Nephrine Health Online | Objectives of analgesic, be careful of kidney damage!

Author:Guangdong Provincial Hospital Time:2022.06.13

One day, a young man named Xiao Li came from the clinic. He found a problem with the kidney function during the physical examination of the unit. At first glance, creatinine: 109umol/L. He asked the doctor casually: "It's just a little higher, don't it matter?" The doctor told him that once the creatinine increased, it often meant that the renal function was more than half of the damage, and the specific damage had to be further evaluated. Xiao Li was frightened. He thought that the creatinine was a bit unrelated, but he did not expect to prompt such a serious problem. By asking the medical history, the doctor learned that Xiao Li had had joint pain before, but there was no regular treatment. When the joint pain took a few slices of painkillers, the pain was not cared for a few years.

Doctors told Xiao Li that the most common painkillers to treat joint pain are non -steroidal anti -inflammatory drugs. Non -steroidal anti -inflammatory drugs are one of the most common types of drugs to control various arthritis. This drug is a big family, ibuprofen, Puzukon, Mihlin, Moroccan, Saisi, and relying on Coscorns, etc., all belong to non -steroidal anti -inflammatory drugs. Non -steroidal anti -inflammatory drugs are widely used in clinical practice, which can not only effectively alleviate the pain of arthritis, but also have the effect of inhibiting body inflammatory response. However There is also a side effect that is not well known -kidney injury risk.

The kidney is an important organ for metabolic chemicals and various drugs to discharge metabolites. The foods and drugs ingested daily need to pass the kidneys from in vitro. Therefore, kidney is also the main target organ for drug injury. With the widespread use of various drugs and even abuse, the damage of the drug to the human body and various side effects are becoming more and more obvious, and the increasing kidney damage caused by it. Drug kidney damage can be mild, reversible, or may develop into severe kidney damage.

Which drugs can easily cause kidney injury?

1. Antibiotics and other chemotherapy drugs:

① Frequent damage: Biseomycin B, texycin, cephalomycin Ⅱ, etc.;

② More often damage categories: galcinin, scatomycin, splinycin, metamycin, butanaminicoin, polyphino, vanomycin, sulfa drugs, etc.;

③ Occasionally see damage: new penicillin (Ⅰ, Ⅱ, Ⅲ), ammonia and other penicillin, carboxylinininin, ristomycin, 土mithromycin, cephalosporidin (ⅳ, ⅵ, ⅵ), Lifupin, ethylamine tanninine, ethypsin, Alcohol, etc.

2. Non -steroidal anti -inflammatory analgesic drugs: anti -pain, ibuprofen, Paitatong, pain Xikang, aspirin, compound aspirin, Feinidine, aminobilin, heating polygal, hydraulic and oxygen萘 acid and so on.

3. Tumor chemotherapy drugs: cisplatin, methotrexate, glorious glowing, fillerticillin -c, nitrobilin, 5-fluorophiline, etc.

4. Antilateral epilepsy: triterone, sodium benzyetal, etc.

5. Anesthesia: ether, methaxane, etc.

6. Metal and complexing agents: penicilline, acid salt, etc.

7. Various vascular creation agents.

8. Other: Histycin A, methyl cyanopylin, nubbinol, mannitol, mercury Satrin, heroin, low -molecular right waifs, etc.

9. Renalized Chinese herbal medicine

It is worth noting that in the absence of improperly or overwhelmed, some Chinese herbal medicines can also cause damage to organs such as liver, kidney, and digestive tract, such as Guanmutong, Guangfang Ji, Qingsi, Macao containing aristolochic acid, Bells, Tianxian Teng, etc., as well as Chinese herbal medicines such as cinnabar and cream. Chinese herbs such as spotted, crickets, beex, and other animals also have certain kidney toxicity.

Who is prone to medicinal renal injuries?

1. Elderly. The elderly may have a decrease in renal functional reserves; combined with multiple diseases (such as diabetes, atherosclerosis, hypertension, etc.).

2. Those with chronic kidney disease or kidney dysfunction.

3. Insufficient kidney blood flow or poor blood flow.

4. Those who use multiple drugs at the same time because complex or chronic diseases. It is usually found in patients with major surgery, organ transplantation and intensive care unit.

How to prevent medicinal kidney damage?

1. Do not abuse the so -called "ancestral secret recipes" and folk recipes. If you must use a certain prescription or medicine, you should obtain its formula or component first. After consulting the specialist, you should consider the use of kidney safety.

2. Drink more water before taking the medicine to ensure enough urine to promote drug excretion and reduce its effect on renal toxicity.

3. Drugs that are known to have renal toxicity or unknown pharmacological effects, but must be used, and need to closely observe the changes in urine and renal function when used, discover abnormalities as soon as possible, and stop the drug in time.

4. People at different ages should pay attention to drug renal toxicity, especially the elderly and children. They should be particularly cautious about the choice of drug types and dosage.

5. Most of the chronic renal damage of the drugs is caused by long -term or excessive medication. The medication must be strictly observed. Do not increase the dose and extend the time of medication.

6. Long -term medication should be resumed. Patients with long -term medication should follow the doctor's advice regularly. Not only can it observe the efficacy of the drug, but also to avoid certain adverse reactions in time. Regular reviews related to drugs include blood routine, liver function, kidney function and other examinations. If you feel unwell during the medication, you should communicate with the doctor in time to avoid serious consequences.

What should I do if a drug -based kidney injury occurs?

The treatment timing and treatment measures for medicinal renal injuries have an important impact on the prognosis. Generally speaking, if it can be treated in time and correctly, most pharmaceutical renal damage patients can turn in danger and even the renal function. When abnormal amounts, less urine, no urine, hematuria, proteinuria, increasing nighturia, edema and other symptoms, we must be alert to kidney damage caused by drugs. You should choose a special hospital for a regular hospital for diagnosis and treatment as soon as possible. Medical Guidance:

Liu Xusheng

Chief physician, professor, director of the Department of Nephrology, Guangdong Provincial Hospital of Traditional Chinese Medicine, Discipline Leader, Doctoral Tutor, Postdoctoral Cooperation Professor, head of key diseases (chronic kidney disease) at the National Chinese Medicine Research Base The person in charge of the center, the second batch of old Chinese medicine academic heirs in the country, and the second hundred outstanding youth traditional Chinese medicine in the country.

He is currently the deputy chairman of the kidney disease branch of the Chinese Medicine Society, deputy chairman of the Professional Committee of Kidney Disease Prevention and Control of the Chinese Association of Prevention and Medicine, Deputy Chairman of the Children's Society of Chinese Medicine Society, President of the Nephrology Branch of the Chinese National Medicine Society, China Industry, Scholar Research Research Research The chairman of the Promotion Association of TCM Nephrology Prevention and Control, Chairman of the Commission of Nephrology of the General Society of the Traditional Chinese and Western Medicine Society, and chairman of the Commissioner of the Slow Disease Management Professional Committee of the Guangdong Provincial Society of Traditional Chinese Medicine.

Good at: chronic nephritis, nephropathy syndrome, acute, chronic renal failure, hypertension nephropathy, diabetic nephropathy, lupus nephritis, etc.; Chinese medicine combined with hemodialysis and peritoneal dialysis to treat uremia.

Supply: Jiecina Department