connected with Hu Hailan video far away in Paris, and shared the joy of winning the prize, scientific curiosity and future expectations with her.

Paris trip

This is not Hu Hailan's first trip to Paris.

In the academic activities in Paris in the past, this female scientist always arranged for her time, watching drama, or watching exhibitions, or visiting famous monuments. Opportunities for collision. But this time she lamented that "the schedule is particularly full", and there is no time and opportunity to satisfy her artistic wishes.

Due to the epidemic, this year's awards ceremony has accumulated 15 female scientists who have accumulated three "Outstanding Female Scientists Achievements Award". The strongest brains from all fields in the world were warmly welcomed to Paris. In public reports, you can also see that the Chinese University of Education and Sciences in the United Nations A delegation in Paris will be held in Paris on the evening of the 21st local time to congratulate her to win the 2022 "World Outstanding Female Scientist Award".

"What I was impressed by this trip to Paris was to communicate with other female scientists." She said that there is a special link in the French Academy of Sciences. Every award -winning female scientist shared and exchanged their jobs to everyone, from New crown vaccines from embryonic development to data encryption, in extremely broad spans, scientists from all over the world enjoy this feast. Moreover, she got along with each other and "became a good friend" in these days. She also talked about the possibility of scientific cooperation. In the interview, she laughed that it was the "biggest harvest" of this trip.

For the gratitude of the French Academy of Sciences, Katarine Kobiro's thank you were very special. She said: "Others will thank students and post doctors, but in my 40 years of graduate career, none of them, nor did they have no students, no students, no students, no students, no students, no students, no students A postdoctoral, all the experiments were done by myself. "The scientist who became famous in the newly -crown MRNA vaccine told a story similar to Cinderella -most of her career was most time in her career. Various setbacks. In Katarine, he took a train to Budapest and won the third place in Hungary Biological Contest in his own elementary school. He was particularly interested and talented in biological aspects. But after working in the United States, for a long time, she spent in the cycle of "writing funding -was rejected", and even was fired by the school many times to find a job. At the age of 58, she went to a small company with only dozens of people in Germany alone. The company has now grown to 3,000. Everyone knows the later stories. In the research and development of the new crown MRNA vaccine, Carteline became famous.

"From Qatar's body, we see the toughness of scientists." Hu Hailan said that Qatar's story was unparalleled to herself. When chatting with Qatar, she could feel that she had always maintained "Little Little Little Small Little Little Small Little Small. Girl's childlike and persistence. " And this is the mystery of scientific success.

Science question

The word toughness, in our communication with Hu Hailan, repeatedly mentioned it.

In the field of scientific research, perseverance is not a metaphor, but a reality. There is an example. The mentor of her friend once said that if 50%of the test is expected, it should give up this subject because it is "not innovative enough."

Therefore, it is not difficult to understand that in the laboratory of the Zijin Port Campus of Zhejiang University, Hu Hailan is facing the failure of the experiment more than 70%of the time every day -or temporarily unsuccessful. As she said, "the exercise of toughness is also the basic skill of scientists."

After day after day, she never felt that scientific research was a boring thing. As the third place in the Zhejiang Physics Competition in the high school era, the school fighter sent to Peking University has an unusual interest in science. In her mouth, we can find the impact of the three teachers of Xu Chengnan, Hu Guo and He Dongtao of Hangzhou No. 2 Middle School on her scientific road. Read together to read a book to eat.

"In our opinion, scientists are the best occupations in the world. This is the country and social funding you, so that you can be a career that you are really interested in." So for this female scientist, she is interested in topics. It must be a relatively unacceptable field, the problem is interesting and important, and at the same time, it has potential social significance. During college, read a book called "From Neuron to the Brain". Intersection She was suddenly cheerful and could be said to find the way forward in the future. There is a question on Zhihu, called "What is the experience of Mr. Hu Hailan's graduate student?"

An anonymous student used a keyword to describe- "Happiness".

Teacher Hu is the most admirable among people I can contact in my life. I admire her not because of her achievements, but because of the work of working with her and receiving her guidance, her work is diligent, the attitude of being improvised, and treating the scientific research is not good. The curiosity of new knowledge and her self -discipline in life. What Teacher Hu gave me may surpass what she thought she thought. In addition to giving me a bright beginning on the road of scientific research, more importantly, she gave me the courage, confidence, and methods that gave me on this road. I have witnessed the development process of our laboratory from the first article to so many articles and so many topics. Mr. Hu made the progress of these topics in a very elegant way. I learned too much in the process. I believe that every student of Mr. Hu grows up very land in the process of working with Teacher Hu.

Scientific research has its own laws and time, and sometimes it may make breakthroughs at once, but many times it is very long. So "Scientific research is like the marathon that does not know where the end point is. You have to adjust your own rhythm. Sometimes it is fast, sometimes slow, sometimes a companion together, and sometimes it is alone. The charm, but always makes you hopeful. "Hu Hailan was doing this, and told students so.

Worldwide problem

The public's deepest impression of Hu Hailan may be that in 2018, she and her team published two long articles in the same period on the international journal "Nature", revealing the mechanism of fast antidepressant molecules, which provided the development of new antidepressants of antidepressants. Many new molecular targets, some scientists commented that the study "breaks the world's problems".

More than a decade ago, the clinicians of Yale University have discovered the curative effect of ketamine's conjunction of depression, and scientists around the world are understanding how it plays a role and why it works so quickly.

The Hu Hailan team analyzed the mechanism of depression itself through the research of ketamine in 2018.

"We found that there is a small nuclear group in the brain. This nuclear group is very small, but it plays a very large role in the medium negative emotions. We also call it the" anti -reward center "of the brain center." It is said that the team found that in the state of depression, the activities in this small nuclear group were abnormal, or they entered a particularly high discharge state. The excessive activation of such a "anti -reward center" is the consequence of excessive suppression of the brain reward center, and the reward center is the source of nuclear pleasure, heart pleasure, and the source of reward experience related chemicals. Essence So this may be the reason why people enter the state of depression.

At the same time, the team also found that the reason why ketamone is so fast because it can quickly block the excessive discharge or excessive activation state of the "anti -reward center", thereby playing a switch. "The excessive suppression of the" reward center "play a role in quickly suppressing depression. In the process, the team also discovered two or three new different molecular targets, which can be used as the target of potential antidepressants.

"One of the important significance of our basic research is to find that ketamine is not the only choice." She said, so the team's current research related to the application is two, one is to cooperate with other laboratories at home and abroad, hoping to have ketamine in the ketamine in the domestic and foreign laboratories, hoping to have ketamine in the domestic and foreign laboratory. The molecular structure is transformed to retain its anti -depression, remove its addiction, or other side effects. The second direction is the expansion of the target. At least one molecular target and the target of ketamine are played in the same path.

"We predict that after blocking this target, we will also have the effect of antidepressing. In response to this target, there are already drug treatment of other diseases in clinical practice. We have started cooperating with the clinical team two or three years ago. The idea to treat depression, "she said.

Bird according to female scientists

The master of Hangzhou Innocence Book Book, Zhu Jinxiu, wrote an article called "Birds according to the female scientist".

The protagonist in the article is Hu Hailan. In the art of the article, she usually takes the parrot she raised to sit, and even some papers are completed in the lake and mountains of Gem Himmos.

"My first impression of Hai Lan, I feel that she is a beautiful, innocent, and good next door." Zhu Jinxiu said that she first met Hu Hailan.

In fact, before others introduced them, Hu Hailan had patronized the book for many years. Every time she likes to sit by the window on the second floor, enjoy the breeze blowing from the West Lake, and silently write an article. "She is gentle and beautiful, tall, elegant and elegant, sitting in front of the window, just integrated with the West Lake outside the window." Zhu Jinxiu said, "Every time she comes, we will not disturb, and I always think she is like she is. A guest who likes books. "Until one day, Zhu Jinxiu's old friend He Dongtao came to the book to introduce her to her proud students. Intersection Zhu Jinxiu said that He Dongtao was once the class teacher of Hu Hailan's high school. Now he is the president of the Hangzhou Fourteenth Middle School Education Group. Although the students have graduated for more than 20 years, the relationship between teachers and students has always been very good. sit.

"Some days they came together as usual, but President He had something to do with it, so Hai Lan came with her classmates." Zhu Jinxiu said that they wrote their own work content, just like high school in high school, just like high school in high school when they were in high school when they were in high school. Good students to do homework together. Hai Lan was also happy to share with her an article just written in the book bar. At that time, there was a small partner who recognized Hu Hailan. She also said that many of her scientific articles were completed in the book bar.

Zhu Jinxiu once asked her curiously. Other scientists usually write articles at home or office. Why do she like to come to book? Hu Hailan said that here can not only overlook the West Lake, but also feel the strong scent of books, coupled with the fresh air, "Wen Si is like a spring."

In addition to scientific research, the female scientist also has her own "small worries". "She has a sticky parrot." Zhu Jinxiu said, the little parrot flew to Hailan's house last year. At that time, when I saw this little guy's feathers seriously, it adopted it. Later, I learned that it suffered from feather pecking and often pecked its feathers. So Hai Lan has often brought it to see a doctor for more than a year, but the effect is not very good. After that, whether it is going to work or playing, or going to a book, it will take it. The little parrot is also very good, always obedient to Hailan's shoulders. "We helped Hai Lan think about a way to knit a sweater for the parrot so that it can't peck his feathers. I guess now that Hai Lan is already preparing for clothes for her birds!" Zhu Jinxiu Say happily.

In the spring breeze, on the West Lake, listening to the story of scientists and a bookstore, a small parrot, landscape and people, so harmonious.

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