This scientific research project has won valuable treatment opportunities for stroke patients

Author:Guangxi Satellite TV Time:2022.09.09

Human brain, day and night constantly managing all the physiological functions of our thinking, emotion, physical feelings and exercise, regulating body temperature, heartbeat, breathing, etc., like a "headquarters", analyze the information collected everywhere, and Make a decision and order. The unblocked cerebral blood vessels are the basis of the normal work of the human brain. Once the cerebrovascular problems occur, it will cause irreversible damage to the brain cells, cause the corresponding function of the brain, and even lose their lives. We call it "stroke", and the medical name is called "stroke."

Stroke has the characteristics of high incidence, high residual rate, high mortality, high recurrence rate, and high economic burden. Focusing on the treatment time window, treatment methods, and rehabilitation of the stroke, the Rongjiang National Medical College hosted the research on the project of "New Strategy Construction and Clinical Application of Stroke and Stroke". The advantage of time management, at the same time, pays attention to the treatment of depression complications after stroke, and won valuable treatment opportunities for patients with stroke. This scientific research project was awarded the first prize of the 2021 Guangxi Science and Technology Progress Award.

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Stroke is a kind of acute cerebral vascular disease. Once the ischemic stroke occurs, every 1 minute of thrombolytic dissolved dysplasia dies, which means that over time, patients with strokes are quickly losing their loss. Brain function and physical function. The number of new cases of stroke every year in my country is about 2.4 million, as many as 1.1 million patients who die in strokes, 60%-70%of the surviving patients have different degrees of disability, which seriously affects the quality of survival of patients and gives family and society. Caused a heavy burden is an important reason for the poverty and returning to poverty due to illness in rural areas in my country.

Within the first four and a half hours of the onset of ischemic stroke patients, it is the key window time for the living quality of patients with patients. If it can be treated in time window in time, the patient may not only get effective survival guarantees, but also also obtain effective survival guarantees, and it may also be effective. It may effectively reduce or reduce the occurrence of disability. However, there are many medical treatment sections involved in this. Professor Li Xuebin and team members of the Youjiang National Medical College of National Medical College of National Medical College of National Medical College have carried out a large number of research on the level of prevention and control of strokes and improved prevention and control of prevention and control. Between the Department of Internal Medicine, a green life channel was created.

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Starting from the first time to receive patients with stroke, the professional stroke group involved in taking over, and immediately entered the standard operating procedures for thrombolysis on patients.

After the thrombolysis, the patient was transferred to the intensive care unit of the neurology department for further observation. Through the optimization process and mobilizing the cooperation of the relevant departments of the stroke center, the time from admission to injection of thrombolytic drugs takes more than 1 hour to shorten to the current 30 minutes to complete, and the standardized operating procedures are formed, which is conducive to at all levels. Regular operations of medical institutions.

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In order to shorten the time of admission to the admission, the close cooperation of multi -disciplines such as emergency department, neurology, neurosurgery, radiology, intervention room, and inspection department need Only to determine whether you can take the embolism and open the cerebral blood vessels. not

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If the thrombolysis is unsuccessful, the patient will be sent to the intervention chamber for cerebral blood vessels, and then the intravascular intervention is given to different situations.

Starting from basic research, the research team of Youjiang National Medical College carried out a transformation of medical research and clinical research, and achieved a series of research results, including the establishment of an acute ischemic stroke venous thrombolytic standard operation procedure, reasonable drug guidance specifications for stroke, heart source Sexual stroke screening and other stroke prevention and control strategies, carry out and improve hemorrhagic stroke minimally invasive surgery, intravascular intervention therapy technology, rehabilitation prevention and control programs, and strengthen training to improve the level of prevention and control technology. As the main editor, the team wrote 2 corresponding industry application standards and 5 items, which promoted the standardized diagnosis and treatment of strokes in my country. At the same time, through the basic research of stroke, the scientific research team found that: the polymorphic polymorphism of the sub -hydrogen folic acid reducing enzymes is significantly related to the west of the Zhuangzhuang arechemia. Potential biomarkers; Hisbonic drugs can play a neurological function by regulating autophaization activity, reducing inflammatory response, improving the integrity of blood and brain barrier; Sanqi total saponin to regulate the genetic network and participate in post -stroke nerve protection.

In fact, as one of the authentic medicinal materials in Guangxi, Sanqi has a long history of stroke treatment. Researchers have carried out a lot of research on the three national natural science fund projects related to Sanqi, further verification and explanation of Sanqi treatment Mechanism, this study, provides theoretical basis for precision prevention and control of stroke from the perspective of genetic molecular levels and combination of traditional Chinese and western medicine.

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We found that Sanqi has a variety of active ingredients to protect the ischemic damage cells. At the same time, it is found that the 817 differences of expression genes are related to the treatment effect of the Sanqi pair of stroke recovery. These genes participated in after multiple signal channels to participate in the neuronal blood vessels after ischemia. The protection of the unit, 9 of which were first reported to be related to the neural protection effect of Sanqi.

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For stroke patients, in addition to the dangerous condition, there is also a great probability of depression after stroke, which is a condition that is easily overlooked in Chinese stroke treatment.

Depression after stroke is an unknown neuropathy complications that occur after stroke. The manifestations mainly include the patient's emotional depression, sleep disorders, and changes in personality. There will be a tendency to commit suicide.

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After the stroke, depression was prone to the occurrence of a few weeks to a few months after the stroke. Among them, the incidence of depression after the first cerebral infarction patients suffered from 33.97%, and the incidence rate reached 58.6%within 3 months after stroke. Because patients with stroke are restricted by physical and cognitive dysfunction, they are often unable to express their dysfunction, and depression after stroke is often misdiagnosed. It will have a serious impact on the recovery after stroke, which will not only extend the hospitalization time, but also reduce the effect of neurhabitation and quality of life.

According to the research of the Youjiang National Medical College, in the post -stroke depression disease mechanism, the risk of increasing the genotypes of the genes of part of the genes of the lipoprotein E of the Ledin E; The interaction of human white blood cell antigen A gene, through immune media media and cell adhesion, plays a role in the development of cerebral hemorrhage and depression; the volume and the number of lesions of patients may be Independent risk factors; changes in brain network topology may also participate in the onset of depression after stroke. Clinical studies have confirmed that resveratrol's treatment of depression after stroke is effective, promoting neurological recovery of patients with depression after stroke, and improving the ability of daily life. The anti -depression mechanism may be to reduce the level of patients' inflammatory cytokines and improve monoamine neurotransmitting levels.

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Based on the clinical study of antidepressant effects on resveratrol to play a role in antidepressant, a new strategy of combining Chinese and Western combination in the prevention and treatment of stroke depression, that is, the antidepressant efficacy and tolerance of the antidepressant and tolerance are improved by the combination of Chinese and Western combination. At the same time, combined with acupuncture electro -acupuncture treatment, the side effects of antidepressant western medicine are reduced.

Through strengthening training and mission, a series of achievements in the project have been promoted and applied in more than 100 hospitals across the country. More than 8,000 medical staff of depression prevention and control after training stroke and stroke have benefited more than 300,000 patients, which greatly improved the relevant prevention and control technology. The level of quality has reduced the mortality and disability rate of patients with stroke, reduced complications, shortened the hospitalization time, improved the quality of survival of patients and reduced social and family economic burdens.

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The research results can receive the first prize of the Guangxi Science and Technology Progress Award. It is the correct guidance of the competent authority, the strong support of the school and affiliated hospitals, and the joint efforts of all team members. We must take this award as a new starting point and spur in the future, and further in -depth research in the basis and clinical clinical stroke to achieve more results!