The first case in the country!Parents donate 1 kidney to save twin daughters

Wuhan Evening News June 29 (Reporter Li Qing Correspondent Ning Yafei) The twin sisters of Jiangxi 18 -year -old were unfortunately diagnosed with renal failure and life was dying. Parents resolutely decided that one person donated a kidney, as long as the daughter lived. In April and June of this year, Professor Zhou Jiangqiao, director of the Department of Organ Transplantation, People's Hospital of Wuhan University (Hubei Provincial People's Hospital), led the transplant team and successfully performed live relative kidney transplant surgery twice. According to the retrieval, parents donated their kidneys to save their twin daughters. The first case in China was reported in the world. Before, there were only one report in the world in the world.

A family of four took a photo with the doctor.

rare:

Twin twins are also suffering from kidney failure

In 2003, Ms. Hu, 28, Ganzhou, Jiangxi gave birth to a pair of twin daughters. Since then, the husband and wife have made money to raise two well -behaved daughters. Although the family of four is not rich, she is happy.

In July 2021, unfortunately followed. Sister Xiaoyi (pseudonym) has symptoms such as foot pain, anemia, fatigue, and loss of appetite. Soon after, her sister Xiaoru (pseudonym) appeared in similar symptoms such as colds, dizziness, and weakness. The bizarre is: the symptoms of the two people have a high symptoms, and they have become ill at the same time, and the treatment of drugs has not improved for many days.

"Usually it has always been good, and suddenly vomit is very scary, so I almost spit out my stomach." The parents took the sisters to the local hospital for treatment. Examination found that the kidney function hemophilia is about 560umol/L. It has symptoms of anemia. Both were diagnosed with uremia (stage 5 of chronic nephropathy) and 3 levels of hypertension (extremely high risk).

"Suddenly it feels like the sky is." Parents who, who, who suffered from the thunderbolt, felt incredible: What is the cause of the twin sisters in the same period? After one month of hard verification, the genetic testing report tips: NPHP1 gene mutations lead to renal failure of twin sisters.

After 3 months of peritoneal dialysis treatment, the condition of the sisters has eased, but the condition has seriously affected normal life. "Daughter and kindergarten have graduated, they are about to go to work, and they will still be married in the future. This will delay their lives." In December 2021, parents took their daughters to the organ transplantation department of Wuhan University People's Hospital for seeking help.

Professor Zhou Jiangqiao, Director of the Department of Organ Transplantation, pointed out that kidney units are a cystic kidney disease with recessive inheritance of autosomal chromosomal. The disease is mainly on the childhood. , Anemia, renal failure, etc., the urine test is basically normal or slightly abnormal, and most of them have developed into end -end renal diseases. Due to renal failure, there is no obvious clinical manifestation, and it is difficult to diagnose in time in the early days. Many patients have developed into chronic renal failure while medical treatment.

hope:

Cross -blooded kidney transplantation technology

Seeing the weakening of the daughters, parents' hearts are like a knife. A family completes organ transplantation registration at the Department of Organ Transplantation at the People's Hospital of Wuhan University, waiting for kidney transplantation opportunities. For more than 2 months of anxiety waiting, there is still no news.

In the daily exchanges close to Associate Professor Qiu Tao with the Department of Organ Transplantation, they learned that the inter -kidnal transplantation of relatives can not only reduce the economic burden, but also shorten the waiting time to treat the condition as soon as possible; at the same time The possibility of heterogeneous and other complications is also lower than that of the alien kidney transplantation of the bloodless relationship. Parents resolutely decided to donate their kidneys to their daughters.

Zhou Jiangqiao introduced that the living relative relative kidney transplantation of the "Family Mutual Aid Self -help" model is a better way to choose from some patients with nephropathy in my country, but there are also many gates to "break".

Medical ethics review is the first level of relatives' kidney transplantation. The organ transplantation section demonstrates the feasibility and safety of the living transplantation solution based on the results of the genetic testing and the clinical symptoms of the disease of a family of 4 people: 2 daughters have caused kidney failure due to the development of the kidneys itself, while the parents' kidney structure and function have no functions. The problem, at the same time, the daughter's body is in good environment, and the healthy kidneys will not have problems such as kidney disease. After several rounds of research, the Ethics Commission reviewed the final audit and passed the live transplantation plan.

The problem of cross -blood kidney transplantation followed. The matching results show that Ms. Hu is a Blood of B, and a pair of daughters are type A blood. In the past, such different blood type had a high chance of rejection of rejection. Through years of technical accumulation, Wuhan University People's Hospital Organ Transplantation Department, which has the implementation of cross -blood -type kidney transplantation mature technology, can carry out ABO blood type incompatible relatives for kidney transplantation (commonly known as cross -blood kidney transplantation). Technical problems are solved.

Director Zhou Jiangqiao's inspection and wound examination.

Waiting for transplantation risks continuously. The little daughter Xiaoyi's peritoneal dialysis effect was poor, and her body was severe edema. She once had heart failure and chest water symptoms. She was urgently sent to the hospital in the hospital for treatment. The expert team adjusted the dialysis scheme, changed the abdominal transparency to the hemorrhage, and drained the chest water through puncture, and the symptoms were eased after the series of treatment.

Considering that Xiaoyi's pre -storage of group reactive antibodies for her mother, the expert team suggested to donate Ms. Hu's kidneys to her eldest daughter Xiaoru, and Xiaoyi accepted her father Liu donated the kidneys.

success:

Two kidneys successfully transplanted

According to the surgical plan, Ms. Hu and the eldest daughter Xiaoru first performed kidney transplant surgery. Mr. Liu, who came to the hospital to accompany, decided to bring his younger daughter beside him. "The family must always be neat."

According to Zhou Jiangqiao, the implementation of cross -blood kidney transplantation needs to be treated for a period of time to remove the blood -type antibody in the receptor Xiaoru's body, meet the blood type antibody titer standard to meet the surgery requirements, and then transplant the healthy kidney to the mother to the kidneys to Daughter in the body. The expert team is undergoing kidney transplant surgery.

On April 19 this year, the mother and daughter relative kidney transplantation was carried out as scheduled. Qiu Tao first performed left kidney cutting surgery for laparoscopy for his mother. Then Zhou Jiangqiao implanted this healthy kidney into Xiaoru's body. It took only 2 hours to transplant surgery to complete. Democratic. The daughter's transplantation of the kidneys is well running, and the mother's body is not a big deal.

Seeing that his wife and the eldest daughter had a good operation, Mr. Liu couldn't wait to donate his kidneys to the little daughter with a heavier condition. In accordance with the transfer of transplant surgery, under the circumstances of the left and right renal GFR (glomerular filtration rate) of the body, due to the long left renal vein and the convenient surgery, the difficulty of subsequent operations should be given priority to transplant the left kidney. However, considering that the little daughter Xiao Yi is lighter, the lower right kidney with a lower GFR GFR can meet her daughter's life needs, and at the same time, she can better ensure the health status of the father's father's later period. Professor Zhou Jiangqiao led the transplant team to decide to avoid it. It was difficult to choose the right kidney for transplantation.

On June 21, the absence of kidney transplantation of father and daughter began. Qiu Tao first obtained the right kidney under the laparoscopy and extended the shorter right renal vein of the original shortage, effectively reducing the difficulty of subsequent operations. Under the skilled surgical operation of Professor Zhoujiangqiao, the kidney transplantation surgery between father and daughter was successfully completed.

The recovery of my sister after surgery is good.

"Thanks to the parents and the medical staff of the organ transplantation department! 18 years ago, the parents gave us the first life. Now when we are in an adult, our parents and doctors and nurses have given us the second time. Parents, return to society. "Xiaoru and Xiao Yi, who had been reunited with their new life, were so excited.

Ms. Hu introduced with tears that in order to save the life of the two daughters, the entire family was working hard. Before the mother and daughter changed their kidneys, the husband got up early and running a tricycle to help people pull the goods to make money; the elderly parents saved money to save money for the granddaughter every day. The brother and sister's family did not spare no effort to help. "The road of their lives has just begun! As long as the children can get better, I can do it." Ms. Hu said.

[Edit: Yu Lina]

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