Kaifuribalin, it is not advisable to "brake"!

For medical professionals for reading reference

Evidence -based medicine, reasonable medication

Probabarin is a γ-aminobutyl acid (GABA) structural analog, which can block voltage dependent calcium channels and reduce the release of neurotransmitters. Clinically, neuromuscular pain, fibromyalgia, and auxiliary therapy are also effective in treating neuromuscular pain, fibromycles, and auxiliary therapy, which are commonly used in the treatment of shingles.

Putibalin's treatment in chronic pain has attracted more and more attention. So what are the problems when using this drug? Let's tell you.

How to stop the medicine correctly?

Like all antiepileptic drugs (AEDs), Putibalin is gradually discontinued to minimize the frequency of epilepsy in patients with epilepsy. After sudden or immediately discontinued Prybalein, some patients had symptoms such as insomnia, nausea, headache, anxiety, sweat, and diarrhea. If Putibalin is discontinued, it should gradually reduce the amount within at least 1 week instead of the sudden stop of the drug.

Be wary of suicide risk!

Patients taking AEDs, including Proven, are taken due to any adaptive disease.

Patients who receive any AED treatment should pay attention to monitoring the appearance or deterioration of depression, suicide ideas or behaviors, and other emotions or behavior abnormalities.

Epilepsy and many other diseases that use AED have increased the risk of suicide ideas and behaviors due to the disease itself and incidence and mortality. If suicide thoughts and behaviors occur during treatment, doctors need to consider whether these symptoms appear on any patient whether they are related to the disease that is being treated.

How to deal with excessive drugs?

In the experience after listing, the most commonly reported adverse events that Pubalin reported in Pedibalin included reduced consciousness, depression/anxiety, mental confusion, excitement, and irritability. He also reported seizures and heart conduction blocks. According to reports, the use of Perbalin overdose or combined with other central nervous system inhibitors may lead to death [1-3].

Puryabarin has no special effect detoxification agent. Puribarin can be removed through hemodialysis. Standard hemodialysis procedures can significantly remove Poribalin (about 50%within 4 hours) [1-3].

references:

[1] Product Information: Pregabalin Capsule, Alembic Pharmaceuticals Inc., Updated September 30 ,2021.

[2] Product Information: Pregabalin Capsule, Pregabalin Solution, Greenstone LLC, Updated Jury 8,2020.

[3] Product Information: Pregabalin Tablet, Film Coated, EXTENDED Release, MSN Laboratories Private Limited, Updated MAY 25,2021..

Do you still want to see what common medicinal methods and points of attention? Welcome to leave a message to tell the small medicine in the world ~

Source: Clinical Pharmacy Channel in the medical community

Author: Wang Xue, Jie Xiaoshi

Review: Director Wang Shiping Pharmacist

Editor: Wang Hang

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