Why do hospitalization increase the risk of dementia?

Text ｜ Xu Rui

Receiving infection treatment in the hospital may be related to the risk of Alzheimer's disease. Image source: Canadian Press/Shutterstock

On September 15, a new study published by the Public Science Library -Medicine pointed out that those who were treated in the hospital for infection may be higher in the risk of early hairstyle Alzheimer's disease a few years later.

Bacterial infections, especially urinary and reproductive organs, are closely related to the high risk of Alzheimer's disease.

In addition, the infection of virus infections, especially the gastrointestinal tract and central nervous system is also related to the high risk of Alzheimer's disease.

Many previous studies have hinted that there is a potential connection between Alzheimer's disease and specific pathogenesis (such as herpes virus).

Sun Jiangwei (Yin) of the Karolinska Medical College of Sweden analyzed about 290,000 patients with Alzheimer's disease and 1.4 million ages and gender -matching unheated Altzheimer's disease in Sweden. Healthy.

They found that 17.4%of patients were diagnosed with Alzheimer's disease before the age of 60, 17.4%of them were treated in the hospital for at least 5 years infected. In contrast, among those who have not been diagnosed with Alzheimer's disease at the same age, the proportion of treatment in the hospital for infection within 5 years was 9.8%of the treatment in the hospital.

"Although there are a lot of clinical data in this field ... but there are not many related observation research. Therefore, the results of the above research should be considered an important supplement," said Antonios Douros at McGill University in Canada.

However, the results of the above research do not necessarily show that infection will increase the risk of Alzheimer's disease. Another possibility is that the early unlimited physical changes caused by Alzheimer's disease may make people more vulnerable to infection.

Pyry Sipila, the University of Helsinki, Finland, pointed out that such factors such as immune dysfunction, alcoholism, and drug abuse may also increase the risk of Alzheimer's disease and infection.

"In order to convert this work into clinical practice, we need to study to reduce whether infection can reduce the risk of patients with Alzheimer's disease," said Rutendo Muzambi, a London Health and Tropical Medical College.

Related thesis information:

https://doi.org/10.1371/journal.pmed.1004092

"China Science News" (2022-09-20 No. 2 Edition International)

Edit | Zhao Lu

Capture | Zhihai

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