The first domestic freezing melting ovarian tissue is transplanted in Guangdong to complete

"Mom, I seem to be menstruation ..." "That's really great!" The ordinary conversation is a twists and turns behind it.

It is reported that Xiaoxiao (pseudonym) was diagnosed with severe thalassemia. In 2019, Professor Liang Xiaoyan, the chief expert of the Narcotic Newborn Department of the Sixth Hospital of Zhongshan University and Professor Liang Xiaoyan in the Reproductive Medicine Center, formulated a bold treatment plan for her -in order to retain Xiaoxiao's fertility in the process of putting and chemotherapy Before the treatment of stem cell transplantation, preserve some of her ovarian tissue and mature ovarian female cells in vitro. After the transplantation is successful, the frozen ovarian tissue is transplanted back to her body, allowing Xiaoxiao to restore the ovarian function and start puberty development.

Recently, the 16 -year -old Xiaoxiao finally had the first menstrual period after she accepted the transplantation of hematopoietic stem cells, and her fertility preservation was greatly successful. It is understood that this is the first domestic case of adolescent severe thaladon tissue in the pelvic transplantation of autologous frozen ovarian tissues in the first time in the country. It is also the most old -age autologous ovarian tissue in China to thaw transplantation after freezing.

Severe thalassemia, traditional therapy may lose fertility

According to reports, Xiaoxiao diagnosed severe β thalassemia after birth, and blood transfusion and iron discharge can be maintained to maintain normal life. This allows the thin Xiaoxiao to be accompanied by the hospital for a long time.

In 2019, Xiaoxiao was 14 years old, but he was only 1.48m tall. The growth and development indicators were far lower than the normal level of children of the same age. In order to allow her to live a normal child, Xiaoxiao's parents decided to accept the blood specialist and propose to let go to carry out hematopoietic stem cell transplantation. This is currently the only way to effectively cure severe Mediterranean anemia.

It is reported that the treatment of hematopoietic stem cell transplantation needs to be released and chemotherapy. It will cause devastating damage to ovarian function, which will allow patients to no longer have menstrual cramps.

In order to seek a better treatment plan, in 2019, Professor Liang Xiaoyan and Dr. Li Jingjie's outpatient clinic of the Xiaoxiao family went to the 6th Hospital of Sun Yat -sen University to seek medical treatment. After the fine fertility assessment, Professor Liang Xiaoyan's team boldly innovated to formulate a advanced fertility preservation plan for Xiaoxiao -that is, before the treatment of hematopoietic stem cell transplantation of Xiaoxiao, she preserved some of her ovarian tissue and in vitro mature eggs Mother cells. After the hematopoietic stem cell transplantation is successful, choose the appropriate time to transplant the frozen ovarian tissue back to the body, allow Xiaoxiao to restore the ovarian function and start puberty development.

"This may be the first case in China, but please rest assured that we have experience in the ovarian tissue and thawing transplantation." Liang Xiaoyan soothed. As a result, the "fertility preservation journey" belonging to Xiaoxiao began!

The ovarian frozen preservation, successful "restarting" development after 3 years

In November 2019, Liang Xiaoyan's team joined the president of Wang Dejuan, a pediatric surgeon in the hospital, and successfully took off the ovaries of Xiaoxiao under the laparoscopy of children. For 11 pieces of organizations, freezing through strict operating processes, 9 mature eggs that have been shedding are placed in a special egg nutrient solution.

In December 2019, Xiaoxiao completed hematopoietic stem cell transplantation, and there was no need to maintain his life through blood transfusion after surgery. However, the re -diagnosis was evaluated. The results showed that Xiaoxiao's ovarian function was completely exhausted, which is equivalent to the female ovaries of the menopausal period. The growth and development of children lags behind their peers.

The timeline came to January 20, 2022. It has been nearly three years after the 16 -year -old Xiaoxiao's hematopoietic stem cell transplantation. Her natural adolescent development plan restarted again. After the Liang Xiaoyan's team was closely planned, the surgery lasted only an hour for Xiaoxiao's pelvic cavity. After the surgery, Xiao Xiao was discharged smoothly under the close monitoring of the medical team.

It is exciting that the results of the five months after surgery show that Xiaoxiao's ovarian function has begun to recover, sex hormones have resumed normal levels, and imaging examinations have found that Xiaoxiao's uterus and breasts have begun to increase development, indicating that transplantation is reminded Ovarian tissue has survived, and Xiaoxiao has begun to restore natural adolescence. For the first time in life, there was a wave of menstruation, which proved that Xiaoxiao's "fertility preservation journey" was a great success. The center team realized the transplantation of ovarian leather to survive in Xiaoxiao's body.

Xiao Xiao's parents cried very much. They held the hands of Liang Xiaoyan and the doctors tightly one by one, and thanked the doctors for helping you! Let Xiaoxiao grow like normal children in the future! "

The treatment of blood tumors that account for 70%of the incidence of children's tumors, ushered in a new dawn

Professor Liang Xiaoyan introduced that in the two and Guangxi regions of my country, Mediterranean anemia is one of the most common local diseases, which seriously affects the health and development of children with sick children.

Treatment of thalassemia, chemotherapy treatment, or bone marrow transplantation, but about 70%to 90%of children's reproductive endocrine function after treatment will be irreversible. In addition, according to the data of the National Cancer Center in 2020, children's tumors are increasing at a rate of 2.8%per year, most of which are hematological tumors, such as leukemia and lymphoma, accounting for 70%of all child tumors. There are also loss of ovarian or testicular function after tumor cure.

Professor Liang Xiaoyan pointed out that before the transplantation of autologous frozen ovarian tissues, there are currently no successful cases of children in children in China.This complete fertility preservation and repair laboratory and surgery system experienced by Xiaoxiao prove that the ovarian function can be properly retained, marking the level of surgical treatment of domestic children's fertility preservation and self -frozen ovarian tissue transplantation.The last step indicates the emergence of the "new" path for the treatment of children and youth's blood diseases.(Guangming Daily All -Media Reporter Wang Zhongyao Correspondent Jian Wenyang Dai Xi'an)

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