Shantou Health Lecture Hall: No longer "liver", artificial liver saves your "careful liver"

The liver is the "chemical factory" of the human body. It assumes a variety of functions such as detoxification and metabolism. Once the liver falls down due to excessive fatigue -liver failure, human life will end with it. Artificial liver is an important technical method to solve this problem. Artificial liver is an in vitro -support system based on hematological purification technology. When the human liver problems occur, metabolic waste or toxins accumulate in the body, artificial liver can come in handy to replace liver detoxification and metabolic functions.

Recently, the Department of Critical Medicine of the Initiative Hospital of Shantou University School of Medicine carried out artificial liver technology, which successfully reduced yellow to a patient with hyperbilotin ledin, and created favorable conditions for the patient's subsequent anti -tumor treatment.

Auntie Xie, female, confirmed pancreatic cancer, has a variety of treatment methods for surgery, chemotherapy, and immunotherapy. The encephalopathy "", then transferred to the Department of intensive medical department for treatment. After fully communicating with Auntie Xie's family members and obtaining the consent of the family members, the medical team decided to treat an artificial liver treatment for Auntie Xie, strive to improve the patient's hepatic encephalopathy symptoms, and win the opportunity for subsequent anti -tumor treatment.

The artificial liver mode selected this time is the dual plasma adsorption system (DPMAS). After careful treatment by the medical team, after three artificial liver treatment, the patient's blood total blood redness drops from 760umol/L to 320umol/L. Significant improvement of mental symptoms, no side effects such as coagulation dysfunction during treatment, and then transferred to hospital hepatobiliary surgery for follow -up treatment.

1. What is artificial liver?

Artificial liver technology, also known as artificial liver support system, is an effective liver function replacement therapy.治疗原理就是将病人的血液通过体外装置清除机体各种有害物质并补充需肝脏合成或代谢的蛋白质等必需物质后再输回病人体内，改善水、电解质、酸碱平衡等内环境，暂时辅助或Part of the function of the liver and create a good internal environment for liver cell regeneration. Common treatment modes include plasma replacement, dual -plasma molecular adsorption system, blood irrigation, plasma dialysis filtration, etc.

The dual plasma molecular adsorption system (DPMAS mode) mentioned above, which is a new type of combined artificial liver treatment mode, combines the advantages of plasma irrigation and bilirubin adsorption technology, and exchanges the separated plasma in sequence to exchange resin in order And neutral large -hole adsorption resin can adsorb, which can not only adsorb bilirubin, but also remove various toxins and inflammatory medias, does not consume plasma, can alleviate the problem of plasma resources, but also make up for specific bilirubin adsorption Insufficient, quickly improve patients' jaundice symptoms, prevent the vicious circle of liver damage, especially suitable for patients with total bilirubin levels of blood redness> 500umol/L. Specifications are both centered and improved the success rate of treatment.

2. What are the treatment scope of artificial liver?

1. Those with acute, subacute and chronic liver failure caused by various reasons (virus, alcohol, drugs, poisoning, etc.);

2. Severe cholenecanic accumulation liver disease, poor drug treatment;

3. Various causes cause patients with hyperbilotin ledin (such as medicinal, autoimmune, and hyperbilotinmia after surgery);

4. Patients with complications of liver failure (such as hepatic encephalopathy, liver and kidney syndrome, hydrolysis disorders, and systemic inflammation reactions);

5. Patients with liver transplantation perimeter (such as advanced liver failure and liver transplantation waiting for suppliers, rejection after liver transplantation, and no functional period for transplantation liver).

3. What are the contraindications of artificial liver?

1. Activating digestive tract bleeding, DIC and other significant bleeding tendencies, such as reduced thrombocytopenia (platelets <50*10^9/L) and the original activity of coordinase is extremely reduced (≤20%);

2. Severe systemic infection, unstable blood circulation system, severe cardiovascular disease, cerebrovascular disease, middle and advanced pregnancy;

3. The shock caused by various reasons is not corrected, and other reasons cannot cooperate with the treatment.

4. Is artificial liver suitable for patients with malignant tumors?

With the development of treatment technology, the treatment of anti -tumor treatment is diversified, and the survival time of patients with malignant tumors has been extended. Among them, chemotherapy is an important weapon for killing tumor cells. Many patients often give up because of severe liver injury caused by chemotherapy. With the escort of artificial liver technology, it can greatly improve the tolerance of chemotherapy and improve the quality of survival of patients. Essence In addition, malignant tumor compression/infringement of the biliary system has severe internal environmental disorders or other complications, which makes patients unable to withstand endoscopic treatment. Through the implementation of artificial liver technology, it can create favorable conditions for patients with endoscopic reduction in endoscopy.

(Cai Chunhua Shantou University School of Medicine College of Medicine Hospital, the Department of Severe Medicine, Department of Severe Medicine)

Source | Yangcheng Evening News · Yangcheng School

Responsible | Chen Yueyue

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