Alzheimer's disease: inevitable absence

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The following is the audio of the full text of Miss Sister

Author | Sylvia R. Karasu

Translation | Caroline

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Reading | Pigeon Tsai

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1. Alzheimer's disease is a type of neurodegenerative disease, which affects the memory, cognition, personality, and behavior of more than 24 million people around the world.

2. People with type 2 diabetes have higher risk of Alzheimer's disease, which is sometimes called type 3 diabetes. 3. So far, it has not been effectively targeted at Alzheimer's disease, but researchers are re -utilizing drugs such as dual -dual -dual -duality, hoping to prevent this inevitable process.

"For someone who loves, isn't the absence of the most certain ... the most lasting, most uninterrupted ... exist"?

--- Pruuster, "Happy and Life"

When Emi Bloom described her cognitive ability of her architect husband, Prurst's words could best resonate with her. In the book "Memoirs of Love and Lost" (2022), the description of her cognitive ability of her architect husband's cognitive ability is moving. Bloom wrote: "Sometimes with Bryin, I am more uncomfortable than a person because I disappear from his world." The book was beautifully recorded that her husband chose to commit suicide after being diagnosed with Alzheimer's disease (AD).

Alzheimer's disease is a "dependent nerve degenerative disease that depends on age" and is the most common cause of dementia. It affects 24 million people around the world, two -thirds of which are women, which are characterized by the decline in memory, cognitive power, and changes in behavior and personality.

Researchers conducted many years of research on Alzheimer's disease that were first discovered more than a century ago. We know that its pathology, that is, β-starch-like protein plaques and nerve fiber tangles, as well as neuritis and atrophy in the brain after death. We even know that these changes will appear decades before the surveyed cognitive disorders. But not all researchers agree that these processes have causal relationships or are just related.

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Burum said: "No one seems to know what they should do." Literally, there is no treatment method. The most advanced Alzheimer's disease in the world said that eating a lot of blueberries and getting a lot of sleep.

Bloom is correct: So far, "there is no precise and effective treatment strategy" to reverse this disease. This is not because of lack of attempts.

Some researchers, such as neurologists at the New York Presbyterian Hospital (Will Cornell Medical College), and Richard Azaxeson, director of the Aldzheimer Disease Prevention Clinic, believed that comprehensive assessment and very early intervention, including diet, The change of lifestyle may be the key to interfere with Alzheimer's disease inevitable progress.

Although these changes may be hopeful for some people, so far, no drug has been proven to have clinical effects. However, in the process of searching, researchers have shifted their attention to re -utilizing the existing drugs in the market.

The two -metal duality is one of the most common prescription medicines in the world. As a first -line treatment drug for type 2 diabetes, it has shown potential in aging research, especially for Alzheimer's disease. Unfortunately, research sometimes leads to contradictory results.

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For example, in an anterior clinical study about rodents, the two -metammer did not bring any benefits of extending life or reduce the content of insulin or glucose like previous research, which made Allison and their colleagues speculate that they had a department of rats. Choosing may lead to their disappointment.

In addition, although there are a large number of literature on many different health results, Ioannidis et al. On the "total" retrospective discovery of more than 425 different fate analysis (including random control test (RCTS) and observation report). Study "low quality or extremely poor", even "basically unreliable". These investigators found a considerable heterogeneity between the research, and most RCTs did not even provide information about the dose of dual -dual -dual -dual -dual -dual -dual -dual -dual doses of the follow -up time or used. Potential conflicts of interest are often not explicitly pointed out.

However, why do researchers consider using Erjia and Shuangya in the study of Alzheimer's disease?

The answer is that "convincing evidence" indicates that Alzheimer's disease can be considered a metabolic disease. In some studies, 80%of the subjects with Alzheimer's disease have insulin resistance or Type 2 diabetes, those patients with type 2 diabetes have higher risk of onset of Alzheimer's disease.

Some people even think that this is not just a metabolic disease, but type 3 diabetes. The connection between Alzheimer's disease and type 2 diabetes "does not have a clear conclusion", but their "similar pathogenesis" has triggered a lot of research, and the impact of drugs such as dual -dual -dual -duality on Alzheimer's disease.

Tame: Targeting with Metformin is used to use the two -blind placebo. At present, this study is recruiting thousands of subjects. Its task is to create a "paradigm" to evaluate the pharmacological methods of delaying aging diseases, including Alzheimer's disease, and adding "healthy spans", that is, the life of "relatively no disease". Two -dual -dual -two -choice of drugs, because it has a good security record and "new evidence", it may "protect cognitive functions." Some evidence shows that the dual -dual -dual -dual -dual -dual -dual -dual -dual -dual -duplex patients with type 2 diabetes suffer from Alzheimer's disease. In addition, the anti -inflammatory and anti -oxidant special mechanisms, as well as other mechanisms, showed a constructive reason for these patients.

Not all research agrees this view, usually because the length of the research crowd, dose, and contact with the dual -two dual -dual -dual -dual -dual -dual -dual -dual -dual -dual -dual -dual -dual -dual -dual -dual -dual -dual -duplex period, and the subject's APOE4 (a potential genetic mark developed by Alzheimer's disease), different carrying status Essence

For example, a system review and facky analysis including diabetic patients and non -diabetic patients (4 control tests and 24 observation studies), which include diabetes and non -diabetic patients, cannot confirm its beneficial role in improving cognition or preventing Alzheimer's disease. Although the researchers admit that their discovery is "not conclusive."

Some studies have also shown that the dual -two dual -dual -dual -crickets may be good for those who cognitive normal, especially if they do not have the genetic mark of APOE4. However, once Alzheimer's cognitive obstacles occur, the two -metal dual -dual -dual -dual -dual -dual -dual -dual -dual -dual -dual -dual -dual -dual -dual -dual -dual -dual -dual -dual -dual -dual -dual -duplex may no longer have a protective effect.

In general, the treatment of Alzheimer's disease was still quite controversial and contradictory. Therefore, many researchers urged to act with caution and suggest that they adopt "personalized accurate methods", because the role of Twita doubles in the treatment of Alzheimer's disease has not reached a consensus.

However, in this case, clinicians seem to agree that we should continue to eat our blueberries.

Via: Marianna Kulukundis

Reference (click slide to view)

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