"Non -Tiste" should be clear!

For medical professionals for reading reference

Evidence -based medicine, reasonable medication

Number is a 2-tonomozole derivatives. It is a void oxidase inhibitor that reduces the concentration of serum uric acid by inhibiting uric acid synthesis. Compared to Bidol, non -Tiste is a updated uric acid -lowering drug with good uric acid effect. It is widely used in clinical clinical after listing [1].

Today, the small medicine to tell you a few points that you need to pay attention to when using non -Tiss.

Such gout patients need to pay attention!

In a results of cardiovascular research, gout patients suffering from cardiovascular diseases have higher cardiovascular mortality than subbinol treatment.

When deciding to open a non -Tiste, or let the patient continue to take a non -Tiss film, consider the risk and benefits of the non -Tiss's film. Patients with inadequate reactions to the maximum dose of potatol can only be used for patients who are not tolerated to the maximum dose -to -be -proteinol response. Patients who are not recommended for glycoprotein glycol are used. [2]

Not recommended for asymptomatic hyperuricemia

Suitable for long -term treatment of hyperuricemia patients with gout patients. It is not recommended for hyperuricemia that is not clinical.

Some patients with hyperuricemia can occur for a long time, called asymptomatic hyperuricemia. The Guidelines for Hyperthosemia in Europe and the United States is recommended. Asymptomatic hyperuricemia needs to be treated with uric acid reducing drugs only when combined with chronic kidney disease (CKD) and cardiovascular risk factors [3].

At the same time, use non -steroidal anti -inflammatory drugs,

To prevent the acute attack of gout

After starting to take a non -quester film, the gout seizures are often observed. This increase is due to the decrease in serum uric acid levels, which causes uric acid to transfer from tissue deposits. In order to prevent gout when starting the use of non -Tishe films, it is recommended to use non -steroidal anti -inflammatory drugs or autumn pyrosol for preventive treatment.

references:

[1] Zhang Shengzhao, Su Na, Xu Yan, etc., non -Tiste, compared to the cardiovascular adverse incident and death risk of patients with nycurol treatment [J]. Chinese Hospital Pharmaceutical Magazine, 2021,41 (2 ): 7.

[2] Product Information: Febuxostat Tablet, Coated, Alembic Pharmaceuticals Inc., Updated October 12,2021.

[3]Akkineni R,Tapp S,Tosteson AN,et al.Treatment ofasymptomatic hyperuricemia and prevention of vascular disease:a decision analytic approach[J].J Rheumatol,2014,41(4):739⁃748.DOI:10.3899/ jrheum.121231.

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Source: Medical Community

School pair: Zang Hengjia

Responsible editor: Tian Dongliang

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