Patients produce antibodies due to long -term infusion of platelets, and the staff is "precise blood transfusion" through genetic modeling

Wuhan Evening News, June 27th News The 80 -year -old recycled anemia Patients with antibodies caused by long -term infusion of platelets, and the treatment effect is getting worse and worse. The blood transfusion research room in Wuhan's blood center finds a combination of platelets for them to make the patient's condition. Quickly stabilize. Yesterday, the patient's family sent a banner embroidered with a "guarding life with science and passing love with dedication" to the Wuhan Blood Center's blood transfusion research room.

Mr. Cai gave the banner to the blood transfusion research room of Wuhan's blood center. Correspondent Xiao Lijiao Photo

Through the genetic type, the staff finds a suitable platelet for the patient

In March last year, Grandma Li, 81, confirmed the regenerative disorder anemia and needed regular infusion of platelet supplementary treatment. Since May this year, patients have produced platelet antibodies in the body, the effect of infusion of platelets is getting worse and worse, the interval between the infusion is becoming shorter and shorter, and even the infusion is completely invalid.

The staff is conducting platelet HLA genetic types. Correspondent Xiao Lijiao Photo

Under the advice of clinicians, Grandma Li came to Wuhan blood center to apply for platelet gene matching. After receiving the application, the staff of the Wuhan Hematology Center's blood transfusion research room immediately conducted platelet genetic typing experiments on the patient's blood specimen. By comparing the platelet gene database, several blood donors were found to be combined with the platelet gene of the patient. Mr. Wang was among them. one.

Mr. Wang, 51, is an employee of the power supply company and a fixed blood donor. Knowing that his platelet gene was successfully matched with a patient, Mr. Wang actively responded and came to donate platelets to Grandma Li. Since May of this year, Grandma Li has infused platelets that matched her genetic phase 5 consecutive times in a row. The platelet count has increased rapidly, and the condition has quickly stabilized.

"Thanks to the Blood Center of Wuhan for finding the platelets that match their mother's genes, and thanks to the selfless contribution of blood donors for free!" A few days ago, Grandma Li's son, Mr. Cai, sent a banner to the blood transfusion research room of Wuhan blood center. He said that he would join the team of ingredients to contribute to the society with actual actions.

Wuhan built a platelet gene database, 1516 volunteers are regularly "blood transfusion"

"In order to allow patients to use the platelets that match the genes, Wuhan Blood Center has established the only platelet gene database in the province." Shen Gang, director of the blood transfusion research office of Wuhan Hemorrhea Center, said that the staff will fix the blood sample DNA of the donor donor for long -term low temperature Save, build their HLA and HPA genotypes into databases to provide information for patients' platelet matching.

Patients only need to contact Wuhan blood center through the department or blood transfusion department, and the blood center will perform HLA and HPA gene -class types of platelets on the blood center, and search for blood donors that match them in the platelet gene database to provide reliable guarantee for clinical precise blood transfusion Essence

Since 2019, the center has been screened and established 1516 blood board donors HLA/HPA gene databases in Kurong, and the scale is still expanding year by year. In the future, the database will gradually realize the comprehensive digital management of comprehensive information from the application, testing, search, results release and database management.

"The platelet gene database items can be implemented on the premise of the selfless dedication of the majority of fixed blood donors." The staff of Wuhan Hemorrhea Center platelet gene database said that the interval between the blood plates of the blood donor is 14 days. If you need to infuse the platelet once in 7 days, multiple genetic blood donors are needed to provide platelets. Therefore, only more blood donors join in and establish a larger -scale platelet gene database to ensure the needs of more patients.

Carry out precise blood transfusion to escort patients' lives

"As we all know, organ transplantation needs to be matched, but many people do not understand, and blood transfusion also needs to be matched." Wuhan blood center platelet gene database staff introduced that blood types include common ABO blood type and rare RH negative blood (that is, "panda blood" To. Input between different blood types may have rejection reactions, which will endanger patient life in severe cases.

In addition to the conventional ABO blood matching, according to the patient's own situation, HLA and HPA may need to be matched. HLA and HPA refers to the surface of platelets on the surface of human white blood cell antigen and platelet antigen. Patients who repeatedly infuse the blood plates, the more opportunities to expose the HLA and HPA antigen with the same type of different types, the more types and quantities that stimulate the body to produce antibodies, which may produce invalid platelet infusion. At this time, it is necessary to further match the HLA and HPA to find the platelets that the patient's body is easy to accept.

For leukemia, regenerative disorder anemia, tumor chemotherapy, etc., platelet reduction or abnormal functional abnormalities, platelet infusion is one of the important treatment methods, so it is of great significance to carry out platelet precision blood transfusion research. From "invalid" to "effective", the accurate blood transfusion of Grandma Li is the vivid practice of the Wuhan Blood Center to carry out the activities of "lower grassroots, inspecting the people, relieving the people's worries, and warming the people." In the future, the blood center will continue to carry out precise blood transfusion research to escort patients' lives. (Reporter Wuye Correspondent Xiao Lijiao Nie Donghang)

[Edit: Yu Lina]

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