Guangdong experts: patients with such nasopharyngeal cancer, the efficacy of simply radiotherapy and "reducing drug reduction"

Radiotherapy, chemotherapy, chemotherapy, or combined targeted therapy? In clinical treatment, of course, doctors want to use a treatment method to resist nasopharyngeal carcinoma well to reduce the "superimposed" toxic and side effects of multiple treatments.

Recently, a new achievement of the Cancer Prevention and Treatment Center of Sun Yat -sen University has attracted much attention. The study of the team of Ma Jun and Sun Ying, the team of the college, showed that there are many domestic medical institutions in China that patients with low -risk nasopharyngeal cancer do not need to chemotherapy, and individual radiotherapy has the same effect. Patients can avoid the toxic effects brought by chemotherapy and improve the quality of life. The results have been published online on the top international medical journal "American Medical Association".

01.

Find "drug reduction" treatment strategy for patients

According to the guidelines for the clinical practice of malignant tumors released by the national comprehensive cancer network, the treatment of patients with early nasopharyngeal cancer is mainly based on simple radiotherapy, and patients with chemotherapy or chemotherapy or auxiliary chemotherapy in the same period in the same period.

However, for patients with mid -term nasopharyngeal carcinoma, the recommended evidence of the treatment of chemotherapy during the same period comes from clinical trial data of the two -dimensional regular radiotherapy period.

Professor Sun Ying of Sun Yat -sen University Tumor Prevention and Control Center introduced that the development of radiotherapy technology has gone through three stages. In the 1950s, radiotherapy was determined according to the body table logo, and the treatment effect was limited; in the 1980s, the two -dimensional regular radiotherapy technology began to appear, and the use of X -ray positioning but not high. Since 2000, strong radiation therapy technology Gradually developing radiotherapy is more accurate.

In recent years, the treatment of strengthening radiation has significantly improved the curative effect. Patients (phase II and T3N0) patients in the medium -term nasopharyngeal carcinoma (phase II and T3N0) have no tumor survival rate, total survival rate, no distant metastasis survival rate, and non -recurring growth rate. more than 90 percent.

Under the premise of continuous improvement of radiotherapy technology in these years, do patients with nasopharyngeal cancer need to receive chemotherapy at the same time? Does chemotherapy at different periods have the same effect? Can patients reduce the pain of chemotherapy? Experts began to find answers.

02.

The efficacy of simple radiotherapy does not drop and "reduce poisoning"

Therefore, the team of Professor Ma Jun and Sun Ying took the lead to cooperate with 4 units including Foshan First People's Hospital, Wuzhou Red Cross Hospital, Fifth Hospital of Sun Yat -sen University, and Xiehe Hospital of Tongji Medical College of Huazhong University of Science and Technology. Large -scale forward -looking, multi -center, random control, non -inferior phase 3 clinical trials, in the same period of low -dangerous nasopharyngeal carcinoma patients with radiotherapy VS, to find comparison results.

The results of the study showed that among patients with low nasopharyngeal cancer, the simple radiotherapy group was similar to the survival results of each existing chemotherapy group at the same time. Among them, the three -year tumor -free survival rate of the simple radiotherapy group was 90.5%, and the radiotherapy group was 91.9%in the same period, and the results of the two groups were similar. The total survival rate of 3 years, no recurrence survival rate, and no distant transfer survival rates are similar between the two groups.

However, in terms of toxic and side reactions and quality of life, the results show that the incidence of severe toxic and side reactions in the simple radiotherapy group (17%) is significantly reduced compared with the martial chemotherapy group (46%) in the same period, including the decline in white blood cells, the decline in neutral granulocytes, nausea, and nausea, and the nausea, and the nausea, and the nausea, and the nausea. Vomiting, decreased appetite, decreased weight, mucositis. In addition, the quality of life of patients with a simple radiotherapy group is significantly better than the firing group at the same time.

"Studies have found that for patients with low -dangerous nasopharyngeal carcinoma, simple radiotherapy can achieve the treatment effect of patients without decreased treatment effects, and significantly reduces toxic and side reactions such as severe gastrointestinal reactions, bone marrow suppression, and decreased weight in treatment. At the same time The advanced toxicity such as thyroid dysfunction is also greatly reduced. "Professor Sun Ying introduced.

Professor Ma Jun believes that strong radilation therapy is now widely used in domestic radiology departments, and the results of the research are very vivid.

Ethan Bach, the director of the University of North Carolina University and the deputy editor -in -chief of the American Medical Association, published a video of the video. It is believed that the research results are not only suitable for patients in the high incidence of nasopharynx carcinoma, but also for low -hair cancer areas such as Europe and the United States. The guide is adopted to change clinical practice. The study will benefit 20%of patients with nasopharyngeal cancer, while improving the quality of life at the same time without reducing efficacy.

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Edit | Chen Le Ren Junfei Responsible | Zhang Xiuli

Source | Wen Chaoyang Chen Yan Zheng Minshan

Produced by Guangdong Health Online All -Media Team

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