Tumor and microcyllaria -up and microcyllaria -up natural evolution process in glue female cell tumors

#Tumor#

GBM is the most common intracranial malignant tumor, with a median survival of patients only 14-18 months. More than 90%of GBM patients will recur quickly after receiving treatment. Studies have shown that tumor evolution is one of the main causes of treatment to tolerance and recurrence. Relying on the GBM original/recurrence queue samples, the past studies, the key molecular variation event of the progress of tumor progress in the genome level, provides an important reference for understanding the molecular change mode of GBM under different treatment pressure. At present, the potential molecular mechanism of GBM's evolution before treatment is unclear, especially the role played by the tumor microe environment in the process still needs to be further portrayed. This is mainly due to the lack of suitable research models and technologies to conduct in -depth research on the evolution of cells in its tumor, which has led to no major breakthrough in clinical practice of primary GBM in the nearly ten years.

On September 19, 2022, the International Top Cancer Academic Journal Cancer Discovery published a cooperation paper for the Wang Qianghu team of Nanjing Medical University, Jiang Tao Team of the Beijing Institute of neurosurgery, and the You Yongping team of You Yongping, the First Affiliated Hospital of Nanjing Medical University. "Natural Coevolution of Tumor and Immunoenvalonment in GlioBlastoma". For the first time, the research team used a multi -lesion model to reveal the process of collaborative natural evolution in tumor and micro -ring in Glioblastoma (GBM).

The team of Professor Wang Qianghu, Professor Jiang Tao, and Professor You Yongping closely collaborated to collect the samples of patients with precious polysiler gel tumors, and conducted sequencing of single -cell transcription groups and general exterior sub -sequencing. Studies have found that multiple stoves of the same patient originated from the same ancestor and evolved alone in space. Based on these samples, the team has developed a computing method to characterize the characteristics of GBM's natural evolution -NATURAL EVILUTION SIGNATURE (NES), and verify that the method can effectively predict the prognosis of patients with GBM. In addition, the research team discovered that hypoxia in tumor tissue was one of the important starting factors that caused rapid tumor evolution. The activation of HIF1A transcription factors inside the hypoxia -induced tumor can further drive downstream FOSL2 activation and increase ANXA1 expression, and then recruit and domesticate peripheral blood source macrophages, which eventually forms an immunosuppressive microcirculation. These domesticated macrophages can further promote tumor evolution and improve tumor invasion capabilities by secreting CCL2 such as CCL2.

This study provides a new idea for comprehensively understanding the natural evolution process and molecular mechanism of micro -environment coordinated tumors. It also provides new targets and methods for inhibiting tumor progress and improving the effects of GBM immunotherapy.

Original link:

https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.cd-22-0196/709256/natural--tumor-nmmunoenvironoment

Want to know more exciting content, come and pay attention to BIOART biological art

- END -