How does brain science help you lose weight

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Author | Diana Kwon

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Student hungry scientists have recently discovered that the fist-shaped cerebelle structure that has not been connected with hunger has previously been considered to have a key area for regulating Prad-Wili's comprehensive significant sense of satiety.

People with rare genetic diseases, Prader-Willi Syndrome, will never feel full. This unsatisfactory hunger will lead to continuous gain and serious obesity.

Scientists who study this issue have recently discovered that the fist -shaped cerebelle structure that has not been connected with hunger before -is a key area for regulating the satiety of such patients.

Via: My Box/Alamy Stock Photo

This discovery is the latest discovery of the study of cerebellar function series. These discoveries reveal that the cerebellum not only participates in sports coordination, but also plays a wide range of role in cognition, emotions and behaviors. "We have created a new field of cerebellar control of food intake," said Albert Chen, a neurologist at the California Institute of California.

The project began with an accidental observation: Chen and his team noticed that they could stop mice to stop eating by activating the small -scale neurons in the cerebellum as the front deep brain nucleus (ADCN) area.

Out of curiosity, researchers contacted the cooperatives of Harvard Medical College. The scientists there recruited 14 volunteers with Pride Wili syndrome and 14 unlimited volunteers, so that they had just finished eating and fasting for at least 4 hours to watch food. At the same time, use functional nuclear magnetic resonance imaging technology to collect their brain activities and compare them.

The analysis of these scanning data shows that Chen's research team seems to be destroyed on the same area ADCN activity found in the same area in Mouse. Among healthy individuals, after fasting, ADCN's response to food images is more active than seeing food images before eating, but this difference is not found among participants with the disease.

VIA: Prad-Willie Syndrome (Tuyuan Internet)

The research results show that ADCN participated in the control of hunger. Researchers from several different institutions on mouse further experiments show that activating the ADCN neurons of animals will make the response to food the happy center of the brain, which significantly reduces food intake. Recently, "Nature" magazine reported in detail this discovery.

Over the years, neurosciences who have studied appetite either focus on the hypothalamus (the area responsible for regulating energy balance in the brain), or pay attention to the reward processing centers such as voltage partition nuclear, but Elanor Hinton, a neurologist at the University of Bristol University in the United Kingdom, said, this, this, this, this, this, this, this, this, this, this, this, this, this, this, this, this, this, this, this, this, this, this, this, this, this, this, this, this, this, this, this, this, this, this, this, this, this, this, this, this, this, this, this, this, this, this, this, this, this, this, this, this, this, should The research team discovered a new eating center in the brain.

Hinton has not participated in the study. He said: "In the past 15 years, I have been studying appetite, but the cerebellum is not my research goal. I think this is a understanding of Praded Willy syndrome and a broader way It is important to solve the problem of obesity of ordinary people. "

Many colleagues in Chen are now planning to test whether they can manipulate this nerve circuit through a non -invasive intervention technology called through the craniacopic stimulation. Chen said that if he succeeds, he hopes to further promote the development of clinical experiments.

Via: Tuyuan Internet

Reference (click slide to view)

1. Diana Kwon, The Cerebellum is your "Little Brain" - -And It Does Some Pretty Big Things, ScientificAmerican.com, January 18, 2019

2. LOW, ALOYSIUS y t et al. "Reverse-Translational Identification of a Cerebellar Satization Network.

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