Professor Harbin Institute of Technology revealed the molecular mechanism of the human B -cell receptor complexal assembly

Xinhua News Agency, Harbin, August 19 (Reporter Yang Siqi) Reporter learned from Harbin University of Technology on the 19th that Huang Zhiwei, a professor of the school's life science center, released the latest research results, revealing the assembly and identification of the human B -cell receptor complexion The mechanism also found that different subtype B cell receptors have different assembly modes.

T cells and B cells are human adaptive immune cells, which plays a key role in pathogenic infection, cancer, and autoimmune diseases. They identify the antigen signal through T cell receptors and B cell receptors, and pass the signal to the cells to activate the immune response of T cells and B cells. However, the structural foundation and molecular mechanism of its receptor complexes and immune activation have always been an important basic scientific issue in the field of immunology.

Human B cell receptor has 5 subtypes. This research team analyzes the structure of B -cell receptor complexes of the human body IGG and IGM subtype. Studies have found that the B -cell receptor complex structure contains an immunoglobulin homologous diodes in forms of membrane binding, which is used to identify the antigen and an heterogeneous di -gymnarian in form. A series of experimental data not only analyzes the unsolved B -cell receptor structure and assembly mechanism that has not been cracked for a long time, but also provides the molecular mechanism that recognizes its immune response, and the development of immunotherapy for the development of B cell receptors for treatment of related diseases. Key structural foundation.

This paper was published in the "Science" magazine on the 18th, entitled "The Frozen Electronics Structure of Two Sub -Human B C cell receptors". During the same period, the magazine published a comment article in the "Viewpoint" column, saying that the study revealed the path of the B -cell receptor structure, the molecular structure, and provided a path for understanding and controlling B cell receptor activity.

In recent years, in terms of the structure and molecular mechanism of human immune cell receptors, Huang Zhiwei's research team has solved a series of technical problems, including analyzing the three -dimensional structure of human T cell receptor complexes, and revealing the subtype of the sub -cell receptor complex. The assembly and identification mechanism proposes the "cholesterol -door embolism" control theory of T cell receptor, which provides theoretical basis for designing immunotherapy for T -cell receptors to regulate T cell activity.

It is reported that this project has been funded by funds such as the National Natural Science Foundation of China and a youth scientist studio in Harbin Institute of Technology.

[Editor in charge: Xue Tao]

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